Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study

Voutilainen, Sari; Virtanen, Jyrki K.; Rissanen, Tiina H.; Alfthan, Georg; Laukkanen, Jari; Nyyssönen, Kristiina; Mursu, Jaakko; Valkonen, Veli-Pekka; Tuomainen, Tomi‐Pekka; Kaplan, George A.; Salonen, Jukka T.

doi:10.1093/ajcn/80.2.317

Cited by 66 publications

(59 citation statements)

References 33 publications

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“…The strength of association of Hcy with risk of CVD may be weaker than had previously been believed (2006). Examining the studies included in this review, only 10 studies reported on associations of folate, vitamin B12 and Hcy with CVDs (Verhoef et al, 1997;Girelli et al, 1998Girelli et al, , 2003Christensen et al, 1999;Chambers et al, 2000;de Bree et al, 2003b;Nurk et al, 2004;Voutilainen et al, 2004;Vrentzos et al, 2004;Durga et al, 2005;Van Guelpen et al, 2005). Homocysteine status was positively associated with several outcome measures of CVD in 8 out of 10 studies.…”

Section: Extrapolationsmentioning

confidence: 99%

“…Much attention has been given to B-vitamins, in particular to folate and vitamin B12, because of their potential influence on cardiovascular diseases (CVD) (Folsom et al, 1998;Rimm et al, 1998;Eikelboom et al, 1999;Chambers et al, 2001;Schnyder et al, 2001;Voutilainen et al, 2001Voutilainen et al, , 2004, cognitive function Malouf et al, 2003;Tucker et al, 2005) and bone health (McLean et al, 2004;van Meurs et al, 2004;Sato et al, 2005). The link between these B-vitamins and CVD is suggested to be, partly, explained via homocysteine (Hcy), though conclusive trial evidence of lowering Hcy is still required to have sufficient power to detect plausible differences in risk at convincing levels of significance (Anonymous, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

et al. 2007

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Background/Objectives: Folate and vitamin B12 have been suggested to play a role in chronic diseases like cardiovascular diseases. The objectives are to give an overview of the actual intake and status of folate and vitamin B12 in general populations in Europe, and to evaluate these in view of the current vitamin recommendations and the homocysteine concentration. Methods: Searches in Medline with 'folic acid', 'folate' and 'vitamin B12', 'B12' or 'cobalamin' as key words were combined with the names of the European countries. Populations between 18 and 65 years were included. Results: Sixty-three articles reporting on studies from 15 European countries were selected. Low folate intakes were observed in Norway, Sweden, Denmark and the Netherlands. Low intakes of vitamin B12 were not common and only seen in one small Greek study. In the countries with a low intake of folate, the recommended levels were generally not achieved, which was also reflected in the folate status. Vitamin B12 intake was not strongly associated with the vitamin B12 status, which can explain why in the Netherlands and Germany the vitamin B12 status was inadequate, despite sufficient intake levels. In countries with a low folate intake in particular, the Hcy concentration was higher than ideal. Conclusions: Populations from the Nordic countries, the Netherlands, Germany and Greece may need to improve their intakes of folic acid, B12 or both to either meet the recommendations or to optimize their statuses. This could be achieved via a foodbased approach, food fortification or supplements.

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Section: Extrapolationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

et al. 2007

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“…Using data from the Framingham Heart Study, Friso et al (17 ) demonstrated a strong relationship between impaired vitamin B 6 status and a proinflammatory state, as indicated by CRP concentrations independent of homocysteine (Hcy) concentrations. These findings suggested that vitamin B 6 may be implicated in some antiinflammatory mechanism, perhaps acting as a cofactor.…”

Section: Hemostasis and Thrombosismentioning

confidence: 99%

Predictors of Vitamin B6 and Folate Concentrations in Older Persons: The InCHIANTI Study

et al. 2006

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Background: Low dietary intake and low serum concentrations of vitamin B 6 and/or folate are associated with increased risk of vascular events, possibly because of their association with inflammation, which plays a crucial role in the pathogenesis of cardiovascular diseases. Methods: Using data from 1320 participants in the population-based InCHIANTI study (586 men and 734 women; median age, 69 years; range, 21-102 years) for whom complete data on folate, vitamin B 6 , inflammatory markers, 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T sequence variant, and important covariates were available, we evaluated the association of inflammatory markers with circulating concentrations of vitamin B 6 and folate, independently of dietary vitamin intake, circulating vitamin concentrations, and MTHFR C677T sequence variant. Results: According to multiple linear regression analysis, C-reactive protein and interleukin-6 receptor were strongly and negatively associated with circulating vitamin B 6 but not with folate concentrations, independent of age, sex, serum creatinine, serum albumin, total energy intake, smoking history, dietary nutrient intake,

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“…However, there is evidence for folate alone influencing human vascular disease. High circulating folate is associated with reduced risk of primary coronary events and carotid intima-media thickness independently of total plasma homocysteine in several prospective human studies (Voutilainen et al 2000(Voutilainen et al , 2004Durga et al 2005). Moreover, supplemental folic acid positively influences vascular function in patients with, or at risk of, vascular disease (Mangoni et al 2005;Tawakol et al 2005;Till et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Low dietary folate is strongly associated with an increased risk of human vascular diseases including atherosclerosis and stroke (Voutilainen et al 2000(Voutilainen et al , 2004Durga et al 2005). This has been attributed primarily to suboptimal intracellular folate, together with low levels of vitamins B 12 and B 6 , inducing hyperhomocysteinemia (Splaver et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice

et al. 2014

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Low B vitamin status is linked with human vascular disease. We employed a proteomic and biochemical approach to determine whether nutritional folate deficiency and/or hyperhomocysteinemia altered metabolic processes linked with atherosclerosis in ApoE null mice. Animals were fed either a control fat (C; 4 % w/w lard) or a high-fat [HF; 21 % w/w lard and cholesterol (0/15 % w/w)] diet with different B vitamin compositions for 16 weeks. Aorta tissue was prepared and global protein expression, B vitamin, homocysteine and lipoprotein status measured. Changes in the expression of aorta proteins were detected in response to multiple B vitamin deficiency combined with a high-fat diet (P \ 0.05) and were strongly linked with lipoprotein concentrations measured directly in the aorta adventitia (P \ 0.001). Pathway analysis revealed treatment effects in the aorta-related primarily to cytoskeletal organisation, smooth muscle cell adhesion and invasiveness (e.g., fibrinogen, moesin, transgelin, vimentin). Combined B vitamin deficiency induced striking quantitative changes in the expression of aorta proteins in atherosclerotic ApoE null mice. Deregulated expression of these proteins is associated with human atherosclerosis. Cellular pathways altered by B vitamin status included cytoskeletal organisation, cell differentiation and migration, oxidative stress and chronic inflammation. These findings provide new insight into the molecular mechanisms through which B vitamin deficiency may accelerate atherosclerosis.

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Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study

Cited by 66 publications

References 33 publications

Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations

Predictors of Vitamin B6 and Folate Concentrations in Older Persons: The InCHIANTI Study

Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice

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