Serum creatine kinase BB as predictor of periventricular haemorrhage in preterm infants

Bor, Margot van de; Janssen, J.W.; Bel, Frank van; Ruys, J.H.

doi:10.1016/0378-3782(88)90005-9

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…[356710111213141516171819202122] Figures 1 and 2 depict the percentage of IVH cases in each report that occurred during these 4 time intervals in LBW and VLBW, respectively. These plots show that timing of IVH is bimodal in both LBW and VLBW neonates.…”

Section: Timing Of Ivh Occurrencementioning

confidence: 99%

“…[45678] A large body of evidence has shown that a considerable number of IVH cases occur during the first hours of life (HOL). [35679101112131415161718192021222324] Reports in the literature from the 1980s and 1990s established that IVH occurring within the first HOL and later-occurring IVH must be analyzed separately as their antecedents may be different. [252627] However, a more recent large and growing body of literature has considered early and late IVH as a single entity and has neglected the fact that a significant number of IVH cases may have occurred prior to the investigator's study intervention or antecedents of IVH.…”

Section: Introductionmentioning

confidence: 99%

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A systematic review and meta-analysis of the timing of early intraventricular hemorrhage in preterm neonates: Clinical and research implications

Al-Abdi

Al-Aamri

2014

J Clin Neonatol

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A considerable number of intraventricular hemorrhages (IVH) occur within the first hours of life (HOL). Temporality between IVH and its antecedents as well as a consistent definition of “early IVH” is lacking in a large and growing body of literature. We performed a systematic review of prospective studies that reported onset of IVH in preterm neonates within the first HOL and afterwards. The English literature was searched using three databases up to March 2013. Four timing periods of IVH can be compared in 16 identified studies: 0-6; 7-12; 13-24; after 24 HOL. The 0-6 and after 24 HOL were the major modes of IVH timing. Pooled IVH proportions were estimated through a meta-analysis of studies that were conducted after antenatal steroid and surfactant era. In neonates weighing ≤1500 g at birth: 48% of IVH (95% CI: 42-58%, 5 studies, 279 IVH cases) occurred during 0-6 HOL and 38% (95% CI: 19-57%, 4 studies, 241 IVH cases) after 24 HOL. The 0-6 HOL is the shortest, most vulnerable period for IVH, thus, an early IVH is an IVH occurs in it. Such early IVH had prognostic, etiological/preventive and medicolegal implications. Accordingly, preterm neonates at risk of IVH should have their first routine screening head ultrasound at about 6 HOL. Future research exploring the antecedents of IVH should guaranty the temporality between these antecedents and IVH. Additional research will be required to determine whether the long term neurological outcomes of early and late IVH are the same.

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Section: Timing Of Ivh Occurrencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis of the timing of early intraventricular hemorrhage in preterm neonates: Clinical and research implications

Al-Abdi

Al-Aamri

2014

J Clin Neonatol

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Pathophysiology of Intraventricular Hemorrhage in the Neonate

Inder¹,

Volpe²

2004

Fetal and Neonatal Physiology

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Serum Ck‐bb Activity in the Preterm Infant and Outcome at Two and Four Years of Age

Ouden¹,

Bor²,

Bel³

et al. 1990

Develop Med Child Neuro

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SUMMARY The relationship between serum creatine kinase brain‐specific isoenzyme (CK‐BB) activity immediately after birth and neurodevelopmental outcome at two and four years corrected age was studied prospectively in 45 preterm infants (< 34 weeks gestation). Nine infants died during the neonatal period and one was lost to follow‐up. Of the 35 children available for follow‐up, seven had motor disabilities: four severe diplegia, two mild to moderate diplegia and one hemiplegia. No relationship existed between these motor disabilities and serum CK‐BB activity after birth. There seemed to be a relationship between increased serum CK‐BB after birth and low scores on the Bayley Scales of Mental Development, but this did not reach statistical significance. At the age of four years, four of the five survivors with high serum CK‐BB activity after birth (> 25U/L) needed special schooling because of mental retardation. Increased serum CK‐BB activity after birth may be associated with delayed mental development, but further study is needed, especially of asphyxiated infants. RÉSUMÉ Relations entre l'activité sérique CK‐BB chez le prématuré et le devenir aux âges de deux et quatre ans La relation entre l'activité de l'iso‐enzyme sérique cérébrale spécifique créatine kinase (CK‐BB) immédiatement après la naissance et le devenir neurodéveloppemental à deux et quatre ans d'âge corrigé a été étudié prospectivement sur un groupe de prématurés (‐ 34 semaines de gestation). Sur les 35 enfants qui ont pu être suivis, sept avaient des infirmités motrices (quatre diplégies sévères, deux diplégies légères ou modérées, une hémiplégie). Aucune relation n'existait entre ces troubles moteurs et l'activité sérique CK‐BB après la naissance. Il semblait y avoir une relation entre une activité sérique CK‐BB accrue après la naissance et des scores bas aux echelles de développement mental de Bayley mais le seuil de la signification n'était pas atteint. A l'âge de quatre ans, quatre des cinq survivants avec une activité sérique CK‐BB élevée après la naissance exigeait une scolarisation spéciale en raison d'un retard mental. Les auteurs concluent que l'accroissement de l'activité sérique CK‐BB après la naissance peut être associé avec un retard du développement mental mais cela nécéssite des études ultérieures. ZUSAMMENFASSUNG Die Beziehung zwischen der Serum CK‐BB Aktivität bei Frühgeborenen und dem Outcome im Alter von zwei und vier Jahren Es wurde eine prospektive Studie über die Beziehung zwischen der Aktivität des hirnspezifischen Isoenzyms Kreatinkinase (CK‐BB) im Serum sofort nach der Geburt und dem entwicklungs‐neurologischen Outcome im korrigierten Alter von zwei und vier Jahren bei einer Gruppe von Frühgeborenen (Gestation < 34 Wochen) durchgeführt. Von den 35 Kindern, die zu den Kontrolluntersuchungen kamen, hatten sieben motorische Behinderungen (vier eine schwere Diplegie, zwei eine leichte bis mittelschwere Diplegie und eins eine Hemiplegie). Eine Relation zwischen diesen motorischen Behinderungen und der Serum CK‐BB Aktivität nach d...

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Serum creatine kinase BB as predictor of periventricular haemorrhage in preterm infants

Cited by 5 publications

References 23 publications

A systematic review and meta-analysis of the timing of early intraventricular hemorrhage in preterm neonates: Clinical and research implications

A systematic review and meta-analysis of the timing of early intraventricular hemorrhage in preterm neonates: Clinical and research implications

Pathophysiology of Intraventricular Hemorrhage in the Neonate

Serum Ck‐bb Activity in the Preterm Infant and Outcome at Two and Four Years of Age

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