Serum IL-6 and IL-8 Correlate with Prognostic Factors in Ovarian Cancer

Abstract

The aim of the study was to correlate serum levels of IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α with clinical, laboratory, and pathological prognostic factors in patients with primary ovarian malignancy. Patients treated at the Pelvic Mass Ambulatory of the Discipline of Gynecology and Obstetrics/Oncology Research Institute (IPON) of the UFTM with confirmed diagnosis of malignant ovarian neoplasia (n = 26) were evaluated. Serum collection was performed preoperatively for the determination of tumor markers. The cytokines IL-2, IL-5, IL-6, IL-8, IL-10, and TNF-α were assayed by enzyme-linked immunosorbent assay (ELISA). The prognostic factors were compared using the Mann-Whitney test, with significance level lower than 0.05. When evaluating IL6, it was observed that higher serum levels were associated with overall survival less than 60 months (p = 0.0382). In the evaluation of IL8, higher serum levels were associated with neutrophil-to-lymphocyte ratio (NLR) ≥ 4 and platelet-to-lymphocyte ratio (PLR) ≥ 200 (p = 0.0198 and p = 0.0072, respectively), altered values of serum CA125 (p = 0.0457), and stage IIIC (p = 0.0486). Therefore, increased levels of IL-6 and IL-8 are associated with factors of worse prognosis in ovarian cancer. Additional studies with a larger sample of patients are needed to confirm the role of cytokines as prognostic factors, in the definition of treatment, and in the development of future target therapies.

Early Loss of Histone H2B Monoubiquitylation Alters Chromatin Accessibility and Activates Key Immune Pathways That Facilitate Progression of Ovarian Cancer

“…This suggests that IL6 secretion is enhanced in RNF20-depleted cells, which could stimulate autocrine and/or paracrine signaling to modulate the tumor microenvironment and promoting tumor progression. In line with our data, previous studies have shown that high IL6 in HGSOC is correlated with therapy resistance and poor prognosis (36,37). Mechanistically, it is likely that IL6 is operating through the JAK/STAT pathway in FT cells, but further studies are needed to define the precise intracellular response to IL6 in FT cells (38).…”

Comparative analysis of abdominal fluid cytokine levels in ovarian hyperstimulation syndrome (OHSS)

“…In contrast, ascites was not detected in the BAM and EM patients. Recent studies also propose that increased serum levels and peritoneal cavity levels of both IL-6 and IL-10 are associated with factors of worse prognosis in ovarian cancer patients [6,7].…”

“…Despite greater insights into the etiology of OHSS, the exact pathomechanism remains unclear. It has been hypothesized that local vasoactive mediators, such as vascular endothelial growth factor (VEGF), substances belonging to the renin-angiotensin system, and cytokines such as interleukin (IL)-6 and IL-8, play major roles in disease pathogenesis [5][6][7][8][9]. These factors can potentially induce fluid redistribution and massive extravasation, thereby resulting in a state of hypovolemic hyponatremia with hemoconcentration, as well as hypercoagulability [8,9].…”

IL‐8 promotes cell migration through regulating EMT by activating the Wnt/β‐catenin pathway in ovarian cancer

“…IL-8 levels of ovarian cancer, the increase in IL-8 levels was found to be related to the negative prognostic factors of ovarian cancer 18. …”