Serum cystatin C is associated with large cerebral artery stenosis in acute ischemic stroke

Abstract

Large cerebral artery stenosis is a major cause of acute ischemic stroke (AIS); however, the correlation between serum cystatin C (CysC) and the stenosis of large cerebral arteries in patients with AIS has not been established. We performed a retrospective review of acute ischemic stroke patients, who were examined by cerebral digital subtraction angiography(DSA). Participants (252 cases) included 131 patients without stenosis and 121 patients with large cerebral artery stenosis. Serum CysC levels in patients with large cerebral artery stenosis were much higher than that of control subjects (p<0.001). However, serum CysC levels were not related to the location of stenosis. Further, logistic regression analyses showed that increased serum CysC was an independent risk factor of large cerebral artery stenosis in patients with acute ischemic stroke. Total participants were subdivided into quintiles based on serum CysC levels. Compared with the first quintile, the odds ratios of risk for large cerebral artery stenosis in the fourth and the fifth quintile were 1.26 (p<0.05) and 4.71(p<0.05) respectively, after the adjustment for age, sex, and smoking, hypertension, type 2 diabetes mellitus(DM), dyslipidemia, creatinine(Cr), urea, uric acid, and C reactive protein(CRP). Therefore, a significant positive correlation was observed between elevated serum CysC levels and large cerebral artery stenosis in patients with acute ischemic stroke. In summary, our findings provide new insights into the correlation between increased serum CysC and large cerebral artery stenosis in patients with acute ischemic stroke.

Cystatin C as a predictor for carotid artery steno-occlusive disease in non-cardioembolic ischemic stroke

“…Therefore, CysC acts as a good biomarker for acute ischemic stroke. Going with our result, Xu and colleagues [6] noticed that elevated CysC levels were strongly associated with stroke. Yang and colleagues [7] have similar results and hypothesized that Cyst C plays an important role in the pathogenesis of atherosclerosis.…”

“…Matching with our study result, Xiao and colleagues [8] and Huang and colleagues [16] found that CysC levels were not correlated with serum total cholesterol, high-density lipoprotein, and low-density lipoprotein levels. While on the contrary, Xu and colleagues [6] observed a significant correlation with serum CysC levels and serum triglycerides and cholesterol.…”

“…In the current study, a positive correlation was found between CysC level and NIHSS scores with statistical significance, so we concluded that CysC is a prognostic tool for stroke severity as the higher the CysC level, the severer the stroke. Zhiqiang and colleagues [6] show a positive correlation between CysC and NIHSS. While Zeng and colleagues [9] observed that correlation between CysC levels and NIHSS was not significant, that was conversely, to our results due to our selection criteria as our patients were in the first week of stroke.…”

Evaluation of nephrocerebral risk with the use of cystatin C in patients with chronic kidney disease

“…Z. Xu и соавт. [27] показали, что у пациентов с церебральным инсультом и атеросклерозом сонных артерий достоверно повышен уровень цистатина С в плазме крови. Примечательно, что в настоящем исследовании пациенты в исследуемых группах были сопоставимы по параметрам гемодинамики, полу, возрасту, липидному составу крови.…”

Association between Serum Cystatin C and Vascular Complications in Type 2 Diabetes Mellitus without Nephropathy

“…A recent study has shown that high CysC levels are associated with CHD in type 2 diabetes mellitus patients [10]. Serum CysC is also reported to be independently associated with cerebral artery stenosis in ischemic stroke patients [11]. However, few studies have evaluated the relationship between CysC and vascular complications in type 2 diabetes mellitus patients.…”