Serum immune response to Helicobacter pylori in children: Epidemiologic and clinical applications

Giacomo, Costantino De; Lisato, Laura Camilla; Negrini, Riccardo; Licardi, G; Maggiore, Giuseppe

doi:10.1016/s0022-3476(05)80728-0

Cited by 74 publications

(42 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It may take more than 6 months after treatment to become seronegative. 14,16,29 A 20% reduction of the IgG antibody titers by 6 months suggests successful eradication therapy, whereas no reduction suggests persistent H pylori infection. 30 On the other hand, one study showed a decrease of antibody titers in half of the children with persistent H pylori infection.…”

Section: Discussionmentioning

confidence: 99%

Omeprazole-based Dual and Triple Regimens forHelicobacter pyloriEradication in Children

et al. 1997

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Omeprazole-based Dual and Triple Regimens forHelicobacter pyloriEradication in Children

et al. 1997

View full text Add to dashboard Cite

show abstract

“…8,27,30,78,94 Rothenbacher et al 119 estudaram a prevalência do H. pylori em 1.143 crianças e seus respectivos acompanhantes (n=1.074) mediante teste respiratório com C 13 -uréia. Os autores concluíram que pais infectados, especialmente as mães, podem desempenhar importante papel na transmissão do H. pylori entre familiares, à semelhança do que se observa em relação a outras bactérias da cavidade oral, como é o caso do Streptococcus mutans.…”

Section: Unidade Familiarunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

View full text Add to dashboard Cite

Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

show abstract

“…H. pylori infection tends to cluster in families and in people living in crowded or close conditions. For this reason, it is widely believed that impoverished children may acquire H. pylori through contact with their mothers (5,10,12,14,18). To test this idea, we compared the H. pylori serologic status of the mothers of the children enrolled in our study to that of the sera collected most recently from their children.…”

mentioning

confidence: 99%

Age-Specific Helicobacter pylori Seropositivity Rates of Children in an Impoverished Urban Area of Northeast Brazil

et al. 2003

View full text Add to dashboard Cite

We determined age-specific Helicobacter pylori seropositivity rates of 166 children and 39 mothers in an urban shantytown in northeast Brazil. Seropositivity rates increased from 23.1% at 0 to 11 months of age to only 39.3% by 96 to 131 months of age and were 82.1% at maturity. We observed no correlation between the seropositivity of the mothers and the seropositivity of their children.Accumulating evidence suggests that Helicobacter pylori is acquired in early childhood and infects more people in developing countries than in industrialized countries (1,3,4,11). In impoverished areas of developing countries, the H. pylori seropositivity rate by 20 years of age has been shown to be more than 80%, much greater than the 30% seropositivity rate by 30 years of age in industrialized countries (3,6,18). Furthermore, a study of 141 adults showed no significant change in H. pylori infection rates from 1969 to 1990, suggesting that acquisition of H. pylori in adulthood does not play a large role in the high seropositivity rates seen in developing countries (4).In order to understand the transmission and health impact of H. pylori infection, a focus on early childhood infection is necessary (12). Our report presents new age-specific H. pylori seropositivity rates and suggests that neither mother-to-child nor waterborne transmission of the pathogen can account for whom is infected and when the infection occurs.The subjects in this study live in Gonçalves Dias, a slum of FIG. 1. Age-specific seropositivity rates of subjects living in an impoverished urban area of northeast Brazil increased to 39.3% by age 10, before reaching 82% by maturity. Most subjects in our study did not acquire H. pylori infection very early in childhood. n, number of samples.

show abstract

Serum immune response to Helicobacter pylori in children: Epidemiologic and clinical applications

Cited by 74 publications

References 20 publications

Omeprazole-based Dual and Triple Regimens forHelicobacter pyloriEradication in Children

Omeprazole-based Dual and Triple Regimens forHelicobacter pyloriEradication in Children

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Age-Specific Helicobacter pylori Seropositivity Rates of Children in an Impoverished Urban Area of Northeast Brazil

Contact Info

Product

Resources

About