Serum fibrinogen level in type 2 diabetes mellitus patients

Dhawale, Sanjay; Jayant, Satyam Singh; Gupta, Anil Kumar

doi:10.18203/2349-3933.ijam20160194

Cited by 14 publications

(21 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, HbA1c was the stronger predictor of serum fibrinogen than BMI. [15][16][17] In the present study serum fibrinogen did not show significant correlation with age (P-value>0.05). The studies conducted by Jain et al, Bembde, Saini et al and Bruno et al reported that serum fibrinogen had a significant correlation with age.…”

Section: Resultscontrasting

confidence: 63%

“…These findings are similar to other studies. [16][17][18][19][20]23 In the present study correlation between serum fibrinogen was 0.11, 0.20, -0.11, 0.11, 0.59, and 0.45 with TC, LDL cholesterol, HDL cholesterol, TG, HbA1c, and BMI respectively. Jain et al, reported fibrinogen levels were associated with BMI (r = 0.90), TG (r = 0.94), TC (r = 0.99), and HbA1c (r = 0.99) in DM patients in a significant manner.…”

Section: Resultssupporting

confidence: 52%

“…Similar findings were reported by other studies. 10,16,18,19 In the present research distribution of mean serum fibrinogen did not differ significantly between hypertensive and non-hypertensive cases studied (P-value>0.05). Similar findings were reported by Jain et al, Bembde and Saini et al 10,18,19 reported that fibrinogen levels were associated with hypertension (p<0.01).…”

Section: Resultscontrasting

confidence: 44%

See 2 more Smart Citations

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Topiwala¹,

Bahulikar²,

Beke³

et al. 2019

Int J Adv Med

View full text Add to dashboard Cite

Background: Poor glycemic control has been reported to be associated with increased vascular complications in diabetes mellitus (DM) patients. High fibrinogen level has been described as an independent risk factor for cardiovascular diseases. High fibrinogen has been suggested to be involved in the excess rate of cardiovascular diseases in patients with type 2 DM. The present study was undertaken to find correlation between glycemic control and plasma fibrinogen level in patients with type 2 DM.Methods: Three hundred ten patients aged ≥30 years of either sex were included in this cross sectional study. Estimation of glycated haemoglobin (HbA1c), serum fibrinogen, serum total cholesterol (TC), serum triglycerides (TG), serum high density lipoprotein (HDL) cholesterol, and serum low density lipoprotein (LDL) cholesterol was done. Categorical and continuous variables were tested using Chi-Square test/Fisher’s exact test and unpaired ‘t’ test respectively. Pearson’s correlation was used to study correlation between serum fibrinogen levels and HbA1c, Body mass index (BMI), TC, LDL cholesterol, HDL cholesterol, and TG.Results: Mean serum fibrinogen levels were significantly higher in DM patients whose HbA1c, LDL cholesterol and TG levels were higher. Correlation between serum fibrinogen was 0.59, and 0.45 with HbA1c, and BMI respectively. Multivariate step-wise regression analysis showed higher HbA1c and higher BMI were the independent and significant predictors of higher serum fibrinogen levels. HbA1c was the stronger predictor of serum fibrinogen than BMI.Conclusions: Fibrinogen levels were independently associated with HbA1c value in patients with type 2 DM.

show abstract

Section: Resultscontrasting

confidence: 63%

Section: Resultssupporting

confidence: 52%

Section: Resultscontrasting

confidence: 44%

See 1 more Smart Citation

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Topiwala¹,

Bahulikar²,

Beke³

et al. 2019

Int J Adv Med

View full text Add to dashboard Cite

show abstract

“…Similarly Malenica M et al [29] and Agrawal A et al [30] showed positive correlation of IL-6 with FBS and HbA1c. However Dhawale S et al [31] could not document such significant relationship between fibrinogen, FBS and HbA1c. With respect to uric acid, Rabari K et al [32] documented significant linear correlation with both glycemic parameters while Whitehead P et al [33] and Hidayat MF et al [34] could document such relation with HbA1c only.…”

