Serum Interleukin‐37: a new player in Lupus Nephritis?

Tawfik, Mirella Youssef; Nasef, Samah Ismail; Omar, Hanan Hassan; Ghaly, Mona

doi:10.1111/1756-185x.13122

Cited by 22 publications

(15 citation statements)

References 19 publications

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“…It was reported the elevated serum levels of interleukin-37 was correlated with poor prognosis in gastric cancer (38). The level of IL-37 in the serum of renal cell carcinoma patients was significantly lower than that in a healthy control group and was negatively correlated with the TNM Classification of Malignant Tumors (TNM) stage of the tumor (39). When IL-37 levels are normal, non-hepatocellular carcinoma tissues are minimal and negatively correlated with the tumor size, microvascular metastasis, and BCLC staging of hepatocellular carcinoma (40).…”

Section: Discussionmentioning

confidence: 98%

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

Zhao

Chen

et al. 2021

Front. Oncol.

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N6-methyladenosine (m6A) is a common transcriptomic modification in cancer. Recently, it has been found to be involved in the regulation of non-small cell lung cancer (NSCLC) formation and metastasis. Interleukin 37 (IL-37) plays a crucial protective role in lung cancer. In our previous studies, we found that IL-37 is a potential novel tumor suppressor by inhibiting IL-6 expression to suppress STAT3 activation and decreasing epithelial-to-mesenchymal transition. Moreover, we found that treatment of IL-37 in lung cancer cells induced widespread and dynamic RNA m6A methylation. The effects of RNA m6A methylation of IL-37 treatment require further study. However, the functions of RNA m6A methylation of IL-37 treatment still await elucidation. Using MeRIP-seq and RNA-seq, we uncovered a unique m6A methylation profile in the treatment of IL-37 on the A549 cell line. We also showed the expression of m6A writers METTL3, METTL14, and WTAP and erasers ALKBH5 and FTO in A549 cells and lung cancer tissues after the treatment of IL-37. This study showed that IL-37 could lead to changes in m6A methylation level and related molecule expression level in A546 cells and may downregulate the proliferation by inhibiting Wnt5a/5b pathway in A549 cells. We conclude that IL-37 suppresses tumor growth through regulation of RNA m6A methylation in lung cancer cells.

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Section: Discussionmentioning

confidence: 98%

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

Zhao

Chen

et al. 2021

Front. Oncol.

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“…It exerts critical effects on inflammation and modifies the activation of lymphocytes (L. Wang, Quan, Yue, Heng, & Che, ). Accumulated data have implicated that IL‐37 plays an important role in regulating both innate and adaptive immune responses (Tawfik, Nasef, Omar, & Ghaly, ; Zhao et al, ). In addition, growing bodies of data have revealed that IL‐37 is capable of suppressing the production of inflammatory cytokines, for instance, tumor necrosis factor‐α (TNF‐α) and IL‐6 (L. Wang, Quan, et al, ; L. Wang, Wang, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of microRNA‐657 influences inflammatory response via targeting interleukin‐37 in gestational diabetes mellitus

Wang

et al. 2018

Journal Cellular Physiology

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A number of studies have implicated that microRNAs (miRNAs) play a critical role in the development of gestational diabetes mellitus (GDM). However, the role of miR-657 in GDM remains vague up to date. We aim to investigate the modifying effect of miR-657 on GDM, which will provide new insight into the pathogenesis of GDM and may help to identify new diagnostic or therapeutic targets for GDM. Increased expression of miR-657 but decreased expression of interleukin-37 (IL-37) was observed in patients with GDM. Besides, negative association between miR-657 and IL-37 was demonstrated in this study. miR-657 could targetedly regulate IL-37 and enhance the proliferation of mononuclear macrophages. Moreover, miR-657 promoted the generation of inflammatory cytokines (IL-6 and tumor necrosis factor-α [TNF-α]) and activation of nuclear factor κB (NF-κB) in lipopolysaccharide-induced mononuclear macrophages, while its effect was significantly inhibited when exogenous recombinant IL-37 was administrated into cells.Accordingly, dysregulation of miR-657 contributes to the pathogenesis of GDM via IL-37/NF-κB signaling axis. K E Y W O R D S gestational diabetes mellitus, IL-37, inflammation, microRNA, NF-κB J Cell Physiol. 2019;234:7141-7148.wileyonlinelibrary.com/journal/jcp

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“…The assessment of the levels of interleukins in the human body can be used as a diagnostic indicator of the development or progression of many diseases (cancers [ 16 , 17 , 18 , 19 ], heart disease [ 20 , 21 , 22 ] and neurological disorders [ 23 , 24 , 25 ]) affecting contemporary society, including kidney diseases [ 26 , 27 , 28 , 29 , 30 ]. That is why it is extremely important to conduct further extensive scientific and clinical research to assess the biological functions of interleukins and their interactions with other cells of the body, which may lead to health deterioration.…”

Section: Introductionmentioning

confidence: 99%

Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

Mertowska

Mertowski

Smarz-Widelska³

et al. 2022

IJMS

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Each year, the number of patients who are diagnosed with kidney disease too late is increasing, which leads to permanent renal failure. This growing problem affects people of every age, sex and origin, and its full etiopathogenesis is not fully understood, although the involvement of genetic susceptibility, infections, immune disorders or high blood pressure is suggested. Difficulties in making a correct and quick diagnosis are caused by the lack of research on early molecular markers, as well as educational and preventive activities among the public, which leads to the late detection of kidney diseases. An important role in the homeostasis and disease progression, including kidney diseases, is attributed to interleukins, which perform several biological functions and interact with other cells and tissues of the body. The aim of this article was to systematize the knowledge about the biological functions performed by interleukins in humans and their involvement in kidney diseases development. In our work, we took into account the role of interleukins in acute and chronic kidney disease and kidney transplantation.

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Serum Interleukin‐37: a new player in Lupus Nephritis?

Abstract: IL-37 level is elevated in SLE patients in comparison to healthy controls and is correlated to high disease activity, mucocutaneous and renal involvement.

Cited by 22 publications

References 19 publications

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

Dysregulation of microRNA‐657 influences inflammatory response via targeting interleukin‐37 in gestational diabetes mellitus

Biological Role, Mechanism of Action and the Importance of Interleukins in Kidney Diseases

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