Serum Cholesterol Reduction and Cholesterol Absorption Inhibition in CaCo-2 Cells by a Soyprotein Peptic Hydrolyzate

Potato and Soy Peptide Diets Modulate Lipid Metabolism in Rats

“…28) Furthermore, it has been reported that the bile acid-binding capacity of the high-molecular-weight fraction from soybean protein was higher than that from other vegetable proteins. 29) However, the data for bile acid excretion are not supported by the data for the CYP7A1 mRNA level in this experiment.…”

Effects of Dietary Oyster Extract on Lipid Metabolism, Blood Pressure, and Blood Glucose in SD Rats, Hypertensive Rats, and Diabetic Rats

“…This means that oyster extract prepared in the present experiment is structurally and functionally different from the hydrolyzate produced from oyster protein during gastrointestinal digestion. Nagaoka et al 42) indicated that the soyprotein peptic hydrolyzate exerted hypocholesterolmic action through inhibiting cholesterol absorption by direct interaction between cholesterol in mixed bile salt micelles and peptide or protein. Hydrolyzate from oyster protein produced in the gastrointestinal tract might have a higher capacity to bind to cholesterol in mixed bile salt micelles as compared with the oyster extract prepared in the present study, inducing an enhancement of neutral steroid excretion into the feces.…”

A Cattle Heart Protein Hydrolysate Ameliorates Hypercholesterolemia Accompanied by Suppression of the Cholesterol Absorption in Rats and Caco-2 Cells

“…Caco-2 cells were acquired from the American Type Culture Collection and maintained as previously described. 17,18) Monolayers were grown in 48-well plastic dishes containing 0.5 ml of fetal bovine serum supplemented with DMEM. The […”