“…Previous studies have shown differences in circulating levels of endocrine FGFs (13,14) and fetuin-A (15) in PCOS women. FsGF21 and fetuin-A were reported to be elevated and FGF19 was found to be lower in PCOS women compared to healthy controls (13)(14)(15). Acute intralipid administration elevates circulating free fatty acid (FFA) and triglycerides, decreases peripheral glucose Abbreviations: PCOS, Polycystic ovary syndrome; T2D, Type 2 diabetes; IR, insulin resistance; IS, Insulin sensitivity; Endocrine FGF, FGF19, FGF21, and FGF23; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TCH, total cholesterol; HDL, high density lipoprotein; LDL, low density lipoprotein; TG, triglycerides; HbA1c, glycated hemoglobin; ALT, alanine aminotransferase; HIEC, hyperinsulinemic-euglycemic clamp; FGF, fibroblast growth factor; NAFLD, non-alcoholic fatty liver disease; HOMA-IR, homeostatic model assessment of insulin resistance; NEFA, non-esterified fatty acids; FSH, follicle-stimulating hormone; SHGB, sex hormone binding globulin; FAI, free androgen index.…”