Serum FGF-21 Levels in Type 2 Diabetic Patients

Xingbo, Cheng; Zhu, Bei; Jiang, Fusong; Fan, Hui

doi:10.3109/07435800.2011.558550

Cited by 65 publications

(55 citation statements)

References 25 publications

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“…In this study we were also interested in assessing the association of FGF21 with GDM, since FGF21 was previously found to significantly correlate with markers of insulin resistance and dyslipidemia [32] and to play a role in the pathogenesis of T2DM [33]. Our data indicated significantly higher unadjusted serum FGF21 levels in GDM women compared to the healthy pregnant controls.…”

Section: Enzyme-linked Immunosorbent Assay (Elisa)supporting

confidence: 46%

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

Seto-Young¹,

Avtanski²,

Kim³

et al. 2017

Clin Obstet Gynecol Reprod Med

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Background: Although Asians are generally characterized by lower body mass index (BMI) compared to Caucasians, the prevalence of gestational diabetes mellitus (GDM) among Asian women is higher. Our previous studies found that, like the Caucasians, pregnant Chinese women show difference between GDM and non-GDM in the levels of total adiponectin. However, there is no difference in other inflammatory markers such as CRP, TNFα, IL-6 or MCP-1. The aim of the present study was to assess the IGF-I, IGFBP-1, and FGF21 levels in Chinese-American women with and without GDM.

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Section: Enzyme-linked Immunosorbent Assay (Elisa)supporting

confidence: 46%

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

Seto-Young¹,

Avtanski²,

Kim³

et al. 2017

Clin Obstet Gynecol Reprod Med

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“…In this regard, circulating FGF21 concentrations have been found elevated in insulin-resistant states, such as impaired glucose tolerance and type 2 diabetes (DM2) (45,48,49,50,51,60) but decreased in type 1 diabetes and latent autoimmune diabetes in adults (61). FGF21 was also an independent predictor of DM2 in humans and its elevation is independent of the DM2 duration (62). Lastly, FGF21 seems to be also independently associated with markers of insulin resistance and an adverse lipid profile in polycystic ovary syndrome (63) and gestational diabetes (64).…”

Section: Fgf21 Insulin Resistance and Type 2 Diabetesmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21

Iglesias

Selgas

Romero

et al. 2012

European Journal of Endocrinology

101

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Fibroblast growth factor 21 (FGF21), a 181 amino acid circulating protein, is a member of the FGF superfamily, with relevant metabolic actions. It acts through the interaction with specific FGF receptors and a cofactor called β-Klotho, whose expression is predominantly detected in metabolically active organs. FGF21 stimulates glucose uptake in adipocytes via the induction of glucose transporter-1. This action is additive and independent of insulin. β-Cell function and survival are preserved, and glucagon secretion is reduced by this protein, thus decreasing hepatic glucose production and improving insulin sensitivity. Lipid profile has been shown to be improved by FGF21 in several animal models. FGF21 increases energy expenditure in rodents and induces weight loss in diabetic nonhuman primates. It also exerts favorable effects on hepatic steatosis and reduces tissue lipid content in rodents. Adaptive metabolic responses to fasting, including stimulation of ketogenesis and fatty acid oxidation, seem to be partially mediated by FGF21. In humans, serum FGF21 concentrations have been found elevated in insulin-resistant states, such as impaired glucose tolerance and type 2 diabetes. FGF21 levels are correlated with hepatic insulin resistance index, fasting blood glucose, HbA1c, and blood glucose after an oral glucose tolerance test. A relationship between FGF21 levels and long-term diabetic complications, such as nephropathy and carotid atheromatosis, has been reported. FGF21 levels decreased in diabetic patients after starting therapy with insulin or oral agents. Increased FGF21 serum levels have also been found to be associated with obesity. In children, it is correlated with BMI and leptin levels, whereas in adults, FGF21 levels are mainly related to several components of the metabolic syndrome. Serum FGF21 levels have been found to be elevated in patients with ischemic heart disease. In patients with renal disease, FGF21 levels exhibited a progressive increase as renal function deteriorates. Circulating FGF21 levels seem to be related to insulin resistance and inflammation in dialysis patients. In summary, FGF21 is a recently identified hormone with antihyperglycemic, antihyperlipidemic, and thermogenic properties. Direct or indirect potentiation of its effects might be a potential therapeutic target in insulin-resistant states.

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“…Serum levels of FGF21 are significantly higher in type 2 diabetic patients than in healthy controls [113]. Izumiya et al have described FGF21 as an Akt-regulated myokine based on their findings of an insulin-mediated increase of FGF21 protein level and secretion in C2C12 myotubes, and a phosphoinositide 3-kinase inhibitormediated prevention of these effects [114].…”

Section: Key Facts: Myokines As Therapeutic Targetsmentioning

confidence: 99%

Myokines in insulin resistance and type 2 diabetes

et al. 2014

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Skeletal muscle represents the largest organ of the body in non-obese individuals and is now considered to be an active endocrine organ releasing a host of so-called myokines. These myokines are part of a complex network that mediates communication between muscle, the liver, adipose tissue, the brain and other organs. Recent data suggest that myokines regulated by muscle contraction may play a key role in mediating the health-promoting effects of regular physical activity. Although hundreds of myokines have recently been described in proteomic studies, we currently have a rather limited knowledge of the specific role these myokines play in the prevention of insulin resistance, inflammation and associated metabolic dysfunction. Several myokines are known to have both local and endocrine functions, but in many cases the contribution of physical activity to the systemic level of these molecules remains as yet unexplored. Very recently, novel myokines such as irisin, which is thought to induce a white to brown shift in adipocytes, have gained considerable interest as potential therapeutic targets. In this review, we summarise the most recent findings on the role of myokines in the regulation of substrate metabolism and insulin sensitivity. We further explore the role of myokines in the regulation of inflammation and provide a critical assessment of irisin and other myokines regarding their potential as therapeutic targets.

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Serum FGF-21 Levels in Type 2 Diabetic Patients

Abstract: Serum FGF-21 levels were significantly increased in patients with T2DM. They may play a role in the pathogenesis of T2DM.

Cited by 65 publications

References 25 publications

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21

Myokines in insulin resistance and type 2 diabetes

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