Serum fatty acids, lipoprotein(a) and apolipoprotein composition of rural, suburban and urban populations in North Vietnam

Kieu, Nguyen Thi Minh; Yasugi, Etsuko; Lien, Do Thi Kim; Anh, Nguyễn Thị Lan; Thanh, Tran; Khoi, Ha Huy; Kido, Takamasa; Kondo, Kazuo; Itakura, Hiroshige; Chuyên, Nguyễn Văn; Yamamoto, Shigeru; Oshima, Mieko

doi:10.1046/j.1440-6047.2000.00150.x

Cited by 3 publications

(5 citation statements)

References 10 publications

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“…Maybe they are related with the custom of fish intake. Jing is an oceanic ethnic minority like Kinh populations in North Vietnam, survival relying on fishing18. Maybe there are differences in saturated fatty acid (SFA), polyunsaturated tatty acid (PUFA; n-3 PUFA and n-6 PUFA), and monounsaturated fatty acid (MUFA)19 intake to compare with the local Han population in their diet structure.…”

Section: Discussionmentioning

confidence: 99%

Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk

Guo

Yin

Yao

et al. 2016

Sci Rep

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This study is expected to investigate the association of ATP/GTP binding protein-like 4 (AGBL4), LDL receptor related protein 8 (LRP8) and proprotein convertase subtilisin/kexin type 9 (PCSK9) gene single nucleotide variants (SNVs) with lipid metabolism in 2,552 individuals (Jing, 1,272 and Han, 1,280). We identified 12 mutations in this motif. The genotype and allele frequencies of these variants were different between the two populations. Multiple-locus linkage disequilibrium (LD) elucidated the detected sites are not statistically independent. Possible integrative haplotypes and gene-by-gene (G × G) interactions, comprising mutations of the AGBL4, LRP8 and PCSK9 associated with total cholesterol (TC, AGBL4 G-G-A, PCSK9 C-G-A-A and G-G-A-A-C-A-T-T-T-G-G-A), triglyceride (TG, AGBL4 G-G-A, LRP8 G-A-G-C-C, PCSK9 C-A-A-G, A-A-G-G-A-G-C-C-C-A-A-G and A-A-G-G-A-G-C-C-C-G-A-A), HDL cholesterol (HDL-C, AGBL4 A-A-G and A-A-G-A-A-G-T-C-C-A-A-G) and the apolipoprotein(Apo)A1/ApoB ratio (A1/B, PCSK9 C-A-A-G) in Jing minority. However, in the Hans, with TG (AGBL4 G-G-A, LRP8 G-A-G-C-C, PCSK9 C-A-A-G, A-A-G-G-A-G-C-C-C-A-A-G and A-A-G-G-A-G-C-C-C-G-A-A), HDL-C (LRP8 A-A-G-T-C), LDL-C (LRP8 A-A-G-T-C and A-A-G-A-A-G-T-C-C-A-A-G) and A1/B (LRP8 A-C-A-T-T and PCSK9 C-A-A-G). Association analysis based on haplotype clusters and G × G interactions probably increased power over single-locus tests especially for TG.

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Section: Discussionmentioning

confidence: 99%

Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk

Guo

Yin

Yao

et al. 2016

Sci Rep

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“…The distribution of dietary n‐6 to n‐3 ratios showed that 80% of the urban, 90% of the suburban and nearly 100% of the rural population had ratios in the range of 5–10 : 1 (calculated from raw data). Referring to the data on North Vietnamese people, 2 we found the P/S ratios to be equal in South and North Vietnam, while the average n‐6/n‐3 ratios were lower in the South than in the North. Because this study was performed in middle‐aged people while the subjects of the study conducted in North Vietnam were adults over 18 years, there is a possibility that the habitual consumption of foods rich in n‐3 PUFA is lower in young than in older subjects.…”

Section: Discussionmentioning

confidence: 55%

“…In Vietnam, although energy intake from fat is below 15%, increasing fat consumption is a trend reported recently in urban areas 1 . In our previous study, the fat intake of Northern Vietnamese people was observed to be significantly higher in urban than in rural areas, 2 but risk factors for premature CVD assessed by serum lipid, lipoprotein (a) and apolipoprotein (Apo) profiles were not found in all of these populations 2,3 . However, because fat consumption patterns are quite different in North and South Vietnam, the purpose of this study is to collect basic data allowing appropriate improvement of dietary fat quality and quantity for the whole country.…”

