Serum Insulin-Like Growth Factor Type 1, Insulin-Like Growth Factor-Binding Protein-1, and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Patients with Thyroid Dysfunction

Iglesias, Pedro; Bayón, Carmen; Méndez, José Manuel Gómez y; Gancedo, Pilar G.; Grande, Cristina; Díez, Javier

doi:10.1089/105072501753271734

Cited by 51 publications

(41 citation statements)

References 32 publications

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“…Insulin-like growth factor I levels are low in adults with hypothyroidism and may normalize after thyroid hormone replacement therapy [3,28]. In hyperthyroidism, IGF-I levels have been shown to be normal or elevated and to decrease following antithyroid treatment with either total thyroidectomy or methimazole [3].…”

Section: Thyroid and Adrenal Diseasementioning

confidence: 99%

IGF-I measurements in the diagnosis of adult growth hormone deficiency

Kwan

Hartman

2007

Pituitary

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Although serum insulin-like growth factor I (IGF-I) concentrations have utility as a screening test for growth hormone (GH) deficiency in children and young adults, they are less accurate for screening in adults over 40 years of age. There are two main limitations in the clinical use of IGF-I levels as a marker of GH secretion. First, IGF-I synthesis is not only regulated by GH but also by nutrient supply and by other hormones; second, low IGF-I levels in the presence of normal or increased GH secretion may reflect a peripheral resistance to GH action. Although serum IGF-I cannot be used as a stand-alone test for the diagnosis of adult GH deficiency, very low IGF-I levels in the context of documented hypothalamic or pituitary disease may be helpful in identifying patients with a high probability of GH deficiency. In the presence of two or more additional pituitary hormone deficiencies, an IGF-I level <84 microg/l (assayed by Esoterix Endocrinology, Inc. Calabasas Hills, CA, USA) indicates a 99% probability of GH deficiency. As this cut-off value has not been validated for other IGF-I assays, an IGF-I standard deviation score (SDS) of <-3 may be considered in adults over age 28; an even lower IGF-I SDS is needed for diagnosis in younger adults. In clinical practice, other causes of low serum IGF-I such as malnutrition, diabetes, hypothyroidism, liver disease, etc., should be excluded before applying these diagnostic criteria.

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Section: Thyroid and Adrenal Diseasementioning

confidence: 99%

IGF-I measurements in the diagnosis of adult growth hormone deficiency

Kwan

Hartman

2007

Pituitary

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“…Previous studies reported discrepant results regarding circulating IGF1 levels: lower, 8,9 unmodified 10,11 or even higher values [12][13][14] in hyperthyroid compared to euthyroid patients. These discrepant results may be due to different laboratory tests used, changes in the number of IGF1R, 21,22 an interaction between the anabolic effect of IGF-related peptides and the catabolic thyrotoxic condition 16 or changes associated with nutritional signals and/or energy balance.…”

Section: Discussionmentioning

confidence: 99%

“…9 Iglesias et al demonstrated in 2001 that hypothyroidism is associated with significant reductions of IGF1 and IGFBP3 and that IGFBP1 is elevated in both hypothyroidism and hyperthyroidism. 10 Co ng et al showed, in a study performed on adolescent hyperthyroid patients, that hyperthyroidism does not cause alterations in the serum concentrations of either free or total IGF1. In the same study, both serum IGFBP2 and IGFBP3 concentrations were elevated during hyperthyroidism and correlated with serum T4 levels.…”

