Serum Ferritin as a Marker of Thyroid Hormone Action on Peripheral Tissues*

Takamatsu, Junta; Majima, Motoko; Miki, Kyoko; Kuma, Kanji; Mozai, T

doi:10.1210/jcem-61-4-672

Cited by 52 publications

(29 citation statements)

References 10 publications

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“…Several groups have reported that T 3 positively regulates serum ferritin in humans (Macaron & Macaron 1982, Van de Vyver et al 1982, Takamatsu et al 1985, Hashimoto & Matsubara 1989, Kubota et al 1993, Barnum-Huckins & Adrian 2000. Elevated serum ferritin levels were observed in hyperthyroid individuals, and levels decreased significantly after antithyroid treatment which helped to normalize T 3 levels (Macaron & Macaron 1982, Van de Vyver et al 1982, Takamatsu et al 1985, Kubota et al 1993, Barnum-Huckins & Adrian 2000.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated serum ferritin levels were observed in hyperthyroid individuals, and levels decreased significantly after antithyroid treatment which helped to normalize T 3 levels (Macaron & Macaron 1982, Van de Vyver et al 1982, Takamatsu et al 1985, Kubota et al 1993, Barnum-Huckins & Adrian 2000. Furthermore, administration of T 3 to hypothyroid individuals produced a significant increase in the serum ferritin level (Takamatsu et al 1985, Hashimoto & Matsubara 1989. Leedman et al (1996) reported that T 3 regulates the Iron response element (IRE) binding activity of the IRP.…”

Section: Discussionmentioning

confidence: 99%

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Plasma protein regulation by thyroid hormone

Kh¹,

Hy²,

Ch³

et al. 2003

Journal of Endocrinology

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Thyroid hormones (THs) regulate growth, development, differentiation and metabolic processes by interacting and activating thyroid hormone receptors (TRs). Although much progress has been made in our understanding of the transcriptional regulation of many TR target genes, little is known of the regulation of plasma protein gene expression by TRs. To investigate the role of TRs in plasma protein expression we used human hepatocellular carcinoma cell lines and carried out cDNA microarray analysis. Our results indicate that several plasma proteins including transferrin, prothrombin, angiotensinogen, haptoglobin, -2-HS-glycoprotein and chain, complement, lipoproteins and fibrinogen are up-regulated by THs. Furthermore, clusterin, -2-macroglobulin precursor, prothymosin and -fetoprotein were found to be down-regulated by THs.Transferrin, an iron-binding protein expressed in all mammals, and mainly synthesized in the liver, was investigated further. Immunoblot and Northern blot analyses revealed that exposure of HepG2-TR 1 sub-lines and HepG2-Neo cells to tri-iodothyronine (T 3 ) induced time-and dose-dependent increases in the abundance of transferrin mRNA and protein, with the extent of these effects correlating with the level of expression of TR 1. Nuclear run-on experiments indicate that this induction is functioning at the transcriptional level. Moreover, cyclohexamide treatment did not eliminate the induction of transferrin by TH. Thus, our results suggest that the induction of transferrin by TH is direct and may in fact be mediated by an as yet unidentified response element in the promoter region.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasma protein regulation by thyroid hormone

Kh¹,

Hy²,

Ch³

et al. 2003

Journal of Endocrinology

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“…The patient was a 13-year-old Japanese girl, previously reported by us (Patient A in [7]). Briefly, she was initially diagnosed as having generalized resistance to TH at the age of 11.…”

Section: Subject and Methodsmentioning

confidence: 86%

Defective Response of Body Height to Growth Hormone Treatment in Resistance to Thyroid Hormone with Short Stature.

