Serum haptoglobin type and liver cirrhosis

Abstract

Haptoglobin phenotypes were studied by a polyacrylamide gel electrophoresis on 200 blood donors and 105 patients with liver cirrhosis, of which 79% belonged to non-alcoholic etiology. Though no difference of haptoglobin types could be found between blood donors with positive and negative hepatitis B antigen, the cirrhois patients had an excess haptoglobin gene 1. The patients with haptoglobin gene 1 were associated with severe liver dysfunction. Since the family pedigrees of the patients with type 1--1 excluded individuals with type 2--2, the phenotypes seemed to be stable in the cirrhotic process. The possibility that the haptoglobin 2 gene offered resistence to the non-alcoholic cirrhosis was discussed.

Serum Haptoglobin Phenotypes and Duodenal Ulcer

“…The distribution of Hp genes and phenotypes varies considerably all over the world (Giblett 1969). On the other hand, a relationship seems to be possible between the Hpl gene and some diseases, i.e., leukemia (Peacock 1966) and liver cirrhosis (Hirayama et al 1975). In the international literature we have found only one record of the distribution of Hp phenotypes among patients of peptic ulcer (Wendt et al 1968).…”

Liver Cells and Serum Genetical Components

“…Ip phenotypes ]'n human sera of hepaLic pal.ients(Jdr.crensen & Hopfer, 1967; Marecek & Huenigova, ]970; Nandi et al, 1970;Hirayama et al, ]975).…”