Serum estradiol above the postmenopausal level after chemotherapy-induced amenorrhea in breast cancer patients

Braverman, Albert S.; Sawhney, Harindar; Tendler, Aron; Patel, Nilesh H.; Rao, Sujatha; El‐Tamer, Mahmoud; Kamenova, Boriana; Weedon, Jeremy

doi:10.1586/14750708.3.5.609

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the study of Braverman et al in patients with breast cancer who received chemotherapy found that all study subjects experienced amenorrhea at 1-34 months after chemotherapy, and the chemotherapy regimen administered was associated with estradiol levels after amenorrhea [18]. One study also evaluated the effect of anthracycline chemotherapy in patients with ABC and its effect on estradiol and tumor size.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy Effect on Estradiol Levels in Patients with Triple-negative Breast Cancer: A Clinical Prospective Study from Indonesia

Septiani

Soewoto

Bagus

2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

Research Background: This study aimed to scrutinize the chemotherapy’s effect on estradiol levels in patients with triple-negative breast cancer (TNBC) at low-resource country. Methods: This prospective analytic observational cohort study involved patients with TNBC who had undergone surgery and had never received chemotherapy or hormonal therapy before. Patients were checked for estradiol levels before and after chemotherapy. This study was conducted at the Surgical Oncology Department of Regional Public Hospital Dr. Moewardi, Surakarta Indonesia, from April 2020 to March 2021. Descriptive data were presented in a frequency table based on age, menopausal status, parity status, breastfeeding status, hormonal contraception, hormonal contraception duration, family history, stage, and histological grade. Differences in estradiol changes before and after chemotherapy (mean+sd) were then reported. Results: From a total of 23 patients, 21 patients (91.3%) experienced a decrease in estradiol levels, while two patients (8.7%) underwent an increase in serum estradiol levels after chemotherapy. The mean decrease was 11.57 pg/ml. The two samples that experienced an increase in estradiol levels had a mean increase of 16.5 pg/ml. There was a significant difference between estradiol levels before and after undergoing chemotherapy, with p-value=0.001. Conclusions: In this research, chemotherapy reduced estradiol levels in TNBC patients. Statistically significant reductions in estradiol levels were based on the disease stage.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemotherapy Effect on Estradiol Levels in Patients with Triple-negative Breast Cancer: A Clinical Prospective Study from Indonesia

Septiani

Soewoto

Bagus

2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…In young women, the status of ovarian function cannot be determined from menstrual status unless they have undergone bilateral oophorectomy. The decrease in serum estradiol levels is a reference to the success of breast cancer therapy, by means of surgery such as oophorectomy or drugs that interfere with ovarian function [ 3 - 5 ].…”

Section: Introductionmentioning

confidence: 99%

Estradiol Levels and Chemotherapy in Breast Cancer Patients: A Prospective Clinical Study

Soewoto

Agustriani

2023

World J Oncol

View full text Add to dashboard Cite

Background: Breast cancer remains a global health issue, including in Indonesia, which has a relatively high incidence of breast cancer. Several theories have proved the role of estrogen in breast cancer carcinogenesis, but there is yet to be a preventive measure against breast cancer. Chemotherapy is one of the therapeutic modalities for breast cancer that disturbs ovarian function in producing estrogen due to damaged ovarian granulosa cells. Chemotherapy becomes an alternative option to decreasing circulating estradiol levels through interventions in ovarian functions, either by surgery, such as oophorectomy, or medications that disturb the ovarian functions. This study aimed to observe the estradiol levels in breast cancer patients before and after chemotherapy. Methods:This was a prospective cohort study. We observed the estradiol levels before and after adjuvant chemotherapy in breast cancer patients. Subjects' characteristics are presented in mean ± standard deviation, distribution frequency, and percentage. Subjects' characteristics based on chemotherapy were tested using an independent ttest, Mann-Whitney U, and Chi-square/Fisher exact test. Effects of chemotherapy on estrogen levels were tested using the Wilcoxon rank test and Kruskal-Wallis test.Results: A total of 194 research subjects were included. There were changes in estradiol levels before and after therapy. The decrease of estradiol levels in patients who did not receive chemotherapy was -6.9% (P > 0.05). Patients who received anthracycline cyclophosphamide (AC) regimen, paclitaxel and anthracycline (TA) regimen, paclitaxel, anthracycline and trastuzumab (TA + H) regimen, and platinum regimen experienced a significant decrease in estradiol levels (-21.4% (P < 0.05), -20.2% (P < 0.001), -31.7% (P < 0.01), and -23.7% (P < 0.05), respectively). Among chemotherapy groups, the estradiol levels before and after chemotherapy did not have significant differences (P = 0.937 and P = 0.730, respectively). Conclusion:There are no significant differences in estradiol levels between chemotherapy and hormonal therapy groups. Patients in both groups have decreased estradiol levels after therapy, although patients in hormonal therapy do not experience as much decrease as those in chemotherapy.

show abstract

Serum estradiol above the postmenopausal level after chemotherapy-induced amenorrhea in breast cancer patients

Cited by 2 publications

References 15 publications

Chemotherapy Effect on Estradiol Levels in Patients with Triple-negative Breast Cancer: A Clinical Prospective Study from Indonesia

Chemotherapy Effect on Estradiol Levels in Patients with Triple-negative Breast Cancer: A Clinical Prospective Study from Indonesia

Estradiol Levels and Chemotherapy in Breast Cancer Patients: A Prospective Clinical Study

Contact Info

Product

Resources

About