Serum IL-9, IL-17, and TGF-β levels in subjects with diabetic kidney disease (CURES-134)

Vasanthakumar, Rathinam; Mohan, Viswanathan; Anand, Gowrisankar; Deepa, Mohan; Babu, Subash; Aravindhan, Vivekanandhan

doi:10.1016/j.cyto.2014.10.009

Cited by 42 publications

(36 citation statements)

References 13 publications

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“…21 The increased levels of TGF-b1 is closely associated with the kidney damage, for example, the gene transfer of TGF-b1 in the mesangium of normal rats results in glomerulosclerosis, 22 the TGF-b1 production is increased in human kidney diseases such as diabetic nephropathy and allograft nephropathy. 23 In this sense, TGF-b1 overproduction is closely associated with the risk of CKD. Second, TGF-b1 secretion and production is genetically regulated.…”

Section: Discussionmentioning

confidence: 99%

Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases

2015

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The association of transforming growth factor-b1 (TGF-b1) polymorphisms with the risk of chronic kidney diseases (CKD) remains elusive. We aimed to perform a meta-analysis to evaluate the relationship between TGF-b1 polymorphisms and the susceptibility to CKD. Association studies were searched according to a defined criteria using electronic databases. The strength of association between TGF-b1 polymorphisms and CKD risk was evaluated by odds ratio (OR) with the corresponding 95% confidence interval (CI). Nine case-control studies were identified. T allele at the +869 T/C polymorphism was associated with a lower risk of CKD in Asians (p ¼ 0.003). TT genotype at the +869 T/C polymorphism was associated with a lower risk of CKD in overall populations and Asians (p ¼ 0.007 and 510 À4

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Section: Discussionmentioning

confidence: 99%

Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases

2015

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“…IL-9 also showed a positive correlation with urea and microalbuminuria. These results suggest the involvement of these cytokines in the DKD, but more studies are needed to further elucidate their role [109].…”

Section: Based On Cytokines Profile and Effector Function Cd4 + T Hementioning

confidence: 87%

Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis

Araújo¹,

Silva²,

Silva³

et al. 2016

JDM

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Diabetic Nephropathy (DN) is considered the main cause of end stage kidney disease around the world. However, its pathogenesis is not completely established. More than just a direct consequence of chronic glycemic changes, recent studies had suggested Diabetic Nephropathy could be considered an inflammatory disease. It has been shown that concentrations of pro-inflammatory cytokines, as IL-1, IL-6, IL-18, IL-33, IFN-γ and TNF-α actively participate in development and progression of DN, and thus, are involved in pathogenesis. Besides, changes in acquired immune response, especially the presence of cellular immune response profiles of pro-inflammatory and effector nature, mainly Th1 and Th17, as the imbalance between interaction of cytokines and T regulatory cells, foment the onset and progression of DN. Here we summarize the main evidences that support the critical role of the immune system in this condition. These new conceptual advances in DN understanding are essential for development of new the rapeutical strategies and prognostic factors, which could be protagonists or adjuvants to the current ones, leading ultimately to a better clinical management of DN patients.

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“…Sirota et al (38) have demonstrated that plasma IL-8 is a biomarker of acute kidney injury. Vasanthakumar et al (39) suggested that IL-17 was positively and negatively correlated with fasting and postprandial glucose levels, respectively, and glycated hemoglobin (HbA1c) was observed in subjects with diabetic kidney disease. Ahuja et al (40) indicated that that circulating IL-6 mediates inflammatory responses via CXCL1 production following acute kidney injury in mice.…”

Section: Discussionmentioning

confidence: 99%

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

Wang

Guo

et al. 2017

Exp Ther Med

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Abstract. Chemokines are a class of proteins with low molecular weight that serve important roles in the progression of inflammation. Percutaneous nephrolithotripsy is a surgical technique in which lasers or ultrasound are utilized to break down and/or remove kidney stones. In order to ensure a full recovery following surgery, effective patient care and nursing are required. In the present study, a total of 348 patients with kidney stones were recruited and the clinical importance of chemokines and inflammatory cytokines for the nursing of patients during perioperative period was investigated. Plasma levels of inflammatory cytokines, as well as chemokines in the C, CC and CXC families, were analyzed in patients following percutaneous nephrolithotripsy. Correlations between chemokines and inflammatory cytokines and the urinary concentration of calcium oxalate were also investigated. The results indicated that plasma levels of C and CC chemokines were downregulated in patients following percutaneous nephrolithotripsy, whereas the plasma concentrations of CXC chemokines were upregulated. Plasma concentration levels of inflammatory cytokines interleukin (IL)-8, IL-1, IL-17 and tumor necrosis factor (TNF)-α were significantly downregulated in patients following percutaneous nephrolithotripsy; however, no significant differences were observed in plasma levels of IL-6 and IL-10 pre-and post-surgery. Regression analysis revealed that plasma concentration levels of chemokine C motif ligand, which is a C chemokine, chemokine ligand 2, which is a CC chemokine, and TNF-α were positively correlated with the urinary concentration of calcium oxalate during the perioperative period. The results of the present study indicate that plasma levels of chemokines and inflammatory cytokines are clinically important for nursing of patients who experienced percutaneous nephrolithotripsy. IntroductionKidney stones are a common problem affecting the urinary system that significantly affect metabolism and impede physical activity (1). Studies investigating the causes of disease have reported that several factors contribute to the formation of stones, including age, sex, ethnicity, genetic and environmental factors, dietary habits, occupation, metabolic abnormalities, urinary tract obstruction, infection and drug use (2,3). Clinical pathology has demonstrated that calcium oxalate is the primary constituent of kidney stones (4). Percutaneous nephrolithotripsy is a commonly used and effective surgical treatment for solitary kidney stones (5,6). Laparoscopy-assisted transmesocolonic percutaneous nephrolithotripsy is considered to be a safe and effective treatment option in cases of ectopic kidney stone disease (7). Clinical care is important for recovery from percutaneous nephrolithotripsy in clinical patients (8).Chemokines are a class of low molecular weight proteins that attract white blood cells to infection sites and serve an important role in immunological surveillance (9,10). Previous studies have suggested that chemokine levels may be u...

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Serum IL-9, IL-17, and TGF-β levels in subjects with diabetic kidney disease (CURES-134)

Cited by 42 publications

References 13 publications

Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases

Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases

Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

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