Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia

Shakaroun, Dania; Lazar, Michael H; Horowitz, Jeffrey C.; Jennings, Jeffrey

doi:10.1177/08850666221113252

Cited by 20 publications

(24 citation statements)

References 33 publications

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“…The current study considered ferritin as a predictor of ICU admission. This result was in concordance with the findings of Shakaroun et al 52 Oxidative imbalance in COVID-19 patients can be determined by measuring oxidative stress biomarkers such as MDA and antioxidant biomarkers. Our study shows a higher level of MDA in the critical group than in HCs, this is consonance with the published work by Avila-Nava et al, 25 Mehri et al 53 The reason for increasing MDA may be due to high levels of free radicals in COVID-19 that accelerate the rate of lipid peroxidation.…”

Section: Discussionsupporting

confidence: 92%

Hematological, Inflammatory, Coagulation, and Oxidative/Antioxidant Biomarkers as Predictors for Severity and Mortality in COVID-19: A Prospective Cohort-Study

Smail¹,

Babaei²,

Amin³

2023

IJGM

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Purpose Oxidative stress (OS) and inflammation are pivotal points in the pathophysiology of coronavirus disease-2019 (COVID-19). This study aims to use routine laboratory and oxidative stress/antioxidative biomarkers as predictors for the mortality of the disease. Patients and Methods This prospective cohort study, made up of 120 COVID-19 patients from emergency units in Erbil, Duhok, Kirkuk, and Sulaymaniyah cities in Iraq, from May the 1 st to May the 30 th , 2021, and 60 healthy controls (HCs) (n = 60). The patients were re-categorized into mild (n = 54), severe (n = 40), and critical (n = 26) groups based on the clinical criteria. Following admission to the hospital, blood was directly collected for measuring routine laboratory biomarkers. Results Neutrophils and neutrophil/lymphocyte ratio (NLR) were higher in the critical group, while lymphocytes were lower in the severe and critical groups compared to the mild group. The CRP, ferritin, and D-dimer values were more elevated in severe and critical cases than in mild COVID-19 cases. The levels of malondialdehyde (MDA), nitric oxide (NO), and copper were elevated, while the superoxide dismutase (SOD) activity level and total antioxidant capacity (TAC) level were lower. However, vitamin C, glutathione peroxidase (GPx), and catalase activity levels were not changed in the COVID-19 groups compared to the HCs. NO and ferritin were predictors of ICU hospitalization; D-dimer, MDA, and NLR were predictors of mortality. NO, and NLR were predictors of SpO 2 depression. Moreover, NO, and copper have both good diagnostic values, their cutoffs were 39.01 and 11.93, respectively. Conclusion There is an association between immune dysregulation and oxidative imbalance. The biomarkers, that could be considered as predictors for the severity and mortality of COVID-19, are the NLR, NO, ferritin, and D-dimer. The age equal to and older than 50 has a poor prognosis in the Kurdish population.

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Section: Discussionsupporting

confidence: 92%

Hematological, Inflammatory, Coagulation, and Oxidative/Antioxidant Biomarkers as Predictors for Severity and Mortality in COVID-19: A Prospective Cohort-Study

Smail¹,

Babaei²,

Amin³

2023

IJGM

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“…Strong correlations between obesity in adolescents and elevated ferritin levels were also described [ 24 ]. Interestingly, in the course of COVID-19, high ferritin levels correlated with a more frequent occurrence of cytokine storm in patients [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Iron Parameters among Men Performing Regular Physical Activity—A Preliminary Study

Zamelska

Rzepka

Olszewska−Słonina

et al. 2023

Life

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Iron deficiency anemia is one of the most common issues in clinical practice. It can be caused by intense physical activity, among other things. The aim of the study was to assess serum iron parameters in a group of men who engage in regular physical activity. The study group was composed of 20 men who regularly perform strength or endurance sports, whereas the control group consisted of 20 men without any sports activity. The red blood cell (RBC) parameters, platelet count (PLT), and white blood cell (WBC) count in venous blood samples were assessed with an automated hematology analyzer. The serum concentration of ferritin was determined through an immunology assay. There were no statistically significant differences between groups comparing RBC parameters and WBC. However, statistical analysis showed dissimilarity in PLT count and serum ferritin concentration comparing control and study groups (p < 0.05). It was shown that lower serum ferritin concentration concerns men with regular physical activity, whereas other blood parameters were not affected in this group.

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“…Serum ferritin level is raised in infectious and inflammatory diseases (Kernan & Carcillo, 2017). Among the inflammatory biomarkers, serum ferritin has the ability to define the disease course of COVID‐19 and predict the need for ICU admission and mortality (Kaushal et al, 2022; Shakaroun et al, 2022). Though our study observed a higher ferritin level in non‐survivor patients, it did not prove it as a significant risk factor of ICU admission or mortality when adjusted for other factors.…”

Section: Discussionmentioning

confidence: 99%

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

et al. 2022

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Aim This study aimed to identify the predictors of mortality and ICU requirements in hospitalized COVID‐19 Patients with Diabetes. Design Cross‐sectional study. Methods It was a retrospective study of patients hospitalized with COVID‐19 infection from October 2020–February 2021 in four hospitals in Sylhet, Bangladesh. Logistic regression analysis was applied to explore the predictors of ICU requirement and in‐hospital mortality. Results In the whole cohort (n = 500), 11% of patients died and 24% of patients required intensive care unit (ICU) support. Non‐survivors had significantly higher prevalence of lymphopenia, thrombocytopenia and leukocytosis. Significant predictors of in‐hospital mortality were older age, neutrophil count, platelet count and admission peripheral capillary oxygen saturation (SpO2). Older age, ischemic heart disease, WBC count, D‐dimer and admission SpO2 were identified as significant predictors for ICU requirement. Patient or Public Contribution No.

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Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia

Cited by 20 publications

References 33 publications

Hematological, Inflammatory, Coagulation, and Oxidative/Antioxidant Biomarkers as Predictors for Severity and Mortality in COVID-19: A Prospective Cohort-Study

Hematological, Inflammatory, Coagulation, and Oxidative/Antioxidant Biomarkers as Predictors for Severity and Mortality in COVID-19: A Prospective Cohort-Study

Evaluation of Serum Iron Parameters among Men Performing Regular Physical Activity—A Preliminary Study

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

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