Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

Abstract

Background. Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis. Method. Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model. Results. Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD = 1.36, 95%CI: 0.37–2.36, P = 0.007). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD = 1.73, 95%CI: 0.20–3.26, P = 0.026), but not in Asians (SMD = 1.04, 95%CI: −0.33–2.40, P = 0.138). Conclusion. The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.

Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions

“…Furthermore, decreased serum fetuin-A and albumin levels are associated with the development of coronary artery disease and heart valve calcification505152535455565758. Therefore, the risk factors of atherosclerosis and heart valve calcification are identical to those promoting the formation of CPB in the human blood.…”

Association between serum fetuin-A level and erectile function

“…For example, decreased concentrations may directly limit cardiac functions by promoting cardiac fibrosis and calcification, resulting in CVD progression (Lim et al ., ). Low levels were a valid predictor of CVD in previous prospective studies (Kadoglou et al ., ; Sun et al ., ) and have been linked to CVDs such as coronary artery disease, myocardial infarction, acute coronary syndrome and ST segment elevation myocardial infarction (Bilgir et al ., ; Sun et al ., ).…”

Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 2. Fetuin-A – A Marker of Insulin Resistance and Related Chronic Diseases

“…Several systematic reviews and metaanalyses evaluated the relationship between fetuin-A levels and the risk of CVDs. They provided contradictory results: the association with CVD risk in various prospective studies was found as a negative correlation (decreased serum fetuin-A level correlated with the development of CVDs) [53], as re ecting the progression of CVDs [54], or as inconsistent [55].…”

“…Higher fetuin-A circulation level in healthy diabetic and non-diabetic subjects without vascular pathology, correlated with CVD risks. However, a contradictory relationship was demonstrated in patients with established vascular disease [53]. It was assumed that in early CVD stages fetuin-A aggravates disease development due to induced insulin resistance and dyslipidemia.…”