Takamatsu

Yamano

et al. 1996

Endocr J

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ANALYSIS of case reports of generalized resistance to thyroid hormone (TH) revealed that the affected subjects frequently had a delayed bone maturation or anomalies of bone structure including stippled epiphyses and short metacarpals [1,2]. It was also recognized that 15% of subjects had a height below the fifth percentile and 8% belos the third percentile [3]. However, most measure ments were obtained in children, and it is not clea7 whether they ultimately achieved a normal height Although attempts to improve growth rate b) TH therapy were reported by several investigator [4][5][6], there have been, as far as we know of, nc reports on GH treatment in patients with resis tance to TH and short stature. In this study, wE have examined the response of height to GH treat ment together with increased doses of TH b) measuring serum concentrations of insulin-likf growth factor-1(IGF-1) during the course of treat ment. mU/L).The basal metabolic rate measured by oxygen consumption was -9 %. Her pubertal development was initiated at the age of 11. As shown in Fig. 1, her growth curve became blunted Subject and MethodsThe patient was a 13-year-old Japanese girl, previously reported by us (Patient A in [7]). Briefly, she was initially diagnosed as having generalized resistance to TH at the age of 11. Her serum fre€ thyroxine (T4) was increased at 6.81 ng/dl, but serum TSH was not appropriately suppressed (3.C

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“…Furthermore, BMR values were unchanged and no aggravation of thyrotoxicosis took place during 1-T3 administration. Takamatsu et al (1985) reported that serum ferritin level was increased by short term administration of 1-T3 and its response to thyroid hormone is useful in the diagnosis of thyroid hormone resistance. Moreover, Graninger et al (1986) reported that endoreticulum related protein such as fibronectin, ACE, factor VIII related antigen and tissue plasminogen activator were increased by 1-T3 administration in normal subjects.…”

Section: Discussionmentioning

confidence: 99%

A case of refetoff syndrome: Selective venous sampling for TSH is useful in differentiating thyroid hormone resistance from TSH secreting tumor.

Itagaki

Yoshida

Sato

et al. 1989

Tohoku J. Exp. Med.

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A 22-year old man with a goiter and clinical manifestations of mild thyrotoxicosis (finger tremor, palpitation, tachycardia) was diagnosed as a syndrome of inappropriate secretion of TSH. Serum concentrations of T4, free T4i T3 and TSH were 24.1,ug/100 ml, 4.07 ng/100 ml, 261 ng/100 ml and 1.12 ,uU/ml, respectively. Thyroidal 1311 uptake at 24 hr was 80%. The BMR was within the normal range. He had a normal TSH response to TRH (500,ug) with a peak level of 23.8pU/ml. The basal level of alpha-subunit of TSH was not elevated (0.35 ng/ml). Oral 1-T3 administration (75 and 150 ,cg daily) raised serum T3 concentration, reduced basal TSH and blunted TSH response to TRH. The diurnal variation of TSH was maintained. There was no evidence of abnormalities in the secretion of other pituitary hormones. These findings were compatible with thyroid hormone resistance. However, the presence of a microadenoma in the pituitary gland was suspected with CT scan. Bilateral and simultaneous venous sampling for TSH from inferior petrosal sinus showed no gradient in TSH concentration indicating that a TSH secreting pituitary tumor was unlikely. These data suggest that inappropriate TSH secretion in the present patient is resulted from resistance to thyroid hormone. In the present study selective venous sampling is useful to differentiate the thyroid hormone resistance from a TSH secreting tumor.thyroid hormone resistance ; venous sampling ; TSH secreting tumor Inappropriate hypersecretion of pituitary thyrotropin (TSH) is a rare disorder resulting from resistance to thyroid hormone or a TSH secreting tumor. This syndrome is characterized by elevation of serum thyroid hormones and a high or normal level of TSH. Basal levels of TSH and a-subunit and their response to

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Serum Ferritin as a Marker of Thyroid Hormone Action on Peripheral Tissues*

Cited by 52 publications

References 10 publications

Plasma protein regulation by thyroid hormone

Plasma protein regulation by thyroid hormone

Defective Response of Body Height to Growth Hormone Treatment in Resistance to Thyroid Hormone with Short Stature.

A case of refetoff syndrome: Selective venous sampling for TSH is useful in differentiating thyroid hormone resistance from TSH secreting tumor.

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