Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease

Abstract

BackgroundPrevious reports showed that some patients with minimal change disease (MCD) had high serum immunoglobulin E (IgE) levels. This study aimed to explore the proportion of MCD patients with high serum IgE levels and evaluate the correlation between serum IgE levels and MCD remission and relapse.MethodsThis study enrolled 222 new-onset patients with renal biopsy-confirmed MCD from October 2012 to October 2019 at the First Affiliated Hospital of Zhejiang University in Hangzhou, China. Patients’ demographics and clinical parameters were analyzed.ResultsThe results indicated that 70.3% of 222 MCD patients had high serum IgE levels (IgE > 100.0 IU/mL). Moreover, 134 patients were treated with glucocorticoids alone and divided into the low- and high-IgE groups, according to the median serum IgE level (523.5 IU/mL). The mean time to complete remission of the low- and high-IgE groups was 29.0 ± 2.2 and 45.7 ± 4.2 days, respectively (log-rank test; P = 0.002). The mean time to total remission was 19.1 ± 1.4 and 31.6 ± 3.2 days of the low- and high-IgE groups, respectively (log-rank test; P < 0.001). The mean time to first relapse in the low- and high-IgE groups was 701.2 ± 65.0 and 425.0 ± 52.6 days, respectively (log-rank test; P = 0.002). Serum IgE ≥ 523.5 IU/mL was an independent correlation factor affecting the patients’ remission and relapse.ConclusionSerum IgE level was an independent correlation factor for MCD remission and relapse. MCD patients with high serum IgE levels were prone to delayed remissions and early relapses.

Serum IgE levels are a risk factor with prognosis of pediatric minimal change disease

“…Serum IgE was persistently and significantly higher in FRNS than IFRNS ( 23 ). In our study, it was found that the time to first relapse of MCD children in the high-IgE group was significantly shorter, which was consistent with other studies’ results ( 7 , 24 ). In addition, a higher percentage of MCD patients experienced FR in the high-IgE group.…”

“…Serum IgE levels may not only reflect disease activity but may also implicate disease outcome in childhood of INS ( 5 , 6 ). A recent study reported that MCD patients with high-IgE levels were observed to prolong first reach disease remission and prone to early relapses ( 7 ). Fewer relevant studies have been performed in pediatric and biopsy-proven MCD patients about correlation between serum IgE levels and prognosis of MCD.…”

Associations between Total Immunoglobulin E Levels and Urinary Albumin Excretion: A Cross-Sectional Study

“…Previous studies have found a strong relationship between renal disease and atopy accompanied by heightened serum IgE antibodies [18]. Lee et al [10] found that the serum IgE level increased in immunoglobulin A nephropathy patients with renal deterioration.…”

“…Lee et al [10] found that the serum IgE level increased in immunoglobulin A nephropathy patients with renal deterioration. Another study indicated that the serum IgE level was an independent predictor of NS recurrence [18]. Likewise, Cheung et al [19] found higher IgE levels during NS relapse compared to remission.…”

Immunoglobulin-E (IgE) Screening for Detecting Mouthwash Allergic Reactions with Recurrent Oral Erythema Multiforme: A Case Report

“…13,14 Under normal conditions, serum IgE levels are generally low, and increased levels tend to coincide with allergic reactions. 15 The purpose of this report is to describe the advantages of total IgE screening for detecting mouthwash allergic reactions associated with recurrent erythema oral multiforme (ROEM).…”