Serum hyaluronan as a predictor of hepatic regeneration after hepatectomy in humans

Ogata,; Okuda,; Ueno,; Saito,; Aoyagi,

doi:10.1046/j.1365-2362.1999.00513.x

Cited by 24 publications

(23 citation statements)

References 34 publications

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“…29 A high preoperative serum HA concentration was associated with impaired hepatic regeneration after hepatectomy. 11 We previously found that serum HA levels were inversely correlated with the regeneration rate of the remnant liver 9 and the present study showed the same tendency, although without significance. Because the regeneration of the injured liver is impaired, measuring the serum HA level before hepatectomy could help to predict the postoperative growth capacity of the diseased liver.…”

Section: Discussionsupporting

confidence: 74%

“…The findings of our preliminary study and those of others showed that serum HA concentrations were inversely correlated with measurements of functional liver reserve and the degree of hepatic fibrosis, suggesting that measuring the HA level might be useful for monitoring liver damage or predicting postoperative complications after hepatic resection. [4][5][6][9][10][11] We also found that the serum HA level in patients with normal liver function was significantly lower than that in patients with liver injury caused by chronic hepatitis, cirrhosis, or obstructive jaundice, and that there were few posthepatectomy complications in patients with prehepatectomy normal liver function. 9 Thus, we conducted this study on patients with injured liver diseases to determine the efficiency of measuring the serum HA level before and after hepatectomy.…”

Section: Introductionmentioning

confidence: 51%

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Preoperative Serum Hyaluronic Acid Level as a Good Predictor of Posthepatectomy Complications

et al. 2004

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 51%

Preoperative Serum Hyaluronic Acid Level as a Good Predictor of Posthepatectomy Complications

et al. 2004

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“…The serum HA level correlated with hepatic ATP levels and mortality rate after extensive hepatectomy in rats [42]. Ogata et al reported that preoperative serum HA concentrations > 200 ng/ml were associated with the inhibition of hepatic regeneration after hepatectomy [16]. Because major hepatectomy itself causes an increased risk of these postoperative complications, it would be difficult to determine extent of major hepatectomy in patients with a high HA level [43].…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study also showed that HA was significantly associated with poor hepatic function and postoperative complications such as longterm ascites and hepatic fibrosis [14,15]. HA might be the most important factor related to poor hepatic functional reserve [16]. Therefore, we hypothesized that the serum HA level, which is a marker of reliable hepatic function, could be applied to predict patient survival in HCC patients.…”

Section: Introductionmentioning

confidence: 96%

Relationship between Serum Hyaluronic Acid Level and Patient Prognosis in Hepatocellular Carcinoma Patients Who Underwent Hepatectomy

Nanashima¹,

Abo²,

Murakami³

et al. 2013

JCT

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We examined the relationship between hyaluronic acid (HA) and tumor-related factors after hepatectomy in 158 patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. We examined serum HA levels before hepatectomy by evaluating data for clinicopathological parameters, surgical records, postoperative complications and survival. The mean HA level was 190 ± 202 ng/ml. Patients were divided into 3 groups: group A had serum HA levels less than 50 ng/ml (normal range), group B had levels between 50 and 190 ng/ml, and group C had levels over 190 ng/ml. Group C had a higher rate of poor liver function compared to others. Multiple tumors were significantly more frequent in groups B and C compared to A. The grade of fibrosis and the inflammatory responses were positively correlated with the serum HA level. Postoperative long-term ascites was significantly more frequent in group C compared to others. Although the recurrence rate and the relapse-free period were not significantly related to the serum HA level, the serum HA level was significantly associated with overall survival after hepatectomy (p < 0.05). Cox's multivariate analysis did not show a significant relationship between HA level and survival. Serum HA reflects progression and survival in HCC patients.

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“…The serum HA level has been recognized not only as fibrosis or a functional marker of an injured liver [31], but also as a predictor of postoperative complications associated with liver surgery [13,14,15]. Previously, a serum HA level <160 ng/ml was reported to be the discrimination value in a major hepatectomy [15] and >200 ng/ml was reported to indicate an inhibition of liver regeneration after a hepatectomy [32]. In this study, the serum HA level was also a strong predictor for postoperative complications after major hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

A New Prediction Model of Postoperative Complications after Major Hepatectomy for Hepatocellular Carcinoma

et al. 2009

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Background/Aims: Serum hyaluronic acid (HA) concentrations reflect the degree of hepatic dysfunction and may have potential for predicting postoperative complications in a major hepatectomy for hepatocellular carcinoma (HCC). Methods: Serum HA concentrations and other conventional liver function tests were measured prior to major hepatectomies in 52 patients. Independent predictors for postoperative complications were analyzed and the discriminant equation was established and validated. Results: Postoperative complications occurred in 17 patients. Serum HA concentrations and the estimated remnant liver volume ratio (remnantVol%) were recognized as independent predictors for postoperative complications (OR 1.03, 0.85; CI 95% 1.01–1.06, 0.76–0.95; p = 0.006, 0.006; respectively) and produced the discriminant equation: logit = 4.15 + 0.03 × (HA) –0.16 × (remnantVol%). The value of the area under the curve of a receiver operating characteristic analysis was 0.92. If the cut-off of the logit value was set to 0, then the predictive accuracy was 0.88. The validation accuracy performed by a leave-one-out cross-validation method was 0.83. Conclusions: The constructed discriminant equation model consisting of the preoperative serum HA concentrations and estimated remnantVol% could be useful for predicting postoperative complications in a major hepatectomy for HCC.

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Serum hyaluronan as a predictor of hepatic regeneration after hepatectomy in humans

Abstract: It has been suggested that hepatic regeneration is closely related to both hepatic fibrosis and hepatic sinusoidal capillarization. The serum hyaluronan level is regarded as a useful predictor for hepatic regeneration after hepatectomy.

Cited by 24 publications

References 34 publications

Preoperative Serum Hyaluronic Acid Level as a Good Predictor of Posthepatectomy Complications

Preoperative Serum Hyaluronic Acid Level as a Good Predictor of Posthepatectomy Complications

Relationship between Serum Hyaluronic Acid Level and Patient Prognosis in Hepatocellular Carcinoma Patients Who Underwent Hepatectomy

A New Prediction Model of Postoperative Complications after Major Hepatectomy for Hepatocellular Carcinoma

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