Section: Discussionmentioning

confidence: 84%

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

View full text Add to dashboard Cite

Background: Subclinical inflammation characterized by elevated inflammatory markers is found in diabetic patients. Inflammation, an important cardiovascular risk factor, is elevated in diabetics with poor glycemic control than those with good control. Aim: To study the effect of glycemic status on inflammatory markers in pre-diabetes and diabetes. Methods: This study included 300 subjects divided into 3 groups; Control: 100, Pre-diabetes: 100 patients and Diabetes: 100 patients. Basic details of all the participants like age and gender were recorded and laboratory investigations like fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), IL-6, CRP, fibrinogen, uric acid and adiponectin were conducted. Results: Compared to controls, the levels FBS, HbA1c, IL-6, CRP, fibrinogen and uric acid were elevated and adiponectin was decreased in pre-diabetes and diabetes. The inflammatory parameters (IL-6, CRP, fibrinogen, uric acid and adiponectin) were significantly correlated with glycemic parameters (FBS, HbA1c) in diabetes, i.e. r=0.28, r=0.55, r=0.2, r=0.48 and r=-0.4 respectively in case of FBS and r=-0.39, r=0.48, r=0.21, r=0.33 and r=-0.53 respectively for HbA1c. Similarly, in pre-diabetes, FBS correlated significantly with adiponectin (r=-0.19), fibrinogen (r=0.29) and uric acid (r=0.18) while that with HbA1c was significant with adiponectin (r=-0.31), IL-6 (r=0.25), CRP (r=0.21) and fibrinogen (r=0.3). Conclusion:The strong correlations observed between glycemic control parameters and inflammation parameters in prediabetes and diabetes suggested the crucial involvement of inflammation in the diabetes development. So better control of glycemia can cause significant reduction in inflammation and arrest the health burden.

show abstract

“…Diabetes mellitus is the most common metabolic disorder characterized by metabolic abnormalities and long term complications. The chronic complications of diabetes mellitus affect many organ systems and are responsible for the majority of morbidity and mortality associated with the disease [1]. The worldwide prevalence of diabetes mellitus has been increased dramatically over the past two decades and the prevalence of noninsulin dependent diabetes mellitus (NIDDM) is expected to rise more rapidly in future because of increasing obesity and reduced activity levels.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Glycemic Status with Plasma Fibrinogen Level in Insulin Dependent as Well as Noninsulin Dependent Diabetic Patients

Mohiuddin¹

2018

JED

View full text Add to dashboard Cite

Aims and objective: Fibrinogen is an indicator of an inflammatory vascular changes and endothelial dysfunction. It has been identified as an independent risk factor for cardiovascular disease and it is closely associated with traditional cardiovascular risk factors. Diabetic patients have higher cardiovascular morbidity than non-diabetic individuals. Patients with diabetes mellitus have 2 to 4 times increased risk for cardiovascular disease than non-diabetic patients. Several studies have shown that haemostatic factor especially hyperfibrinogenemia is implicated as a source of atherosclerotic changes and its complications. Fibrinogen which is an acute phase protein plays a key role in the pathogenesis of atherosclerosis and complication of atherothombosis disease. Pathogenesis of noninsulin dependent diabetes mellitus (NIDDM), widely known as type 2 diabetes is observed to closely relate with acute phase response which is predominately cytokine mediated. The role of inflammation in insulin dependent type 1 diabetes (IDDM) is still contradictory. By estimating circulating fibrinogen in NIDDM and IDDM patients, we tried to establish this hypothesis. Methods: Freshly diagnosed twelve IDDM cases, twenty-five NIDDM cases and twenty-five NIDDM cases under oral hypoglycemic agent for at least 5 years were selected for this study and were estimated their glycemic status and the level of fibrinogen. Thirty normal controls were also selected. Results: Freshly diagnosed IDDM and NIDDM cases showed significantly higher levels of the fibrinogen in compare to control. Plasma fibrinogen was higher and had positive correlation with increased duration of diabetes. NIDDM cases had slightly elevated values of fibrinogen in compared to the IDDM cases. There are no significant change of fibrinogen level is found in NIDDM cases after treating by oral hypoglycemic drugs for at least 5years in compare of freshly diagnosed NIDDM cases. Conclusion: By evaluating the plasma level of fibrinogen in different categories it can be postulated that NIDDM patients had a higher plasma fibrinogen level in compare to control. Fibrinogen level was significantly correlated with glycemic control. This line of pathological basis should be further explored for diagnosis, management and follow up.

show abstract

Serum fibrinogen level in type 2 diabetes mellitus patients

Cited by 14 publications

References 11 publications

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Correlation of Glycemic Status with Plasma Fibrinogen Level in Insulin Dependent as Well as Noninsulin Dependent Diabetic Patients

Contact Info

Product

Resources

About