Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma

Cheng, Baoquan; Jia, Chong-Qi; Liu, C.-T.; Lü, Xiaofei; Zhong, Ning; Zhang, Z.-L.; Fan, W W; Li, Y.-Q.

doi:10.1016/j.dld.2007.11.024

Cited by 91 publications

(83 citation statements)

References 25 publications

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“…Our results showed that the expression of Survivin was upregulated in T-cell lymphoma compared to that in reactive lymphoid hyperplasia. Consistent with previous reports (Kuniyasu et al, 2002;Cheng et al, 2008;Chung et al, 2009), the expression of HMGB1 and Survivin was correlated with the aggressiveness and stage of tumors. Therefore, HMGB1 and Survivin may be involved in the development and progression of T-cell lymphoma and could be new targets for targeted molecular therapy.…”

Section: Discussionsupporting

confidence: 80%

“…It is expressed in tumor tissues of several cancers including liver cancer, breast cancer, colon cancer, and ovarian cancer, and plays critical roles in gene regulation and tumor immunology (Jube et al, 2012). It has been shown that HMGB1 can be secreted from cells and its level in serum is significantly upregulated in cancer patients compared to that in normal controls (Cheng et al, 2008). We found that HMGB1 was expressed in T-cell lymphoma as well as reactive lymphoid hyperplasia and normal lymphoid.…”

Section: Discussionmentioning

confidence: 71%

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Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Mao

Wang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 71%

Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Mao

Wang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Extracellular HMGB1 during HCV infection can trigger the interferon antiviral response through a TLR4-dependent pathway (61,63). HMGB1 serum levels are significantly higher in patients with chronic HBV than in normal healthy people and are closely related to the stage of inflammation and fibrosis in the liver ( Figure 4A) (64). In addition, HMGB1 plays an important role in the pathogenesis of liver failure in chronic HBV patients by downregulation of Foxp3 expression and inhibiting the immune activity of regulatory T cells (65).…”

Section: Hmgb1 and Viral Hepatitismentioning

confidence: 96%

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

Chen

Hou

Zhang

et al. 2013

Mol Med

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Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal protein that has location-specific biological functions: within the nucleus as a DNA chaperone, within the cytosol to sustain autophagy and outside the cell as a DAMP molecule. Recent research indicates that aberrant activation of HMGB1 signaling can promote the onset of inflammatory and autoimmune diseases, raising interest in the development of therapeutic strategies to control their function. The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review.

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“…Considered these results together, HMGB1 release through tumor cell death might contribute to the elevation of serum HMGB1 levels. On the other hand; it was well known that HMGB1 can be actively released from immune cells into the extra-cellular space or serum [19]. HMGB1 was known to be important in malignant cell transformation.…”

Section: Discussionmentioning

confidence: 99%

Serum high mobility group box protein 1 as a clinical marker for ovarian cancer

Tian

et al. 2014

neo

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The aim of the study was to evaluate the clinical value of serum high mobility group box chromosomal protein 1 (HMGB1) in ovarian cancer and analyze the correlation between HMGB1 and ovarian cancer clinicopathologic outcomes.A total of 105 patients with diagnosed epithelial ovarian cancer, 46 patients with ovarian benign disease and 33 healthy volunteers were enrolled from January 2011 through January 2013. Serum HMGB1 levels were analyzed by enzyme-linked immunosorbent assay.The mean value of serum HMGB1 levels in ovarian cancer patients (78.18±54.87ng/ml) was significantly higher than those in benign patients (33.98±9.97ng/ml) and healthy control (26.71±7.99ng/ml, p < 0.0001), respectively. The serum HMGB1 levels were 40.33±6.50ng/ml, 61.16±20.15ng/ml, 81.81±51.15ng/ml and 119.48±84.28ng/ml in patients with TNM stage I, II, III, and IV, respectively (p < 0.0001). There were 81 of the 105 ovarian cancer patients obtained complete remission, the serum HMGB1 levels before treatment(71.99±42.49ng/ml) were much higher than that at remission stage(42.10±15.48ng/ml) (p < 0.0001). During our investigating period, 28 ovarian cancer patients underwent recurrence, the serum HMGB1 levels were 75.54±39.50ng/ml in these recurrent ovarian cancer patients compared to 42.04±10.68ng/ml in non-recurrent ovarian cancer (p < 0.0001). None of the remission or recurrent patients came from benign ovarian tumor group.Our study suggests that HMGB1 may be a useful clinical marker for evaluating progression and predicting prognosis of ovarian carcinoma. Targeting HMGB1 production or release might have potential approaches for ovarian carcinoma treatment.

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Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma

Cited by 91 publications

References 25 publications

Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

Serum high mobility group box protein 1 as a clinical marker for ovarian cancer

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Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma

Cited by 91 publications

References 25 publications

Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Expression of HMGB1 and its Clinical Significance in T-cell Lymphoma

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

Serum high mobility group box protein 1 as a clinical marker for ovarian cancer

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Product

Resources

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Serum high mobility group box protein 1 as a clinical marker for ovarian cancer