Serum cholinesterase loci E1 and E2 polymorphisms among Egyptians

We estimated the frequencies of serum butyrylcholinesterase (BChE) alleles in three tribes of Mapuche Indians from southern Chile, using enzymatic methods, and we estimated the frequency of allele BCHE*K in one tribe using primer reduced restriction analysis (PCR-PIRA). The three tribes have different degrees of European admixture, which is reflected in the observed frequencies of the atypical allele BCHE*A: 1.11% in Huilliches, 0.89% in Cuncos, and 0% in Pehuenches. This result is evidence in favor of the hypothesis that BCHE*A is absent in native Amerindians. The frequencies of BCHE*F were higher than in most reported studies (3.89%, 5.78%, and 4.41%, respectively). These results are probably due to an overestimation of the frequency of allele BCHE*F, since none of the 20 BCHE UF individuals (by the enzymatic test) individuals analyzed showed either of the two DNA base substitutions associated with this allele. Although enzymatic methods rarely detect the presence of allele BCHE*K, PCR-PIRA found the allele in an appreciable frequency (5.76%), although lower than that found in other ethnic groups. Since observed frequencies of unusual alleles correspond to estimated percentages of European admixture, it is likely that none of these unusual alleles were present in Mapuche Indians before the arrival of Europeans.

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Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians

Acuña

Eaton

Ramírez

et al. 2003

American J Phys Anthropol

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Serum cholinesterase polymorphism in France: an epidemiological survey of the deficient alleles detected by an automated micro-method

Arnaud

Brun

Llobera

et al. 1991

Annals of Human Biology

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The polymorphism of the serum cholinesterase CHE 1 was determined using an automated micro-method. The procedure developed represents an improvement of the manual method and enabled us to study more than 2400 samples obtained in 15 different geographical areas in France. Four alleles were detected: CHE1* U, A, S and F. An exceptionally high frequency of an atypical variant (CHE1*A) was observed in the central part of France (Cevennes, Limousin and Dauphiné). The populations belonging to these areas are at particular risk in case of anaesthesia.

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Serum cholinesterase loci E1 and E2 polymorphisms among Egyptians

Cited by 2 publications

References 17 publications

Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians

Genetic variants of serum butyrylcholinesterase in Chilean Mapuche Indians

Serum cholinesterase polymorphism in France: an epidemiological survey of the deficient alleles detected by an automated micro-method

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