Serum IgA/C3 Ratio May Be a Useful Marker of Disease Activity in Severe Henoch-Schönlein Nephritis

Shin, Jae Il; Park, Jee Min; Shin, Youn Ho; Lee, Jae Seung; Jeong, Hyeon Joo; Kim, Hyun Sook

doi:10.1159/000086225

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…In present study, clinical features such as mean age, cutaneous palpable purpura lesions, and gastrointestinal bleeding symptoms were in accordance with diagnostic criteria [ 21 ]. Moreover, notably increased serum IgA and C3 levels implied that they might be helpful for the pathogenesis of acute HSP, which were also in accordance with previous reports [ 24 , 25 ].…”

Section: Discussionsupporting

confidence: 92%

Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura

Xie

Liu

Wang

et al. 2015

Journal of Immunology Research

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Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses. T follicular helper (TFH) cells play crucial roles in regulating immune responses. The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP. In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression. Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs. A positive correlation was observed between the frequencies of circulating ICOS+CXCR5+CD4+TFH cells and the serum IL-21 or IgA levels of acute HSP children, respectively. Additionally, the mRNA expression levels of interleukin- (IL-) 21, IL-6, and transcriptional factors (B-cell lymphoma-6, Bcl-6) were also significantly increased in peripheral blood from acute HSP children compared to HCs. Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children.

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Section: Discussionsupporting

confidence: 92%

Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura

Xie

Liu

Wang

et al. 2015

Journal of Immunology Research

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“…35 It has also been acknowledged that the serum IgA/C3 ratio may serve as a useful marker to predict disease activity in HSP patients. In a retrospectively study, Shin et al 36 found that the serum IgA/C3 ratio was subjected to a 2.3-fold increase in HSP patients with active renal disease than in patients with normal or minor abnormal urinalysis. In our patients with ISKDC grades II, IIIa, IIIb, the serum IgA/C3 ratios were 1.83 ± 0.65, 2.30 ± 0.63, 1.90 ± 0.99, respectively; the C3/C4 ratios were 6.23 ± 1.42, 6.48 ± 2.40, 6.03 ± 1.60, respectively.…”

Section: Discussionmentioning

confidence: 99%

Serum immunoglobulin profiles in Chinese children with Henoch‐Schönlein purpura

et al. 2022

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The present study focuses on the associations of serum immunoglobulin with disease activity, relapse/recurrence and renal involvement in Henoch‐Schönlein purpura (HSP) children. 1683 Chinese children with HSP were recruited from January 2015 to January 2021. Laboratory data of blood samples and urine tests were collected. Renal biopsy was performed by the percutaneous technique. Patients' histories associated with HSP onset were obtained by interviews and questionnaires. (1) IgA and IgE were dramatically elevated in HSP patients as compared to their normal values and subject to a 1.75–3.09 fold and a 1.97–2.61 fold increase, respectively. (2) No significant correlation of the disease activity with IgA and IgE was determined, respectively. (3) The serum IgA levels were significantly lower in patients with relapse/recurrence than that in patients without relapse/recurrence, which may be attributed to the transmission of IgA‐mediated immune complexes from blood to vessel walls. (4) No significant correlation was found between serum IgA, IgE levels and the pathological classification. HSP children have marked disorders of serum immunoglobulin profiles, characterized by significant increases in IgA and IgE. The detection of serum IgA may be applicable to predict relapse/recurrence of HSP whereas not associated with disease activity and renal involvement.

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“…According to pathological and laboratory findings of IgA deposits on small vessel wall and increased serum levels of IgA, it is speculated that HSP is an immune-mediated vasculitis (Ballinger 2003). Therefore, IgA/C3 ratio has been proposed as a marker to predict disease activity (Shin et al 2005). Our study found that IgA/C3 ratio was higher in HSP than that in controls but this ratio was similar in HSP patients with or without proteinuria, hematuria and SOB (Tables 3 and 4).…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3 in Henoch-Schonlein Purpura

Yıldız

Kural

Aydın

et al. 2008

Tohoku J. Exp. Med.

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TurkeyHenoch-Schönlein purpura (HSP) is a common systemic vasculitis of childhood, and may affect the kidney. Endothelial cell dysfunction and fibrosis is an important part of HSP vasculitis and may account for renal involvement in HSP. Insulin-like growth factor (IGF)-1 enhances the cytokine-induced expression of adhesion molecules in endothelial cells (EC). Besides, IGF-1 may stimulate angiogenesis, fibrosis and tubular formation in EC and IGF-1 increases glomerular filtration rate. We, therefore, investigated the role of IGF-1 and IGF-binding protein-3 (IGFBP-3) in HSP. The study included 44 patients with HSP (30 boys and 14 girls), including 13 patients with proteinuria, 15 patients with hematuria and 16 patients with positive stool occult blood (SOB), and 26 healthy children. Serum levels of IGF-1 and IGFBP-3 levels were significantly higher in HSP than in the controls (147.9 ± 121.6 vs 95.7 ± 67.8 ng/ml, p = 0.024 and 4.4 ± 2.2 vs 2.3 ± 0.9 μ g/ml, p = 0.001, respectively). Serum IGF-1 levels were significantly higher in HSP with proteinuria than those without proteinuria and controls ( p = 0.001 and p = 0.001, respectively). Also, IGFBP-3 levels were greater in HSP with proteinuria compared to those without proteinuria and controls ( p = 0.005 and p = 0.0001). Serum immunoglobulin-A/ complement-C3 ratio was higher in HSP than in the controls ( p = 0.0001) but this ratio did not change according to proteinuria, hematuria or positive SOB. In conclusion, IGF-1 and IGFBP-3 levels could be new markers for determination of renal involvement in HSP.Henoch-Schönlein purpura; insulin-like growth factor-1; insulin-like growth factor-binding protein-3; proteinuria; hematuria. As an inflammatory disease, HenochSchöenlein purpura (HSP) is the most common systemic vasculitis in children characterized by narrowing of the small vessels lumen and IgA deposition (Tizard 1999). Although there seems to be a temporal relationship between HSP and recent respiratory infections, exposure to allergens, drugs, cold and insect bites, pathophysiolo-

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Serum IgA/C3 Ratio May Be a Useful Marker of Disease Activity in Severe Henoch-Schönlein Nephritis

Cited by 11 publications

References 41 publications

Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura

Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura

Serum immunoglobulin profiles in Chinese children with Henoch‐Schönlein purpura

Increased Serum Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3 in Henoch-Schonlein Purpura

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