Serum Eosinophil Cationic Protein Level in Chinese Subjects with Nonallergic and Local Allergic Rhinitis and its Relation to the Severity of Disease

Cheng, Ke‐Jia; Xu, Yingying; Liu, Hongyan; Wang, Shenqing

doi:10.2500/ajra.2013.27.3845

Cited by 44 publications

(47 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only one study has reported the evidence that LAR existed in Chinese subjects [7]. That study showed there was no difference between LAR and NAR patients with regard to the clinical symptoms, which was in contrast to findings in Caucasian patients.…”

contrasting

confidence: 46%

“…The current studies demonstrated the patterns and phenotypes of LAR patients from mainland China, where there is a dearth of research in LAR, with only 1 existing study in Chinese patients [7]. We found that the proportion (19.0%) of LAR among the IR subjects in our study was lower than the results reported in Western countries (e.g., Spain 54-62.5%) but similar to other Asian countries (e.g., Korea 10.8%) [3,4,6].…”

Section: Discussionmentioning

confidence: 99%

“…The above studies were carried out in Caucasians in European countries. The prevalence of LAR in IR patients in other populations has also been reported: 8.2% in eastern China, 10.9% in Korea [6,7], and 84.6% in Saudi Arabia [8]. The difference in prevalence rates indicates that genetic and environmental factors could affect the incidence of LAR.…”

mentioning

confidence: 97%

See 2 more Smart Citations

Clinical Characteristics and Allergen Sensitization Patterns of Patients with Local Allergic Rhinitis in Southern China

Tao¹,

Chen³

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Local allergic rhinitis (LAR) is characterized by the production of specific IgE (sIgE) in the nasal mucosa without evidence of systemic atopy. The characteristics of LAR in Caucasians have been well documented. LAR is understudied in China, with prevalence, patient demographics, symptomatology, and the allergen sensitization profile being poorly understood. The purpose of this study is to investigate the demographics, characteristics, and allergen sensitization profile of patients with LAR in Southern China. Methods: A total of 194 patients with rhinitis and 13 healthy subjects were enrolled in the current study. The patients' demographic data, clinical history, and symptoms were recorded. Local and systemic sIgE to a wide panel of specific allergens were measured in the nasal secretion and serum samples. Results: Among the rhinitis patients, 115 were classified as allergic rhinitis (AR; 59.3%), 15 as LAR (7.7%), and 64 as non-AR (33.0%). The demographic characteristics, duration, frequency, and severity of symptoms were similar, although LAR exhibited higher symptom scores for nasal itch. Monosensitization was the predominant pattern of sensitization in both AR (109 out of 115, 95%) and LAR (14 out of 15, 93%). House dust mite was the dominant allergen in AR patients (109 out of 115, 95%), while pollen was the dominant allergen in LAR patients (11 out of 15, 73%). Conclusion: The prevalence of LAR patients in Southern China was 7.7%. Pollen was the most common sensitizing allergen for the local LAR patients, which differs from Caucasian studies, in which house dust mite was the dominant sensitizing allergen. Monosensitization was the predominant pattern in both AR and LAR.

show abstract

contrasting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Characteristics and Allergen Sensitization Patterns of Patients with Local Allergic Rhinitis in Southern China

Tao¹,

Chen³

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Based on the obtained results, D. pteronyssinus was the predominant allergen that caused AR or LAR in the analyzed groups, a result in agreement with previous data, which showed that D. pteronyssinus may have great importance in the induction of LAR among various age groups [11,12]. The course of nasal symptoms, regardless of severity, in this type of allergy can mimic chronic non-AR; therefore, in a significant group of patients, the true diagnosis of LAR was significantly delayed.…”

Section: Discussionsupporting

confidence: 79%

Local Allergic Rhinitis in Adult Patients with Chronic Nasal Symptoms

Krajewska-Wojtys¹,

Jarząb²,

Zawadzińska³

et al. 2017

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Local allergic rhinitis (LAR) remains an underdiagnosed condition characterized by the local production of IgE antibodies during the natural exposure to aeroallergens. The prevalence of LAR in adult patients with a previous diagnosis of non-AR was assessed. Material and Methods: Eighty-four patients with perennial nasal allergy symptoms but a negative skin prick test and specific IgE antibodies against common inhalant allergens were included in the study. Nasal provocation tests were performed with the inhalant allergens Dermatophagoides pteronyssinus, Alternaria, and cat allergen, followed by the detection of nasal-specific IgE antibodies in the lavage during the challenge. Results: LAR was confirmed in 21 (25%) study patients. In the remaining 63 (75%) patients, non-AR was diagnosed. In addition, LAR was found following exposure to D. pteronyssinus in 19 (22.6%) patients, Alternaria in 3 (3.6%) patients, and the cat allergen in 1 (1.2%) patient. In 2 patients, concomitant allergies to D. pteronyssinus and Alternaria were observed. Conclusion: LAR can be a form of chronic perennial rhinitis that has previously been considered to be non-AR.

show abstract

“…However, eosino-phil derived proteins such as eosinophil derived neurotoxin (EDN) and major basic protein (MBP), and the mean peripheral blood eosinophils (PBE) count have proven to be significantly higher in patients with EoE, both in serum and histological samples (EDN and MBP). Eosinophil cationic protein (ECP) in serum has proven to be effective in the clinical monitoring of asthma and allergic rhinoconjunctivitis (6). However, its role in EoE has not been studied in depth.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of serological markers of eosinophil activity in monitoring eosinophilic esophagitis

Rodríguez-Sánchez¹,

Torrijos

de-la-Santa-Belda

et al. 2013

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Background: it is necessary to find serological markers accessible in clinical practice to prevent the need to perform repeated endoscopies.Objective: to assess the efficacy of eosinophil activity markers in monitoring eosinophilic esophagitis (EoE).Material and methods: thirty patients were included prospectively, all under dietary treatment -diets excluding 6 foods, and allergy test based diet (skin prick test and specific IgE). The variables assessed were demographic parameters, eosinophil cationic protein (ECP) levels (μg/mL), total IgE (KU/L), peripheral blood eosinophils (PBE) (U/mm 3 ), and the maximum peak of eosinophils/hpf in esophageal biopsies. The variation found between these figures was assessed in line with response to dietary treatment.Results: thirty patients (66.7 % males; mean age 33.43 years) were included in the study, 22 responders and 8 non-responders. Ninety percent presented a personal history of atopy. No significant decrease was detected in serum total IgE and ECP after diet in responder and nonresponders. However, the PBE decreased significantly in responders but not in nonresponders, PBE in responders (pre-diet. 397.27 vs. post-diet 276.81, p = 0.024) and non-responders PBE (pre-diet. 460 vs. post-diet 317.5, p = 0.23).Conclusion: serum total IgE and ECP do not act as markers for EoE activity. However PBE may play a role in this regard, bearing in mind that this parameter may be influenced by concomitant atopic conditions.

show abstract

Serum Eosinophil Cationic Protein Level in Chinese Subjects with Nonallergic and Local Allergic Rhinitis and its Relation to the Severity of Disease

Cited by 44 publications

References 24 publications

Clinical Characteristics and Allergen Sensitization Patterns of Patients with Local Allergic Rhinitis in Southern China

Clinical Characteristics and Allergen Sensitization Patterns of Patients with Local Allergic Rhinitis in Southern China

Local Allergic Rhinitis in Adult Patients with Chronic Nasal Symptoms

Effectiveness of serological markers of eosinophil activity in monitoring eosinophilic esophagitis

Contact Info

Product

Resources

About