Serum Free Sialic Acid as a Marker of Alcohol Abuse

Chrostek, Lech; Cylwik, Bogdan; Korcz, Walenty; Krawiec, Agnieszka; Koput, Alicja; Supronowicz, Zbigniew; Szmitkowski, Maciej

doi:10.1111/j.1530-0277.2007.00392.x

Cited by 20 publications

(13 citation statements)

References 15 publications

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“…Common name Specificity Application As L-PHA is reactive with b(1,6) branched structures of trimannosyl core asparagine-linked glycans which are highly selective markers of the metastatic potential of tumor cells, this lectin is used in cancer diagnosis acid (FSA) were studied as potential markers of alcohol abuse [31]. Both TSA en FSA were significantly increased during alcohol abuse, but as markers, they have a low sensitivity (46%) and negative predictive value (27%).…”

Section: Lectinmentioning

confidence: 99%

Alteration of protein glycosylation in liver diseases

Blomme

Steenkiste

Callewaert

et al. 2009

Journal of Hepatology

201

173

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Section: Lectinmentioning

confidence: 99%

Alteration of protein glycosylation in liver diseases

Blomme

Steenkiste

Callewaert

et al. 2009

Journal of Hepatology

201

173

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“…Most of the glycoproteins found in serum are α-1 glycoproteins (orosomucoid), α-antitrypsin, fibrinogen, haptoglobulin, and transferrin [43,44]. Carbohydrates found in serum glycoproteins are hexose, hexosamine, fucose, and sialic acid [45].…”

Section: Naf Groupmentioning

confidence: 99%

“…Sialic acid is an acute phase protein derived from neuraminic acid which forms terminal sugar of carbohydrates taking part in the glycoprotein structure [17]. Sialic acids play a role in cell -cell recognition, protein targeting, protease resistance, conformational stabilization, adhesion, and intracellular signaling events in biological systems [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Fluoride Exposure on Serum Glycoprotein Pattern and Sialic Acid Level in Rabbits

Çiftçi

Çenesiz

Yarım

et al. 2009

Biol Trace Elem Res

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This study describes the effects of fluoride exposure on the protein profile, glycoprotein pattern, and total sialic acid concentration of serum in rabbits. For this aim; 20 healthy New Zealand rabbits were used. The rabbits were divided into two equal groups each with ten animals according to their weighing: control group and experimental group. The rabbits in control group were given drinking tap water containing 0.29 mg/l sodium fluoride and experimental group received the same tap water to which was added 40 mg/l sodium fluoride for 70 days. Blood samples were taken from each rabbit on day 70. Serum fluoride concentrations were measured by a fluoride-specific ion electrode in serum. The fluoride levels in the serum were found as 18.4 (±1.58) μg/L in control and 301.3 (±52.18) μg/L in fluoride exposed rabbits. The sialic acid levels were found as 69.2 (±0.32) mg/dL in control and 43.4 (±0.13) mg/dL in fluoride exposed group. The electrophoretic patterns of serum proteins, glycoproteins, and total sialic acid concentration were determined. Fifteen different protein fractions with molecular weights ranging from 22 to 249 kDa were displayed in the serum protein electrophoretic gel of both groups. The raw concentrations of the protein fractions decreased in fluoride exposed rabbits as compared with the control rabbits. The serum glycoprotein pattern revealed seven major protein bands from 47 to 167 kDa in experimental and control groups. The slight decrease of raw concentration of the protein bands in glycoprotein pattern of serum was observed in fluoride toxication comparing to control. The

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“…As chronic alcohol use prevents the glycosylation of many proteins (e.g., fibrinogen, complement proteins and transferrin), TSA significantly increases during alcohol abuse [31,32] and normalizes during alcohol withdrawal [30]. TSA is also elevated in saliva and urine in heavy alcohol drinkers [33].…”

Section: Nonprotein Alcohol Abuse Biomarkersmentioning

confidence: 99%

Protein biomarkers of alcohol abuse

Torrente

Freeman

Vrana³

2012

Expert Review of Proteomics

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Alcohol abuse can lead to a number of health and social issues. Our current inability to accurately assess long-term drinking behaviors is an important obstacle to its diagnosis and treatment. Biomarkers for chronic alcohol consumption have made a number of important advances but have yet to become highly accurate and as accepted as objective tests for other diseases. Thus, there is a crucial need for the development of more sensitive and specific markers of alcohol abuse. Recent advancements in proteomic technologies have greatly increased the potential for alcohol abuse biomarker discovery. Here, the authors review established and novel protein biomarkers for long-term alcohol consumption and the proteomic technologies that have been used in their study.

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Serum Free Sialic Acid as a Marker of Alcohol Abuse

Cited by 20 publications

References 15 publications

Alteration of protein glycosylation in liver diseases

Alteration of protein glycosylation in liver diseases

Effect of Fluoride Exposure on Serum Glycoprotein Pattern and Sialic Acid Level in Rabbits

Protein biomarkers of alcohol abuse

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