Serum Cobalamin Concentration in Sickle Cell Disease (HbSS)

Osifo, Bola O.A.; Lukanmbi, F.A.; Adeyokunnu, A A

doi:10.1159/000206605

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…In Sudanese children with SCA age 6 months-15 years Vitamin B12 level was found to be significantly lower than the control and 7.1% were found to be deficient [123]. Similar results were reported by other studies [124][125][126][127]. 15% of children with sickle cell anemia had low serum folate despite adequate supplementation [127].…”

Section: Nocturnal Enuresis and Vitaminssupporting

confidence: 84%

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Ahmed¹

2017

Med Surg Urol

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Children with sickle cell anemia (SCA) have a tendency to have nocturnal enuresis (NE) more than normal children with males being more affected than females. Mechanisms of NE that operate in normal children probably do so in children with SCA. Postulated causes of nocturnal enuresis in individuals with SCA include hyposthenuria causing nocturnal polyuria, reduced bladder capacity or nocturnal bladder overactivity, sleep disordered breathing and an increased arousal thresholds. The variation in the reported prevalence rate of NE in SCA is probably due to differences in definition criteria and methodology. This review will discuss the prevalence rate and postulated causes of NE in children with SCA.

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Section: Nocturnal Enuresis and Vitaminssupporting

confidence: 84%

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Ahmed¹

2017

Med Surg Urol

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“…An other metabolic requirement for cobalamin in sickle cell disease is in the area of immune response. This was evident in a previous study [21] where we ob served strong negative correlations between cobal amin and white blood cell count and cobalamin and neutrophil differential. The results in this study reveal that marked changes occur in the pattern of these binding proteins with age among sickle cell patients as it occurs among healthy populations, though the changes are not identical.…”

Section: Cobalamin (Bi2)supporting

confidence: 79%

“…Low erythrocyte folate concentra tions were observed in sickle cell children with rela tively low serum cobalamin though they were receiv ing a daily dose of folate supplementation [21]. An other metabolic requirement for cobalamin in sickle cell disease is in the area of immune response.…”

Section: Cobalamin (Bi2)mentioning

confidence: 99%

Serum Unsaturated Vitamin B<sub>12</sub> Proteins in Adult Patients with Sickle Cell Anaemia (Hb SS)

et al. 1989

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The unsaturated vitamin B12 binding capacity (UBBC) of serum, the three transcobalamins (TC I, TC II, TC III) and serum cobalamin have been studied in adult sickle cell patients with Hb SS. An increase in the level of the binding capacities of TC I and TC III resulting in an increase in UBBC was observed in these patients. There was no difference in the level of the binding capacity of TC II, while there was a significant reduction in the level of serum cobalamin. These changes in the pattern of these binding proteins are discussed in relation to the changes of these binding proteins in paediatric sickle cell patients with Hb SS. The results indicate that the pattern of these binding proteins changes with age among sickle cell patients resulting in an increased level of the binding capacities of TC I and TC III. These increases lend support to the view that these two similar binding proteins are involved in the defence mechanism of the body.

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“…Low serum cobalamin (B12) and an increase in unsaturated cobalamin binding capacity have been reported in sickle cell patients [73,74]. The low serum cobalamin could be related to an impairment of folate polyglutamate synthesis in BI2 deficient red cells [74].…”

Section: Micronutrients Water Soluble Vitaminsmentioning

confidence: 99%

“…The low serum cobalamin could be related to an impairment of folate polyglutamate synthesis in BI2 deficient red cells [74]. Reduced levels of vitamin C [46] and riboflavin [45] have also been documented.…”

Section: Micronutrients Water Soluble Vitaminsmentioning

confidence: 99%

Nutrition and sickle cell disease

1987

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The role of protein and calorie deficiency in sickle cell disease remains poorly defined. While such features as growth retardation, impaired immune function, and delayed menarche do suggest a relationship between sickle cell disease and undernutrition, measurement of more direct nutritional parameters in these patients have yielded mixed results. Anthropometric measurements such as skinfold thickness are subnormal in many but not all reports. Serum protein levels are normal, but low values for serum lipids have been reported. Finally, one small study shows an improvement in both growth parameters and clinical course following caloric supplementation. A variety of micronutrient deficiencies have been suggested in sickle cell disease. Numerous case reports describing an exacerbation of the chronic anemia that was reversed by folic acid therapy led to routine folate supplementation. More recent studies have shown, however, that clinically significant folic acid deficiency occurs only in a small minority of sickle cell patients. Clearly, more work is necessary to define the cost/benefit ratio of routine folic acid supplementation. Pharmacological amounts of vitamin B6 and certain of its derivatives possess in vitro antisickling activities. Nevertheless, a small clinical trial failed to demonstrate any consistent hematologic effects of B6 supplementation. Several reports indicate that vitamin E levels are low in sickle erythrocytes. Since these abnormal red cells both generate excessive oxidation products and are more sensitive to oxidant stress, and because oxidants appear to play a role in ISC formation, vitamin E deficiency could well be linked to ISC formation and hemolysis. Small clinical trials, however, have again failed to produce a clear hematological response in sickle cell anemia. The role of zinc in sickle cell disease has received considerable attention. Though studies are generally small, most do support a relationship between sickle cell disease and zinc deficiency. Etiologic associations between zinc deficiency and such complications of sickle cell disease as poor ulcer healing, growth retardation, delays in sexual development, immune deficiencies, and high ISC counts have all been suggested. Most of these studies need further corroboration. Iron deficiency is now known to be a relatively common occurrence in sickle cell anemia, especially in children and pregnant women. The theoretical benefits of concomitant iron deficiency and sickle cell anemia remain to be proven in a controlled clinical trial.(ABSTRACT TRUNCATED AT 400 WORDS)

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Serum Cobalamin Concentration in Sickle Cell Disease (HbSS)

Cited by 8 publications

References 8 publications

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Serum Unsaturated Vitamin B<sub>12</sub> Proteins in Adult Patients with Sickle Cell Anaemia (Hb SS)

Nutrition and sickle cell disease

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