Serum haptoglobin types and leukemia

Abstract

Haptoglobin types were determined on 211 patients with leukemia of the four most common types: acute lymphatic (ALL), chronic lymphatic (CLL), acute myeloid (AML), and chronic myeloid leukemia (CML). Frequency distributions of the three common Hp types in patients differed significantly from the control population. A significant increase in the relative incidence of Hp 1-1 was observed in patients with ALL, AML, and CML, but not with CLL. A similar trend was consistent in the data from previously published studies for the same three types of leukemia but not for CLL. Our results and the analysis of data from previous studies, suggest an association of Hp type with some leukemias, which is expressed in a consistent elevation of Hp 1-1 type among leukemia patients with ALL, AML, and CML.

Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population

“…Because the expression of BCR/ABL stimulates ROS production, which may contribute to increased DNA damage in CML cells (Sattler et al, 2000;Nowicki et al, 2004), the Hp polymorphism has been investigated in leukemias, and the Hp1-1 phenotype has been associated with increased risk (Nevo and Tatarsky, 1986;Mitchell et al, 1988;Campregher et al, 2004). Despite the small sample size and large confidence interval, results indicated increased CML risk for Hp1F-1S individuals of black skin color and decreased risk for the same group carrying the Hp1S-2 genotype.…”

“…Polymorphic variants of several genes, diet, environmental exposure to carcinogens and individual immune system's characteristics are potential factors that increase predisposition to leukemia (Bowen et al, 2003). Association studies have been performed to identify genetic variants associated with CML susceptibility, and among them are methylenetetrahydrofolate reductase (MTHFR) (Hur et al, 2006;Moon et al, 2007;Barbosa et al, 2008), glutathione S-transferases (GSTs) (Hishida et al, 2005;Souza et al, 2008), and haptoglobin (Hp) gene polymorphisms (Nevo and Tatarsky, 1986;Campregher et al, 2004).…”

“…It is known that the BCR/ABL expression stimulates ROS production in hematopoietic progenitor cells (Sattler et al, 2000) and studies have suggested that ROS may contribute to increased DNA damage in CML cells (Nowicki et al, 2004). Because the ability of Hp to block hemoglobin-induced oxidative stress and damage is phenotype dependent (Carter and Worwood, 2007), Hp polymorphism has been investigated in association with leukemia, and the Hp1-1 phenotype has been associated with CML, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) (Nevo and Tatarsky, 1986;Mitchell et al, 1988). However, the frequency distributions of Hp phenotypes and alleles vary among populations worldwide (Carter and Worwood, 2007), so it is important to run further association studies with CML in different ethnic groups to better evaluate these risks.…”

Under Increased Hydrogen Peroxide conditions, the Antioxidant Effects of Pequi Oil (Caryocar brasiliense Camb.) to Decrease DNA Damage in Runners are Influenced by Sex, Age and oxidative Stress-related Genetic Polymorphisms

“…[18,57] Hp polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases. [58] It has also been investigated with leukemia, and the Hp1-1 phenotype associated with CML, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). [58,59] Recently, Hp polymorphism has also been suggested as a determining factor in runners' performance.…”

“…[58] It has also been investigated with leukemia, and the Hp1-1 phenotype associated with CML, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). [58,59] Recently, Hp polymorphism has also been suggested as a determining factor in runners' performance. [44] In our previous studies, deviation from HWE was mainly due to higher than expected frequency of Hp1F-1F and 1S-1S contrasting with lower frequency of Hp1F-1S.…”