Serum Insulin-Like Growth Factor 1 In Lebanese Schoolchildren And Its Relation To Vitamin D And Ferritin Levels

Gannagé‐Yared, Marie‐Hélène; Chahine, Elise; Farah, Vanessa; Ibrahim, Tony; Asmar, Nadia; Halaby, Georges

doi:10.4158/ep161623.or

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…Both for boys and girls, before applying correction factors (i.e., age, BMI and pubertal development), an inversely proportional relationship was found between the IGF-1 and 25(OH)D values. This relationship was no longer evident after adjustment according to the correction factors for the IGF-1 values [68].…”

Section: Vitamin D Metabolism and Gh In Clinical Pediatric Studiesmentioning

confidence: 99%

“…Of the six studies reported, only two identified a direct proportionality between the levels of 25(OH)D and the levels of IGF-1 at baseline. Both the study of Marwaha and of Gannagé-Yared have shown a possible inversely proportional relationship between 25(OH)D and IGF-1 levels such that without applying conversion factors such as age, BMI and pubertal stage, the subjects with vitamin deficiency D had higher IGF-1 values [67, 68]. A hypothesis to justify such conflicting results is the possibility that vitamin D metabolites behaves differently on the GH/IGF-1 axis depending on whether the subject has a vitamin D deficiency or normal values.…”

Section: Critical Analysis Of the Relationship Between Vitamin D Metamentioning

confidence: 99%

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Vitamin D and growth hormone in children: a review of the current scientific knowledge

et al. 2019

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BackgroundHuman growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). In contrast, vitamin D is involved in the processes of bone growth and mineralization through the regulation of calcium and phosphorus metabolism. Nevertheless, no scientific study has yet elucidated how they interact with one another, especially as a dysfunction in which one influences the other, even if numerous biochemical and clinical studies confirm the presence of a close relationship.Main bodyWe reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations. We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1. Although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis D in the subjects affected by GHD, a reduced possibility of its correction with only substitution treatment with recombinant growth hormone (rGH) and an improvement of IGF-1 levels after supplementation treatment with vitamin D.ConclusionsThese results could be followed by preventive interventions aimed at reducing the vitamin D deficit in pediatric age. In addition, further research is needed to fully understand how vitamin D and growth are intertwined.

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Section: Vitamin D Metabolism and Gh In Clinical Pediatric Studiesmentioning

confidence: 99%

Section: Critical Analysis Of the Relationship Between Vitamin D Metamentioning

confidence: 99%

Vitamin D and growth hormone in children: a review of the current scientific knowledge

et al. 2019

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“…Практично не досліджено вплив вітаміну D на функціонування системи ГР/ІЧР-1 у дітей та підлітків із захворюваннями ендокринної системи, зокрема не вивчена роль вітаміну D у патогенезі різних форм патології росту й фізичного розвитку [18].…”

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An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature

Bolshova

Kvacheniuk

Muz

et al. 2022

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There are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vitamin D and GH/growth factor system remains unclear. It was found that vitamin D is able to increase IGF-1 level in healthy individuals. Linear growth is accelerated after treatment of vitamin D deficiency in children, which may indicate the linking role of vitamin D between the proliferative cells of the growth plate cartilage and GH/growth factor system.Research objective: to determine 25-hydroxyvitamin D level in blood plasma in children with short stature, depending on the state of GH/IGF-1 system.Materials and methods. Study included 101 children with short stature: 33 children with partial somatotropic insufficiency (group 1); 44 children with complete somatotropic insufficiency (group 2); 24 children with syndrome of biologically inactive GH (group 3). Patients in groups 1 and 2 had a confirmed GH deficiency and a decrease or sharp decrease in of IGF-1 level; patients in group 3 had a normal stimulated release of GH against the background of a reduced IGF-1 level. GH, IGF-1, 25-hydroxyvitamin D, thyroid-stimulating hormone, and free thyroxine were determined in all children.Results. The average level of vitamin D in three groups corresponded to the vitamin deficiency according to international standards and was 52.24 ± 5.99 nmol/l in patients with partial somatotropic insufficiency, 67.6 ± 5.35 nmol/l in patients with complete somatotropic insufficiency and 58, ± 7.91 nmol/l in patients with syndrome of biologically inactive GH. A direct correlation was found between vitamin D and background GH level, stimulated GH level in children with both partial and complete somatotropic insufficiency. A direct correlation between vitamin D and IGF-1 level in this group of patients was also detected.Conclusions. It is advisable to determine the serum 25(OH)D in all children with short stature. Vitamin D levels should be taken into account in insulin/clonidine diagnostic tests in order to obtain a realistic indication of stimulated GH and IGF-1 levels.

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Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency

Durá-Travé

Gallinas-Victoriano

Moreno-González

et al. 2020

J Endocrinol Invest

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Serum Insulin-Like Growth Factor 1 In Lebanese Schoolchildren And Its Relation To Vitamin D And Ferritin Levels

Cited by 8 publications

References 34 publications

Vitamin D and growth hormone in children: a review of the current scientific knowledge

Vitamin D and growth hormone in children: a review of the current scientific knowledge

An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature

Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency

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