Serum Concentration–Dose Relationship and Modulation Factors in Children and Adolescents Treated with Fluvoxamine
Regina Taurines,
Gesa Kunkel,
Stefanie Fekete
et al.
Abstract:Introduction: Fluvoxamine is used in children and adolescents (‘youths’) for treating obsessive compulsive disorder (OCD) but also off-label for depressive and anxiety disorders. This study aimed to investigate the relationship between fluvoxamine dose and serum concentrations, independent correlates of fluvoxamine concentrations, and a preliminary therapeutic reference range (TRR) for youths with OCD and treatment response. Methods: Multicenter naturalistic data of a therapeutic drug monitoring service, as we… Show more
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