Serum fibronectin content in the patients suffering from type 1 diabetes mellitus with microangiopathies since the childhood and in the subjects presenting with obesity

Abstract

Micro- and macroangiopathies are the main causes of disability and mortality among the patients suffering from diabetes mellitus. Endothelial dysfunction is the early and important condition preceding the development of diabetic angiopathies. The serum fibronectin content may be one of the markers of endothelial dysfunction. We have documented the enhanced serum fibronectin content in the patients suffering from type 1 diabetes mellitus with concomitant microangiopathies and in the subjects presenting with obesity. The rise in the serum fibronectin level correlated with the body mass index, parameters of carbohydrate and lipid metabolism. Alteration of these parameters discovered in the present study may be used as the markers of endothelial dysfunction associated with the above pathological conditions.