Serum eosinophil cationic protein in children with atopic dermatitis

Murat-Sušić, Slobodna; Lipozenčić, Jasna; Žižić, Vesna; Husar, Karmela; Marinović, Branka

doi:10.1111/j.1365-4632.2006.02865.x

Cited by 18 publications

(5 citation statements)

References 34 publications

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“…falciparum coinfection among males than females since ECP levels were highest among the coinfected group. The observed positive correlation between relative eosinophil count and ECP level agrees with previous studies [22, 23], while others [20] found no such association. Immune responses to hookworm larvae involve a series of cellular and molecular interactions with immunoglobulin E-activated mast cells [24].…”

Section: Discussionsupporting

confidence: 92%

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Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana

et al. 2019

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BackgroundThe eosinophil cationic protein (ECP) is a cytotoxic protein mainly secreted by eosinophils granulocytes and plays a role in host defense against parasitic infections. Infection with Necator americanus (hookworm) is traditionally diagnosed by the Kato-Katz method which is inherently tedious, subjective and known to underestimate infection intensity. This study aimed to assess levels of serum ECP in relation to hookworm infection intensity.MethodsStool samples from 984 (aged 4 to 80 years) participants in a cross-sectional study conducted in the Kintampo North Municipality of Ghana were examined using the Kato-Katz and formol-ether concentration methods. Serum ECP levels were measured by ECP assay kit and compared between 40 individuals infected with hookworm only, 63 with hookworm- Plasmodium falciparum co-infection, 59 with P. falciparum infection and 36 with no infection.ResultsHookworm infection prevalence was 18.1% (178/984). ECP levels were significantly higher in individuals infected with hookworm only (β = 2.96, 95%CI = 2.69, 3.23, p<0.001) or co-infected with P. falciparum (β = 3.15, 95%CI = 2.91, 3.39, p<0.001) compared to the negative control. Levels of ECP were similar between those with only P. falciparum infection and the uninfected control (p>0.05). Increased hookworm intensity was associated with a significant increase in ECP level (β = 4.45, 95%CI = 2.25, 9.11, rs = 0.193, n = 103, p<0.01). ECP threshold of 84.98ng/ml was associated with a positive predictive value (PPV) of 98% (95% CI = 92, 100), and negative predictive value (NPV) of 76% (95% CI = 62, 87) in classifying hookworm infection status with an AUROC of 96.3%.ConclusionSerum ECP level may be a good biomarker of hookworm infection and intensity and warrant further investigations to help improve current hookworm diagnosis.

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Section: Discussionsupporting

confidence: 92%

“…falciparum alone and those with no infections. However, other parasitic infections as well as allergies have been associated with elevated plasma ECP levels [21–23] and should be accounted for in studies investigating its association with any specific infection.…”

Section: Discussionmentioning

confidence: 99%

Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana

et al. 2019

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“…parasitic infection, certain cancers and autoimmune diseases). 28, 30, 31 Increases in tissue mast cells and peripheral eosinophil counts have also been evaluated, but with similar inconsistent association. 30, 32–34 …”

Section: Biomarkersmentioning

confidence: 99%

Guidelines of care for the management of atopic dermatitis

Eichenfield

Tom

Chamlin

et al. 2014

Journal of the American Academy of Dermatology

988

375

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Atopic dermatitis (AD) is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2–3% of adults. This guideline addresses important clinical questions that arise in AD management and care, providing updated and expanded recommendations based on the available evidence. In this first of four sections, methods for diagnosis and monitoring of disease, outcomes measures for assessment and common clinical associations that affect patients with AD are discussed. Known risk factors for the development of disease are also reviewed.

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“…Correlation between serum IgE levels and AD severity has been suggested, but study results are partly conflicting ( 10 , 11 ). A recent study combining panimmunoglobulin IA for 2–4 days with subsequent biweekly omalizumab treatment for 6 months showed that after initial reduction in total serum IgE levels by IA, free IgE levels continued to fall during omalizumab administration and began to increase again during treatment-free follow-up.…”

Section: Discussionmentioning

confidence: 99%

IgE-Selective Immunoadsorption for Severe Atopic Dermatitis

et al. 2018

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IntroductionRecent reports proposed the application of immunoadsorption (IA) for patients with recalcitrant atopic dermatitis (AD) and high-serum IgE levels. However, experience with this novel treatment approach, especially with the newly available IgE-specific adsorber, is limited and recommendation for its use in clinical practice awaits evidence from more studies.Materials and methodsPatients with severe AD (SCORAD ≥ 60) and total serum IgE levels ≥750 kU/L were included in this study. The treatment protocol consisted of two cycles of five consecutive treatments with IgE-selective IA 3 weeks apart.ResultsTen patients were enrolled and four patients completed the study. The mean SCORAD was significantly improved by up to 43% within a few weeks and until the end of a 6-month follow-up period, with 50% of patients achieving an at least 50% individual reduction of the baseline SCORAD. Each IA cycle induced a temporal average decrement of total serum levels of IgE, IgM, IgA, and IgG by 92, 43, 38, and 35%, respectively. Except for one case of Staphylococcus aureus septicemia, no major adverse events occurred.ConclusionAlthough limited by a considerable withdrawal rate, our observations strengthen our and other recent results further suggesting that IgE-selective IA is an effective treatment option for patients severely affected by AD with highly elevated IgE levels.

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Serum eosinophil cationic protein in children with atopic dermatitis

Abstract: Background: Eosinophil cationic protein (ECP) is a cytotoxic agent secreted

Cited by 18 publications

References 34 publications

Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana

Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana

Guidelines of care for the management of atopic dermatitis

IgE-Selective Immunoadsorption for Severe Atopic Dermatitis

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