Serum Glucose Level and Hemoglobin Concentration in Third Trimester of Pregnancy

Abstract

Background : Pregnancy is a state of physiological adaptations to accommodate the needs of the developing fetus. Elevated blood glucose during pregnancy could lead to gestational diabetes and anemia could cause intercurrent infection. Objective: To assess the serum glucose level & hemoglobin concentration in third trimester of pregnancy in order to find out the risk of gestational diabetes and physiological anemia. Method: This cross-sectional study was carried out in the Department of Physiology Mymensingh Medical College, Mymensingh, between the period of July, 2013 to June,2014. One hundred pregnant women in their third trimester of pregnancy aged 18-35years were enrolled in study group and age matched 100 healthy non-pregnant women were control group. Random serum glucose was estimated by GOD-PAP method and hemoglobin concentration was measured by cyanmethemoglobin (CMG) method. Data were analyzed by student's un paired t test and chi square test. Result: Mean serum glucose level (6.76±1.72 mmol/L) was significantly higher and hemoglobin concentration (8.21±1.23 g/dl) was significantly lower in pregnant women than non-pregnant women. Increased frequency of high glucose (38%) and low H b(88%) was found in pregnant women in third trimester. Conclusion: This study concludes altered glucose metabolism may lead to gestational diabetes as well as physiological anemia may be exaggerated in third trimester of pregnancy.

Clinical and Prognostic Value of Vascular Wall Elasticity in Pregnant Women with Arterial Hypertension: A Review

“…Thus, according to Phan K, Schiller I, Dendukuri N et al (2021), it was shown that in pregnant women with preeclampsia, the PWV index increased from 14-17 weeks and at 22-25 weeks was 1.2 m/s higher compared to the value of this parameter in pregnant women without preeclampsia. The same study showed an increase in the augmentation index from 18-21 weeks in pregnant women with subsequent development of preeclampsia, whereas in women without preeclampsia, this indicator increased at 30-33 weeks of gestation [27].…”

“…It is noted that the feature of the daily blood pressure profile in pregnant women with hypertension is the predominance of the type of daily curve with an insufficient nighttime decrease in blood pressure-non-dipper (0 <NCBI < 10%), as well as with nighttime blood pressure exceeding daily values-night-picker (NCBI < 0) [21,22,24,25]. According to other data, hypertensive pregnant women are characterized by systolic hypertension in the morning and in emotional states, as well as the optimal degree of nocturnal blood pressure reduction (10-20%)the dipper type [26,27,28]. At the same time, 20-30% of normotensive women with a physiological course of pregnancy have a non-dipper profile, which may complicate the diagnosis of hypertension [29].…”

Serum Uric Acid and Plasma Glucose Levels in Normal Pregnancy

“…However, no change was observed in the level of fasting plasma glucose of non-pregnant controls compared with second-trimester pregnancies. Ekhator and Ebomoyi, Gaya et al, Church et al, Zannat et al, Sufrin et al, found a high level of serum glucose in most of the pregnant women in their third trimester [34][35][36][37][38]. The results of Ekhator and Ebomoyi in a population of normal pregnant Nigerian women showed that glucose concentration was significantly higher in pregnant women than the control group, and it was highest in the third trimester of pregnancy [34].…”

“…The results of a cross-sectional study by Zannat et al, in normal pregnant women showed that serum glucose levels increased significantly in the third trimester, while a non-significant value was found in first trimester [37]. In a study of normal pregnant women conducted by Sufrin et al, mean serum glucose level was found to be significantly higher in third-trimester pregnant women than non-pregnant women [38].…”