Section: Introductionmentioning

confidence: 98%

IGF1 deficiency in newly diagnosed Graves’ disease patients

Martin

Sîrbu

Betivoiu

et al. 2015

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OBJECTIVE: Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels and the main characteristics of Graves' disease (GD): severity of hyperthyroidism, goiter size, presence of active Graves' ophthalmopathy (GO), antythyroid antibodies status and titer. DESIGN AND METHODS: This cross-sectional study included 98 newly diagnosed hyperthyroid patients with GD who presented consecutively at our clinic. The main measured parameters were: TSH, FT4, FT3, TT3, thyroglobulin, anti-thyroid peroxidase antibodies (TPOAb), anti-thyroglobulin antibodies (ATA), thyrotropin receptor antibodies (TRAb), IGF1. Patients were considered IGF deficient if IGF1 z score was ≤-2SD from mean for age. RESULTS: In GD patients, men had higher IGF1 levels (p=0.023) and IGF1 z scores (p=0.013) than women. 18.4% of GD patients were, at diagnosis, IGF1 deficient. Compared to patients without IGF1 deficiency, these patients presented higher thyroglobulin (median=72.55, IQR=116.02 vs median=11.40, IQR=80.74 ng/ml, p=0.002) and FT3 (median=11.30, IQR=7.64 vs median=7.33, IQR=5.72 pg/ml, p=0.027), and lower ATA (median=20, IQR=0 vs median=34.05, IQR=161 iu/ml, p<0.001) levels. Thyroglobulin was independently associated with IGF1 deficiency (AUROC=0.732, 95% CI: 0.620-0.844, p=0.002; cut-off for thyroglobulin=50.40 ng/ml, Se=77.8%, Sp=70%). IGF1 status was not influenced by gender (p=0.084), current smoking (p=0.558), goiter size (p=0.533), active ophthalmopathy (p=0.334), TRAb (p=0.239) or TPOAb status (p=0.367). CONCLUSIONS: Nearly one fifth of newly diagnosed GD patients had IGF1 deficiency. IGF1 deficiency was associated with lower ATA titers, higher thyroglobulin levels and more severe FT3 hyperthyroidism at diagnosis.

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“…This may be a limitation of our study. Although the relationships between thyroid hormones and GH/IGFs axis are complex and not fully understood, results of clinical investigations generally suggest that there is a decrease in IGF-1 and IGFBP-3 in patients with hypothyroidism and that these molecules significantly increase following L-T 4 replacement therapy [21][22][23][24][25][26][27]. Due to the existence of strong correlations between age and IGF-1/ IGFBP-3 [28], the continuity of relationships between IGF-1/IGFBP-3 and thyroid hormones (T 3 , fT 4 ) after adjustment for age is in agreement with previous studies that suggest close relationships between GH/IGF axis and thyroid functions [2,21,23].…”

Section: Discussionmentioning

confidence: 99%

Kidney growth in children with congenital hypothyroidism

et al. 2009

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The effect of hypothyroidism on kidney size has not been studied in children. The aim of this study was to examine the role of congenital hypothyroidism and levothyroxine (L-thyroxine) treatment on renal growth. Forty children with congenital hypothyroidism and 37 healthy controls were prospectively included. The mean age of patients was 8.2+/-4.7 years. Patients had lower height and weight standard deviation scores compared with controls. The mean L-thyroxine initial age and treatment duration were 37.0 and 60.5 months, respectively. In 62.5% of patients, L-thyroxine was initiated after 6 months of age, and 60.0% of patients had severe hypothyroidism. Patients had lower kidney length and total kidney volume compared with controls (P < 0.05). No significant differences were found in kidney volume/body weight and kidney volume/ body height ratios between patients and controls (P > 0.05). Multiple regression analysis showed significant relationship between relative kidney volume and average free thyroxine level (P < 0.05). No significant differences in kidney sizes were found between patients who had L-thyroxine initiated before and after 6 months of age or between mild/moderate and severe hypothyroidism at diagnosis (P > 0.05). In conclusion, normal renal growth can be accomplished with L-thyroxine replacement despite considerable delay in treatment initiation and/or severe hypothyroidism.

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Serum Insulin-Like Growth Factor Type 1, Insulin-Like Growth Factor-Binding Protein-1, and Insulin-Like Growth Factor-Binding Protein-3 Concentrations in Patients with Thyroid Dysfunction

Cited by 51 publications

References 32 publications

IGF-I measurements in the diagnosis of adult growth hormone deficiency

IGF-I measurements in the diagnosis of adult growth hormone deficiency

IGF1 deficiency in newly diagnosed Graves’ disease patients

Kidney growth in children with congenital hypothyroidism

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