Serum fetuin A concentration is elevated in children with non-alcoholic fatty liver disease

Lebensztejn, Dariusz Marek; Białokoz‐Kalinowska, Irena; Kłusek-Oksiuta, Monika; Tarasów, Eugeniusz; Wojtkowska, Małgorzata; Kaczmarski, Maciej

doi:10.1016/j.advms.2013.08.003

Cited by 27 publications

(24 citation statements)

References 26 publications

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“…Reinehr and Roth showed that obese children with NAFLD demonstrated higher fetuin-A levels than obese children without liver disease and healthy controls 14 . Similar results were obtained by Lebensztejn et al in the larger group of children 37 . In longitudinal analyses, under weight loss due to short-term diet or exercise, improvement in NAFLD, measured by a decrease in liver fat, was accompanied by a reduction of fetuin-A concentration 3,5,24 .…”

Section: Fetuin-a As a Marker Of Liver Functionsupporting

confidence: 91%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Dabrowska

Tarach

Wojtysiak-Duma

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Section: Fetuin-a As a Marker Of Liver Functionsupporting

confidence: 91%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Dabrowska

Tarach

Wojtysiak-Duma

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Previous pediatric studies have determined fetuin A levels in healthy children [39, 40] as well as in obese children with and without T2D and NAFLD [2, 4, 13], and only three smaller studies have investigated fetuin A in children with T1D, with partially conflicting results [41-43]. …”

Section: Introductionmentioning

confidence: 99%

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

et al. 2017

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Background and Aim: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. Methods: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Patienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D. Fetuin A levels were further compared between adolescent T1D and T2D patients. Results: Serum fetuin A levels in T1D patients (mean 0.267 ± 0.043 g/L) did not correlate with age, diabetes duration, gender, body mass index (BMI), glycated hemoglobin, serum lipid levels, blood pressure, celiac or thyroid disease, nephropathy, or retinopathy. An association of fetuin A levels with insulin requirements was only evident within the subgroup of overweight T1D patients (r_s = 0.439, p = 0.028, n = 25, BMI >90th percentile), disappearing after adjustment for multiple testing. Adolescent T1D patients showed distinctly lower fetuin A levels than patients with T2D (p ≤ 0.001). Conclusion: Overall, we did not observe a clinically relevant association of fetuin A levels with surrogate parameters for insulin sensitivity in our juvenile T1D cohort. A correlation with insulin requirements was detectable in overweight patients only. We hypothesize that multiple factors, such as obesity, puberty, inadequate metabolic control, and hepatic steatosis, have to add up before a clinically relevant effect of fetuin A on insulin sensitivity becomes evident.

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“…Проводячи аналіз отриманих результатів, слід зазначити, що результати більшості досліджень свідчать про підвищення рівню сироваткового фет-A при НАЖХП, як у дорослих, так і у дітей [5,7,18]. Така тенденція спостерігався у дослідженнях Haukeland J.W., 2012 та Lebensztejn D.M., 2014.…”

Section: оцінка показників фетуїну-а у пацієнтів з коморбідностю неалunclassified

“…Було виявлено достовірне підвищення рівня фет-A. Важливим фактом є те, що у цих роботах досліджувалися пацієнти з ОЖ та іншими компонентами МС та переважна більшість з них мали підвищений рівень АЛТ [18]. У нашому дослідженні зв'язку між фет-А та АЛТ виявлено не було, але спостерігався зв'язок з СК-18 у групі коморбідності з ГХ.…”

Section: оцінка показників фетуїну-а у пацієнтів з коморбідностю неалunclassified

Assessment Of Fetuin-A In Patients With Comorbidity Of Non-Alcoholic Fatty Liver Disease And Arterial Hypertension

Prosolenko¹

2019

Shidnoevr. z. vnutr. simejnoi med.

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Serum fetuin A concentration is elevated in children with non-alcoholic fatty liver disease

Cited by 27 publications

References 26 publications

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

Assessment Of Fetuin-A In Patients With Comorbidity Of Non-Alcoholic Fatty Liver Disease And Arterial Hypertension

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