Serum Homocysteine Concentration Is Significantly Associated with Inflammatory/Immune Factors

Abstract

Recent studies suggest that serum homocysteine (HCY) level is correlated to inflammatory/immune factors that influence the development and progression of many diseases, such as cardiovascular disease. However, the association between serum HCY level and inflammatory/immune factors in healthy populations has not been systematically investigated. This study was conducted based on the Fangchenggang Area Male Health and Examination Survey (FAMHES) project. After comprehensive baseline analysis, we could not find any significant association between HCY level and inflammatory/immune factors. However, in the next linear regression analysis, serum C4 [age-adjusted: Beta = -0.053, 95%CI = (-3.798, -0.050), P = 0.044; multivariate adjusted: Beta = -0.064, 95%CI = (-4.271, -0.378), P = 0.019] and C-reactive protein (CRP) concentration [unadjusted: Beta = 0.056, 95%CI = (0.037, 0.740), P = 0.030] were positively related with HCY. In further binary regression analysis, a significant correlation was confirmed for C4 and HCY [age-adjusted: OR = 0.572, 95%CI = (0.359, 0.911); multivariate adjusted: OR = 0.558, 95%CI = (0.344, 0.905)]. In order to discover more potential associations, multivariate logistic regression analysis was applied and suggested that HCY and C4 were significantly correlated [age-adjusted: OR = 0.703, 95%CI = (0.519, 0.951); multivariate adjusted: OR = 0.696, 95%CI = (0.509, 0.951)]. In addition, immunoglobulin M (IgM) may influence the HCY level to some extent [unadjusted: OR = 1.427, 95%CI = (1.052, 1.936); age-adjusted: OR = 1.446, 95%CI = (1.061, 1.970); multivariate adjusted: OR = 1.447, 95%CI = (1.062, 1.973)]. Combining our results with recent studies, we propose that C4, CRP, and IgM in serum are significantly associated with HCY concentration. Further studies are needed on the mechanism of the interaction, especially among cardiovascular disease subjects.

Opposite impact of Methylene tetrahydrofolate reductase C677T and Methylene tetrahydrofolate reductase A1298C gene polymorphisms on systemic inflammation

“…31 Insulin resistance is also linked to inflammatory cytokine stimulation. 32 Homocysteine was shown to be significantly associated with serum C4, CRP, and IgM level, 51 and DNA hypomethylation of some of genes was also shown to be an important factor in inflammation. 52 So it is possible that hyperhomocysteinemia and/or DNA hypomethylation cause systemic inflammation in MTHFR C677T variants patients, and systemic inflammation becomes a more direct and more relevant pathogenesis for MTHFR C677T polymorphism-related disease.…”

Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project

“…As described in our previous studies 27 , 28 , the FAMHES project was carried out from September to December 2009, and involved a routine physical examination at the Medical Center in Fangchenggang First People’s Hospital. The sample comprised 4303 non-institutionalized Chinese men aged 17 to 88 years old, who were from the Fangchenggang area of Guangxi, China.…”

Study of the Inflammatory Mechanisms in Hyperhomocysteinemia on Large-Artery Atherosclerosis Based on Hypersensitive C-Reactive Protein—A Study from Southern China

“…The levels of hs-CRP can reflect the composition of atherosclerotic plaques and predict the possibility of plaque rupture. 36 The studies 37 show that hs-CRP in serum are significantly associated with homocysteine concentration. A previous study 38 showed that hs-CRP was closely related to carotid plaque and IMT.…”