Serum <i>β</i>-glucuronidase activity as a biomarker for acute cholinesterase inhibitor pesticide poisoning

Beltagy, Doha M.; Sadek, Kadry M.; Hafez, Amal

doi:10.1177/0748233718802068

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Nonetheless, mildly exposed subjects have been reported to show elevated bGLU activity than severely exposed and control subjects, which suggests the enzyme's utility for diagnosing lowlevels of OP exposure. For instance, a study [111], observed the order of serum bGLU activity based on poisoning severity as mild > severe > moderate poisoning, while the order after 12 and 24 h of admission was mild > severe z moderate poisoning; strong correlation also persisted between serum bGLU and BuChE activities. Similar results were also obtained in a recent cross-sectional study [112].…”

Section: Organophosphorus Pesticide Poisoningmentioning

confidence: 99%

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

Awolade

Cele

Kerru

et al. 2020

European Journal of Medicinal Chemistry

107

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BiomarkerEnzyme inhibition Molecular target Structure activity relationship a b s t r a c tThe emergence of disease and dearth of effective pharmacological agents on most therapeutic fronts, constitutes a major threat to global public health and man's existence. Consequently, this has created an exigency in the search for new drugs with improved clinical utility or means of potentiating available ones. To this end, accumulating empirical evidence supports molecular target therapy as a plausible egress and, b-glucuronidase (bGLU) e a lysosomal acid hydrolase responsible for the catalytic deconjugation of b-D-glucuronides has emerged as a viable molecular target for several therapeutic applications. The enzyme's activity level in body fluids is also deemed a potential biomarker for the diagnosis of some pathological conditions. Moreover, due to its role in colon carcinogenesis and certain drug-induced dose-limiting toxicities, the development of potent inhibitors of bGLU in human intestinal microbiota has aroused increased attention over the years. Nevertheless, although our literature survey revealed both natural products and synthetic scaffolds as potential inhibitors of the enzyme, only few of these have found clinical utility, albeit with moderate to poor pharmacokinetic profile. Hence, in this review we present a compendium of exploits in the present millennium directed towards the inhibition of bGLU. The aim is to proffer a platform on which new scaffolds can be modelled for improved bGLU inhibitory potency and the development of new therapeutic agents in consequential.

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Section: Organophosphorus Pesticide Poisoningmentioning

confidence: 99%

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

Awolade

Cele

Kerru

et al. 2020

European Journal of Medicinal Chemistry

107

View full text Add to dashboard Cite

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Biochemical responses as early and reliable biomarkers of organophosphate and carbamate pesticides intoxication: A systematic literature review

Sepahi

Gerayli

Delirrad

et al. 2022

J Biochem & Molecular Tox

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Inhibition of cholinesterase (ChE) activity has been long considered as the main diagnostic method of organophosphate (OP) and carbamate pesticides poisoning; however, it has been shown that ChE activity may also be altered due to exposure to other non-organophosphorus toxicants and variety of different medical conditions. Hence, to avoid misdiagnosis, we aimed to systematically review available documents to look for additional biomarkers of OP and carbamate poisoning. The electronic databases in addition to Google scholar were searched for eligible articles on March 2022 using "organophosphate," "carbamate," and "biomarker" including all their similar terms. After collecting the relevant documents, the data were extracted and described qualitatively. In total, data of 66 articles from 51 human and 15 animal studies were extracted. Findings demonstrated that enzymes such as β-glucuronidase, neuropathy target esterase, amylase, and lipase, in addition to hematological indicators such as CBC, CRP, lactate dehydrogenase, and CPK have high sensitivity and accuracy in the diagnosis of OP poisoning. Findings suggest that using various markers for diagnosis of OP intoxication is helpful for appropriate management, and early identifying the patients at risk of death. The suggested biomarkers also help to avoid misdiagnosis of OP poisoning with other similar conditions.

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β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis

Serafín-Fabian,

Elena Moreno-Godínez,

Flores-Alfaro

et al. 2023

Environmental Toxicology and Pharmacology

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Serum β-glucuronidase activity as a biomarker for acute cholinesterase inhibitor pesticide poisoning

Cited by 3 publications

References 27 publications

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

Biochemical responses as early and reliable biomarkers of organophosphate and carbamate pesticides intoxication: A systematic literature review

β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis

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