Section: Introductionmentioning

confidence: 67%

“…The serum fatty acid compositions were measured by means of gas–liquid chromatography (GLC), with a Shimadzu gas chromatograph (GC‐14B; Shimadzu, Kyoto, Japan) equipped with a capillary column (silica Ulbon/HR‐SS‐10, 0.32 mm internal diameter × 50 mm). The conditions of analysis were the same as those described in our previous report 2 . The results were expressed as the percentage of the area of each fatty acid against the total area of all fatty acid peaks.…”

Section: Methodsmentioning

confidence: 99%

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Serum fatty acids, lipoprotein (a) and apolipoprotein profiles of middle‐aged men and women in South Vietnam

Kieu¹,

Yasugi²,

Hung³

et al. 2002

Asia Pac J Clin Nutr

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In Vietnam, increasing fat consumption is a trend recognized recently in urban areas. To obtain a reasonable nutrition status and prevent cardiovascular disease (CVD), it is necessary to obtain information on habitual fat intake and biochemical parameters as risk factors for CVD in Vietnamese populations. Therefore, from the analysis of serum fatty acid composition, fat consumption patterns in Vietnamese populations in South Vietnam, with different incomes, are discussed in this study. In addition, some risk factors for premature CVD, serum lipoprotein (a) and apolipoprotein concentrations are also assessed in these Vietnamese populations. The study was carried out in men and women aged 40-59 in three different districts: urban (n = 100), suburban (n = 98) and rural (n = 98). The results of serum fatty acid composition analysis reflected differences in quality fat intake among the three populations. The urban population was estimated to consume more vegetable oil but less fish than their rural counterparts. Although serum lipoprotein (a) and apolipoprotein B levels were below the ranges associated with atherogenesis, ongoing attention to dietary fat intake for the prevention of CVD in Vietnamese populations is required.

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“…In addition, environmental factors such as lifestyles and dietary habits are also closely correlated to serum lipid profiles [ 30 , 43 ]. Jing is a coastal ethnic minority, which makes a living out of fishing [ 44 ] and fish is one of the most popular dishes they eat. Fishes are rich in long-chain n-3 (ω-3) polyunsaturated fatty acids (LCn-3PUFA), which is beneficial to serum lipid profiles.…”

Section: Discussionmentioning

confidence: 99%

Association between thePINX1andNAT2polymorphisms and serum lipid levels

et al. 2017

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Jing nationality is a relatively conservative and isolated minority in China. Little is known about the association of the PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) and N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study aimed to clarify the association of 6 SNPs of the PINX1 and NAT2 and serum lipid levels in two Chinese populations. Genotyping of the SNPs was performed in 1236 Han subjects and 1248 Jing participants. Allelic and genotypic frequencies of these variants (except NAT2 rs1799931) were different between the two ethnic groups. The minor allele carriers had higher triglyceride (TG, rs11776767, rs1495743 and rs1799930), low-density lipoprotein cholesterol (rs6601530) levels and the apolipoprotein (Apo)A1/ApoB ratio (rs1495743) in Han nationality; and higher total cholesterol (rs1961456), TG (rs11776767, rs6601530 and rs1495743) and lower ApoA1 (rs6601530 and rs1799931) levels in Jing minority than the minor allele non-carriers. The SNPs were not statistically independent by the multiple-locus linkage disequilibrium analyses. The integrative haplotypes and gene-by-gene (G × G) interactions on serum lipid traits were also observed in the two populations. Association analysis based on haplotypes and G × G interactions might be powerful than single-locus tests. Differences in serum lipid profiles between the two populations might partially be attributed to these SNPs, their haplotypes and G × G interactions.

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Serum fatty acids, lipoprotein(a) and apolipoprotein composition of rural, suburban and urban populations in North Vietnam

Cited by 3 publications

References 10 publications

Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk

Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk

Serum fatty acids, lipoprotein (a) and apolipoprotein profiles of middle‐aged men and women in South Vietnam

Association between thePINX1andNAT2polymorphisms and serum lipid levels

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