Serum fatty acids, antioxidants, and treatment response in hepatitis C infection: Greater polyunsaturated fatty acid and antioxidant levels in hepatitis C responders

Irmisch, G.; Hoeppner, Jacqueline; Thome, Johannes; Richter, J.; Fernow, Anja; Reisinger, Emil C.; Lafrenz, Michael; Loebermann, Micha

doi:10.1016/j.jacl.2011.04.005

Cited by 8 publications

(2 citation statements)

References 27 publications

(24 reference statements)

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“…HCV core protein has been shown to significantly increase the proportion of oleic acid, but not palmitic acid, in the livers of patients with HCV infection. Irmisch et al [ 27 ] compared FAs in serum of female patients with untreated chronic HCV infection with those treated with interferon-α and ribavirin and healthy controls. They showed that women who responded to treatment and healthy controls had significantly higher levels of eicosapentaenoic and arachidonic acid than did untreated HCV patients.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

2015

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BackgroundTo study the effect of Interferon (INF) alpha-2b therapy on the serum lipids and fatty acid (FA) level in pre and post treated hepatitis C (HCV) patients.MethodsFifty samples were collected from pre and post treated patients along with age and gender matched controls. After separating serum, lipid contents were analyzed by microlab and gas chromatography.ResultsThe hepatitis C infection results in hypolipidemia with reduced level of triglyceride (113 mg/dl), high density lipoprotein (37.1 mg/dl), low density lipoprotein (74.3 mg/dl), cholesterol (149.9 mg/dl) that increase the infection resolution and after the IFN treatment, the lipid profile of the patients were increased. The myristic (2.8 g/100 g) and palmitic acids (26.6 g/100 g) were significantly higher while linoleic acid (20.94 g/100 g) was significantly lower in HCV patients. The higher oleic: stearic (1.4) and palmitoleic: palmitic acid (0.2) ratios were detected in HCV patients, showing enhanced stearoyl-CoA desaturase activity. The levels of serum saturated (44.9 g/100 g) and monounsaturated FA’s (26.98 g/100 g) were higher while polyunsaturated FA’s (25.9 g/100 g) were found lower in HCV patients in comparison of controls (40.1; 25.01; 33.44 g/100 g respectively). An inverse correlation was found HCV RNA viral load and PUFA (R2 = 0.4555). Elevated levels of serum saturated free FA (45.7 g/100 g) in HCV patients indicates stimulated lipoapoptosis.ConclusionThe present study conclude that serum PUFA level was lower in HCV patients, hence PUFA may provide synergistic antiviral effects when given as a food supplement during the INF based anti- HCV therapy.

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Section: Discussionmentioning

confidence: 99%

A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

2015

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“…Black seed has immunomodulatory effect [27]. Olive oil contains fat soluble vitamins specially vitamin D and also rich in linoleic acids that has decreasing effect on HCV replication [28]. This work was conducted to determine the efficacy of combination of safe natural product; blue green ® tablet, vitamin D3, black seeds, olive oil and honey; and chloroquine in treating naive patients with chronic hepatitis C and non-responders to combined IFN/RBV treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of Combination of Some Natural Products and Chloroquine on HCV Infection in Egyptian Patients: Pilot Study

Sheir¹,

Badra²,

Salama³

2013

J Liver

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Background: Studies using safe natural products {Blue green ® tablet (Rhodiola rosea L. root dry extract; Eleutherococcus senticosus Maxim. root dry extract; Ginkgo biloba L. leaf dry extract; Klamath microalgae Aphanizomenon flos aquae (AFA) 50 mg)} showed its antiviral effect. As well as vitamin D3, linolenic acid, black seeds and honey. The aim of the study was to determine the efficacy of combination of these natural products and chloroquine in treatment of HCV patients refusing or unfit for combined Interferon and Ribavirin (INF/RBV) therapy or HCV patients who failed to achieve sustained virological response to INF/RBV. Methods: Patients with detectable HCV RNA with different stages of fibrosis and cirrhosis refusing or unfit for combined Interferon Ribavirin (INF/RBV) therapy or patients who failed to achieve sustained virological response to INF/RBV from April 2009 to March 2012 were included in this study. All the patients were treated first from coinfection as schistosomiasis and helicobacter pylori if present then received combination Blue green ® tablet-original natural company, Italy; 2 tablet/30 kg once daily; Vitamin D: 1000 IU/day; tablespoon filled with paste made of linolenic acid, black seeds powder and honey; and 250 mg chloroquine once daily for 10 days and then every 3 days through the duration of therapy.Results: 195 patients with chronic HCV were included; mean age 47.8 ± 9.03 years, 67.7% males. All patients have chronic hepatitis. 24 patients had cirrhosis. 82 (42.1%) achieved negative HCV RNA after 6 months of treatment. After 12 months of treatment, 107 (54.9%) patients had negative HCV RNA. 125 (64.3%) patients achieved ETR after 18 months of treatment. Moreover, 4/6 (66.6%) patients with combined HCV and HBV showed undetectable HBV after 3 months. Two out of 8 (25%) patients who failed to achieve SVR with previous (INF/RBV) have ETR. Conclusion:Combination of safe natural products (Blue green ® tablet, vitamin D3, linolenic acid, black seeds and honey) and chloroquine may have a role to achieve SVR in combination with recent direct acting antiviral drugs for HCV infection.

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High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon‐Based Therapy for Hepatitis C Virus

Miyake¹,

Hiasa²,

Hirooka³

et al. 2012

Lipids

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Hepatitis C virus (HCV) infection alters fatty acid synthesis and metabolism in association with HCV replication. The present study examined the effect of serum fatty acid composition on interferon (IFN)-based therapy. Fifty-five patients with HCV were enrolled and received IFN-based therapy. Patient characteristics, laboratory data (including fatty acids), and viral factors that could be associated with the anti-HCV effects of IFN-based therapy were evaluated. The effects of individual fatty acids on viral replication and IFN-based therapy were also examined in an in-vitro system. Multivariate logistic regression analysis showed that the level of serum palmitic acid before treatment and HCV genotype were significant predictors for rapid virological response (RVR), early virological response (EVR), and sustained virological response (SVR). High levels of palmitic acid inhibited the anti-HCV effects of IFN-based therapy. HCV replication assays confirmed the inhibitory effects of palmitic acid on anti-HCV therapy. The concentration of serum palmitic acid is an independent predictive factor for RVR, EVR, and SVR in IFN-based antiviral therapy. These results suggest that the effect of IFN-based antiviral therapy in patients with HCV infection might be enhanced by treatment that modulates palmitic acid levels.

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Serum fatty acids, antioxidants, and treatment response in hepatitis C infection: Greater polyunsaturated fatty acid and antioxidant levels in hepatitis C responders

Cited by 8 publications

References 27 publications

A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

A comparative study of serum lipid contents in pre and post IFN-alpha treated acute hepatitis C patients

Effect of Combination of Some Natural Products and Chloroquine on HCV Infection in Egyptian Patients: Pilot Study

High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon‐Based Therapy for Hepatitis C Virus

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