Serum Exosomal microRNA Profiling in AIDS Complicated with Talaromyces marneffei Infection

The extracellular vesicles in HIV infection and progression: mechanisms, and theranostic implications

“…Some certain miRNAs, particularly miR-192-5p, miR-194-5p, and miR-1246, were significantly upregulated in serum extracellular vesicles from AIDS patients with Talaromyces marneffei (TM) infection. The combination of these three miRNAs had an area under the curve (AUC) of 0.742, with a sensitivity of 56.8% and a specificity of 86.1% in predicting the presence of AIDS in conjunction with TM infection, which showed potential as non-invasive biomarkers for early diagnosis of AIDS in patients with TM infection ( Ning et al, 2021 ) ( Figure 5 ).…”

“…Their dual role in both activating and suppressing immune functions, their impact on T-cell modulation, and their potential in therapeutic and vaccine development make them a significant focus in HIV research and treatment strategies. MiR-192-5p, miR-194-5p, and miR-1246 are involved in important signaling pathways such as TGF-β, AMPK, cAMP, Wnt, and MAPK signaling pathways in HIV patient with Talaromyces marneffei (TM) concurrent infection ( Ning et al, 2021 ). TAR RNA in EVs from HIV-1 infected cells could be a potential target for cancer therapeutics in HIV patient coinfected with cancer ( Sharma, 2019 ).…”