Serum ferritin in relation to the course of Hodgkin's disease

M, Dorner; Abel, Ulrich; Fritze, Dieter; Manke, H. G.; Drings, P.

doi:10.1002/1097-0142(19831215)52:12<2308::aid-cncr2820521225>3.0.co;2-7

Cited by 37 publications

(7 citation statements)

References 31 publications

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“…In recent years, ferritin has been found to be synthesized and secreted by several entity malignant tumors, thus it may be considered an auxiliary diagnostic criterion for malignant tumors. Early literature suggests that the serum ferritin level in patients with leukemia, Hodgkin's disease, breast cancer, ovarian cancer and colon carcinoma markedly increases and is correlated with the degree of the disease (37,38). In our study, the specificity of ferritin in healthy volunteers was high with the false-positive ratio, reaching only 2.9% (Table III).…”

Section: Discussionmentioning

confidence: 99%

Combining multiple serum biomarkers in tumor diagnosis: A clinical assessment

Lü

Ren

et al. 2012

Molecular and Clinical Oncology

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Abstract. The present study aimed to assess the diagnostic/ prognostic value of various clinical tumor markers, including carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1), α-fetoprotein (AFP), carbohydrate antigen-125 (CA-125), carbohydrate antigen-19.9 (CA-19.9) and ferritin, individually or in combination. The electro-chemiluminescence immunization method was performed to detect the levels of seven tumor markers in 560 cancer patients and 103 healthy subjects for comparison. The serum levels of the seven markers measured in cancer patients were higher compared to healthy subjects (P<0.05 for AFP and P<0.001 for the remaining six markers). Different markers had different sensitivity towards different types of tumors. Combining more markers significantly increased the ratios of positive diagnosis in the tumors. The diagnostic sensitivities of combining seven markers were particularly high in digestive, urinary and skeletal tumors (82, 92 and 83%, respectively). Gynecological tumors have exhibited a constant yet relatively low positive diagnosis irrespective of the use of a single marker or combined markers. However, the increase in sensitivity when combining markers was accompanied by a decrease in specificity. Generally, combining more markers increased the tumor detection rates, while a combination of the seven markers provided the highest detection rate. Combined detection showed a particularly high sensitivity in detecting respiratory, digestive and urinary system tumors, with the lowest sensitivity observed in gynecological tumors. As a result, combining tumor markers may play an important role in early tumor detection/diagnosis while the loss of specificity can be tolerated.

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Section: Discussionmentioning

confidence: 99%

Combining multiple serum biomarkers in tumor diagnosis: A clinical assessment

Lü

Ren

et al. 2012

Molecular and Clinical Oncology

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“…5,6 Elevated serum ferritin also has been used as a harbinger of tissue masses including ovarian carcinoma, 7 Hodgkin disease, 8 renal cell carcinoma, 9 and melanoma, 10 and preterm deliveries. 11,12 Ferritin has been linked to insulin resistance [13][14][15] and, controversially, to atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Regulated secretion of glycosylated human ferritin from hepatocytes

