Serum Cortisol and BMI in Chronic Diseases and Increased Early Cardiovascular Diseases

Abstract

The purpose of this study was to examine the role of cortisol, and it is related to BMI in the chronic diseases which may increase early cardiovascular disease (CVD) in old Iraqi. The subjects were 116 adults, aged 51-71 years. Body Mass Index (BMI), Waist Circumferences (WC) and Waist Hip Ratio (WHR) were used as a measure of adiposity. Investigation showed highly significant difference between patients in BMI ranges, most of male were in an obese weight range (48.5%), as well in women. There were no significant correlations between serum cortisol concentration and age both gender groups. While there were highly significant correlations between cortisol level and BMI, waist, and WHR (except in female subjects), also there were highly significant correlations between cortisol level and SBP,DBP (mmHg)only in male. In both groups, total cholesterol concentration, FBS, and A1C were significantly correlated with serum cortisol. Negatively correlated has been observed between serum cortisol and HDL-C in men but not in women. In men, the results of cortisol with CV risk factors (dyslipidemia, D.M, hypertension, at least 2 risk factors and three risk factors) show significant differences (p>0.0). In summary, there is a major association between cortisol levels, obese, and chronic diseases. These conclusions promote the hypothesis that the opposing effect of adiposity on the chronic diseases might be mediated by cortisol. This association could cause early development of cardiovascular diseases even in males.

An Assessment of Glutathione-S-Transferase and Lipid Profile in Obese Iraqi Patients

“…Another study [27] showed a highly significant BMI with obesity. According to the GST results, there is a substantial difference in GST between these groups and obesity; these findings are consistent with earlier studies [28].…”

Levels of Serum Lipid profile and Kidney Function Tests in Iraqi Hypertensive Patients: Duration Effect Study

“…High levels of serum cholesterol are recognized as a major risk for coronary heart disease and stroke [6]. About 80% of hypertensive patients have co morbidities such as fatty, glucose intolerance and abnormalities in lipid metabolism [4].The results of elevated total cholesterol in hypertensive patients agree with Adedji et al [15] and Goran et al [16]. There is a significant correlation between total cholesterol and systolic blood pressure, also between TG and diastolic blood pressure [17].In the present study, the higher plasma TC, TG and LDL levels in the patients than in the control group agrees with earlier studies [18].…”

“…It is the main risk factor for cardiovascular disease, congestive cardiac failure, stroke and end-stage of kidney disease [3]. Hypertension is one of manifestation of metabolic syndrome [4]. High blood pressure and dyslipidemia are main risk factors for coronary heart disease and account for more than 80% of death disability in low and middle -income countries [5].…”

Assessment of Atrial Natriuretic Peptide (ANP) and Lipid Profile for Hypertension Patients in Thi-Qar province, Iraq

“…It is the main risk factor for cardiovascular disease, congestive cardiac failure, stroke and endstage of kidney disease (Casey et al, 2006). Hypertension is one of manifestation of metabolic syndrome (Hassan et al, 2016).…”