Serum Cystatin C Is a Determinant of Paraoxonase Activity in Hemodialyzed and Renal Transplanted Patients

Varga, Éva; Serés, I.; Harangi, Mariann; Sztanek, Ferenc; Asztalos, László; Löcsey, L.; Borbás, Béla; Szegedi, János; Kárpáti, István; Paragh, György

doi:10.1155/2009/819862

Cited by 13 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study with 74 hemodialized, 171 renal transplanted patients, and 110 healthy controls, a negative correlation was found between PON1 activity and cystatin C level [43]. Homocysteine level correlated negatively with PON1 activity, and positively with cystatin C level.…”

Section: Association With Other Biomarkersmentioning

confidence: 99%

See 1 more Smart Citation

Paraoxonase 1 in Chronic Kidney Failure

2012

View full text Add to dashboard Cite

In this review we summarize the findings from the literature and our own laboratory on the decreased PON1 activity in renal failure, the mechanisms proposed and the effect of interventions. In addition to profound alterations in lipoproteins, reduced serum PON1 activity has been clearly established in the past decade and could contribute to accelerated development of atherosclerosis in ESRD and in HD. PON1 lactonase activity is lower in ESRD patients. Hemodialysis partially restores PON1 lactonase and the other activities. PON1 activity recovery after dialysis suggests that uremic toxins may play a mechanistic role in PON1 inactivation. Lower PON1 activity in CRF patients is associated with low thiol concentration, high CRP, and is beneficially enhanced with vitamin C and flavonoids. Changes in HDL subclasses, namely lower HDL3 in these patients may also play a role in PON1 lower activity. Future research should focus on: (1) mechanistic studies on causes for low PON1 activity and mass; (2) prospective studies focusing on whether there is an added predictive value in measuring PON1 activity (and PON1 activity in HDL3) in this patient population; (3) intervention studies attempting to increase PON1 activity.

show abstract

Section: Association With Other Biomarkersmentioning

confidence: 99%

“…OxLDL and lipoperoxide levels were significantly higher in the renal patients. Cystatin C may be a good predictive factor for homocysteine levels but for the antioxidant status in patients with renal failure [42, 43]. …”

Section: Association With Other Biomarkersmentioning

confidence: 99%

Paraoxonase 1 in Chronic Kidney Failure

2012

View full text Add to dashboard Cite

show abstract

“…9 The activity of this enzyme is reduced in patients with enhanced atherosclerosis, in disorders of lipoprotein metabolism, in renal insufficiency and after renal transplantation, caused by elevated oxidative stress and disturbances of apolipoprotein metabolism. 10 Given that increased oxidative stress has been observed in patients with cardiovascular diseases, the use of nutritional antioxidants for the attenuation of atherosclerosis development has been suggested. 11 In fact, supplementation with antioxidant agents is reported to rescue renal epithelial cells from oxalate-induced generation of reactive oxygen species (ROS), lipid peroxidation and other toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Phytotherapy in a rat model of hyperoxaluria: the antioxidant effects of quercetin involve serum paraoxonase 1 activation

Amengual-Cladera

Nadal-Casellas

Gómez-Pérez

et al. 2011

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Serum paraoxonase 1 (PON1) has been reported to be an important contributor to the antioxidant and anti-inflammatory activities of HDL, avoiding LDL oxidation. The activity of this enzyme is reduced in patients with renal insufficiency, caused by elevated oxidative stress and disturbances of apolipoprotein metabolism. Therapeutic utilization of antioxidants to control renal oxidative stress may be an effective therapy in renal protection. The aim was to investigate the protective effects of several antioxidant compounds against the oxidative stress associated to renal failure induced by ethylene glycol (EG), focusing on the possible role of serum PON1 activity. Fifty-four male Wistar rats were randomly assigned to six groups (n = 9): an untreated control (C) group, an EG-treated group, a catechin (CAT)-treated group, an epicatechin (EPI)-treated group, a quercetin (QUE)-treated group and a folk herbal extract (FHE)-treated group. After 16 d of treatment, calcium oxalate lithiasis was induced in the rats using EG. After eight days (treatment + EG), the animals were sacrificed. EG treatment impaired kidney composition, increased oxidative damage, and decreased serum paraoxonase and arylesterase activities. CAT, QUE and the FHE Fagolitos improved oxidative status by enhancing antioxidant defenses - superoxide dismutase and PON1 activities - and reducing oxidative damage, thus reinforcing the idea of a possible role of PON1 in the protective effects of QUE against the deleterious consequences of oxidative stress in kidney.

show abstract

“…GGT, the principal enzyme responsible for extracellular catabolism of the antioxidant glutathione, has been reported to be involved in oxidative stress and lipid peroxidation, and elevated under oxidative stress conditions [24]. CysC, a 13-kDa endogenous cysteine proteinase inhibitor, has been found to be positively associated with proin ammatory cytokines c-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) and marker of oxidative stress homocysteine levels, and negatively with antioxidant paraoxonase 1 activity across a variety of populations [25,26]. NLR, de ned as the neutrophil count divided by lymphocyte count, has recently been increasingly recognized as a marker of systemic in ammation [21].…”

Section: Discussionmentioning

confidence: 99%

Serum Albumin Was Negatively Associated With Diabetic Peripheral Neuropathy in Chinese Population: A Cross-sectional Study

Yan

Tang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Studies that investigated the association between serum albumin and the risk of diabetic peripheral neuropathy (DPN) have reported inconsistent results. The objective of this study was to explore the relationship between serum albumin and DPN in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: Serum albumin levels were measured in 1465 patients with T2DM aged 16–89 years. The relationships between serum albumin and the prevalence of DPN and other parameters were analyzed. Results: Patients in the highest quartile of serum albumin had lower prevalence of DPN compared with subjects in the lowest quartile (P <0.01). Serum albumin was positively associated with DBP, total cholesterol, triglycerides, high-density lipoprotein cholesterol, uric acid, and negatively with glycated hemoglobin A1c, γ-glutamyltransferase, cystatin C, serum creatinine, albumin- to-creatinine ratio, neutrophil-to-lymphocyte ratio, vibration perception thresholds (VPT), and prevalence of DPN after adjustments for age, gender, body mass index, and diabetic duration ( P<0.01 or P<0.05). There was an 50.1% decreased risk of DPN (95% confidence interval [CI] 0.404-0.544; P <0.01) per 1 SD increase of serum and 62.7% decreased risk of DPN in quartile 4 of serum albumin versus quartiles 1, 2, and 3 (95% CI 0.195-0.714; P=0.003) after multivariate adjustment. Serum albumin could predict DPN with 65.88% sensitivity and 66.7% specificity for the best cutoff value of 39.95 g/L. Conclusions: These findings suggest that lower serum albumin might be associated with the presence of DPN via increased oxidative stress, inflammation, and vasculopathy. Further larger and prospective studies are needed to confirm our findings.

show abstract

Serum Cystatin C Is a Determinant of Paraoxonase Activity in Hemodialyzed and Renal Transplanted Patients

Cited by 13 publications

References 24 publications

Paraoxonase 1 in Chronic Kidney Failure

Paraoxonase 1 in Chronic Kidney Failure

Phytotherapy in a rat model of hyperoxaluria: the antioxidant effects of quercetin involve serum paraoxonase 1 activation

Serum Albumin Was Negatively Associated With Diabetic Peripheral Neuropathy in Chinese Population: A Cross-sectional Study

Contact Info

Product

Resources

About