Ghosh

Hevi

Chuck

2004

Blood

118

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Serum ferritin has been used widely in clinical medicine chiefly as an indicator of iron stores and inflammation. Circulating ferritin also can have paracrine effects. Despite the clinical significance of serum ferritin, its secretion remains an enigma. The consensus view is that serum ferritin arises from tissue ferritinsprincipally ferritin light-which can be glycosylated. Ferritin heavy and light chains are cytosolic proteins that form cages of 24 subunits to store intracellular iron. We show that ferritin light is secreted when its expression is increased in stable, transfected HepG2 cells or adenovirus-infected HepG2 cells. Export occurs through the classical secretory pathway and some chains are N-glycosylated. Ferritins do not need to form cages prior to secretion. Secretion is blocked specifically, effectively, and rapidly by a factor in serum. The timing of this inhibition of ferritin secretion suggests that normally cytosolic ferritin L is targeted to the secretory pathway during translation despite the absence of a conventional signal sequence. Thus, secretion of glycosylated and unglycosylated ferritin is a regulated and not a stochastic process. IntroductionSerum ferritin has wide clinical utility primarily as an indicator of intracellular iron stores 1-3 and as an acute-phase reactant useful for the diagnosis and follow-up of adult Still disease 4 and systemic lupus erythematosis. 5,6 Elevated serum ferritin also has been used as a harbinger of tissue masses including ovarian carcinoma, 7 Hodgkin disease, 8 renal cell carcinoma, 9 and melanoma, 10 and preterm deliveries. 11,12 Ferritin has been linked to insulin resistance [13][14][15] and, controversially, to atherosclerosis. 16 Thus, serum ferritin has been used for the diagnosis and follow-up of numerous disorders, although it is most strongly linked to intracellular iron status and adult Still disease.Despite the frequent use in clinical medicine of measurements of serum ferritin, most aspects of its secretion remain unknown. An understanding of the mechanism and regulation of the secretion of ferritin would inform the use of this commonly used clinical test. Moreover, the trafficking of normally cytosolic ferritins is relevant to the physiology of iron homeostasis and the pathophysiology of many disorders in which intracellular ferritin could play a role. [17][18][19][20] There are 2 forms of ferritin that function together to store iron in cells. 2 In humans, ferritin light (L) has a molecular mass of 19 kDa and consists of 175 amino acids. Human ferritin L is 53% identical to ferritin heavy (H), which contains 183 amino acids and is 21 kDa. 21 Unlike ferritin L, ferritin H contains a ferroxidase site. Cages that store iron atoms are formed from 24 ferritin monomers in varying ratios of H/L. [21][22][23] Both ferritin H and L subunits are necessary for efficient iron storage; although ferritin L lacks a ferroxidase site, the protein nucleates iron mineralization. 21,24 Ferritin is secreted from liver 25,26 and lymphoid cells. 27 Some studies...

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“…Serum ferritin levels have been reported to be elevated in HL patients, in particular in advanced stages and during disease progression [16,17]. Moreover, it has been proposed that the release of IL-6 stimulates the overproduction of hepcidin in the liver, which correlates with the iron restriction and contributes to anemia in HL [18].…”

Section: Discussionmentioning

confidence: 99%

On the prediction of Hodgkin lymphoma treatment response

et al. 2015

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-Martínez, jlfm@uniovi.es, 0034 985 103 199. AbstractPurpose: The cure rate in Hodgkin Lymphoma is high, but the response along the treatment is still unpredictable and is highly variable among patients. Detecting those patients that do not respond to the treatment at early stages could bring improvements in their treatment. This research tries to identify the main biological prognostic variables currently gathered at diagnosis, and designing a simple machine learning methodology to help physicians improving the treatment response assessment. Methods: We carried out a retrospective analysis of the response to treatment for a cohort of 263 Caucasians who were diagnosed with Hodgkin Lymphoma in Asturias (Spain). For that purpose, we used a list of 35 clinical and biological variables that are currently measured at diagnosis, before any treatment begins. To establish the list of most discriminatory prognostic variables for the treatment response we designed a machine learning approach based on two different feature selection methods (Fisher's ratio and Maximum Percentile Distance) and recursive feature elimination using a nearest-neighbor classifier (k-NN). The weights of the k-NN classifier are optimized using different terms of the confusion matrix (true and false positive rates) in order to minimize risk in the decisions. Results and conclusions: We found that the optimum strategy to predict treatment response in Hodgkin lymphoma consists in solving two

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Serum ferritin in relation to the course of Hodgkin's disease

Cited by 37 publications

References 31 publications

Combining multiple serum biomarkers in tumor diagnosis: A clinical assessment

Combining multiple serum biomarkers in tumor diagnosis: A clinical assessment

Regulated secretion of glycosylated human ferritin from hepatocytes

On the prediction of Hodgkin lymphoma treatment response

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