Serum ionized calcium, parathyroid hormone and related variables: effect of age and sex

Minisola, Salvatore; Pacitti, M. T.; Scarda, A.; Rosso, R.; Romagnoli, Elisabetta; Carnevale, Vincenzo; Scarnecchia, L.; Mazzuoli, G. F.

doi:10.1016/s0169-6009(08)80095-5

Cited by 48 publications

(29 citation statements)

References 28 publications

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“…It is noteworthy that we found mean values of bCTx in young men were higher than in young women of the same decade, while the opposite was observed later in life. Previous studies have shown a progressive decrease in bone formation markers with advancing age in males [6,16,19], which appears to be concomitant with the initial decrease in serum bCTx we found. The subsequent increase in bone resorption observed in the last decades might contribute to or exacerbate bone loss.…”

Section: Discussionsupporting

confidence: 81%

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Gender Differences in Serum Markers of Bone Resorption in Healthy Subjects and Patients with Disorders Affecting Bone

Minisola

Dionisi

Pacitti

et al. 2002

Osteoporosis International

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To assess how two different serum markers of bone resorption may reflect changes in bone turnover, we compared age- and sex-related changes in serum C-terminal telopeptide of type I collagen (betaCTx) and tartrate-resistant acid phosphatase activity (TRAP) in 136 healthy men and 184 normal women. Serum levels of the two markers were also assessed in several groups of patients of both sexes presenting with the most common metabolic and endocrine bone diseases: established osteoporosis (n = 77), primary hyperparathyroidism (n = 44), glucocorticoid excess (n = 17), chronic renal failure (n = 39), active Paget's disease of bone (n = 5), humoral hypercalcemia of malignancy (n = 3), osteomalacia (n = 3), hyperthyroidism (n = 10), post-surgical hypoparathyroidism (n = 10), acromegaly (active disease, n = 8) and Cushing's syndrome (n = 10). In men the regression of betaCTx with age showed an initial decrease in bone resorption followed by an increase thereafter, starting from the sixth decade of life. No age-related change in serum TRAP activity was observed. In women, by contrast, a slight but significant linear correlation of both serum betaCTx and TRAP with age (r = 0.223, p<0.003 and r = 0.333, p<0.0001, respectively) was found, the two markers being positively correlated (r = 0.238, p<0.002). In each class of patients the mean Z-scores of betaCTx were significantly higher than those of TRAP activity. Moreover, compared with normal subjects, serum betaCTx seems to be characterized by a superior sensitivity relative to TRAP measurement, at least in the disorders studied.

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Section: Discussionsupporting

confidence: 81%

“…All remaining parameters of skeletal metabolism, as well as measurements carried out in patients with endocrine disorders, were assayed according to standard procedures previously reported [15][16][17][18].…”

Section: Methodsmentioning

confidence: 99%

Gender Differences in Serum Markers of Bone Resorption in Healthy Subjects and Patients with Disorders Affecting Bone

Minisola

Dionisi

Pacitti

et al. 2002

Osteoporosis International

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“…For serum PTH, however, there is general agreement that there is an increase with age (17)(18)(19)(22)(23)(24). The cause of this is most likely related to vitamin D status.…”

Section: Discussionmentioning

confidence: 99%

Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromso study

Jorde

Sundsfjord

1999

European Journal of Endocrinology

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Objective: To study associations between serum ionised calcium, serum parathyroid hormone (PTH) and blood pressure. Design: A population based, cross-sectional study was used. Methods: Blood pressure, body mass index, serum ionised calcium and serum PTH were measured in 460 males and 486 females in the Tromsø study in 1994/1995. None were on medication for hypertension. The data were analysed with a multiple linear regression model. Results: When looking at subjects with serum ionised calcium <1.39 mmol/l, there was a significant negative association (P < 0.01) between serum ionised calcium and PTH. There was no association between blood pressure and serum ionised calcium. In both sexes there was a significant positive association between age and serum PTH (P < 0.01). For women, but not for men, there was a significant positive association between serum PTH and systolic and diastolic blood pressure (P < 0.01). Within each age group there was a difference in both systolic and diastolic blood pressure of 3-10 mm Hg between the upper and lower serum PTH halves of the female population. Females with hypertension had significantly higher serum PTH levels than the normotensive females (P < 0.01). Conclusion: Serum PTH is strongly and positively associated with blood pressure in women.

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“…Main parameters of skeletal metabolism were assayed according to standard procedures previously reported [11,12].…”

Section: Methodsmentioning

confidence: 99%

Clinical Validation of a New Immunoradiometric Assay for Intact Human Osteocalcin

et al. 1999

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The purpose of this study was to estimate clinical validity of a new available immunoradiometric assay for circulating intact human BGP (N-tact Osteo SP) by measuring this protein in a large number of normal subjects and patients with the most common metabolic bone diseases. One hundred normal subjects were studied in order to obtain our normal ranges (4.9 +/- 1.7 ng/ml). The mean values found in 28 patients with primary hyperparathyroidism (17.5 +/- 22.8 ng/ml, P < 0.001), 15 glucocorticoid-treated patients (1.9 +/- 1.5, P < 0. 001), 10 patients with hypoparathyroidism (1.5 +/- 0.7, P < 0.001), 9 with hyperthyroidism (8.3 +/- 3.8, P < 0.001), 8 with skeletal metastases (7.2 +/- 2.3, P < 0.001), and 4 with humoral hypercalcemia of malignancy (2.42 +/- 1.91, P < 0.005) were significantly different from mean values found in normal subjects. Mean decrease of serum osteocalcin T-score values was significantly greater when evaluated by N-tact Osteo SP assay in 15 steroid-treated patients (-1.4 +/- 1.0) and 19 primary hyperparathyroid (PHPT) patients (3.6 +/- 1.9), compared with the mean values obtained with the Elsa-Osteo assay (-0.67 +/- 1.2, P < 0. 002 and 4.3 +/- 2.8, P < 0.04, respectively). We found significant correlations between the global skeletal uptake of 99mTc-methylendiphosphonate and serum BGP levels assayed by both N-tact Osteo SP (P < 0.01) and Elsa-Ost-Nat assay (P < 0.05). Our results indicate that this new immunoradiometric assay for the intact human osteocalcin has the potential for good discrimination between normal subjects and patients with both low and high bone turnover. Furthermore, our findings emphasize the fact that, in the absence of available standardized commercial assays, one should rely on only one assay because different results are obtained by different assays under different clinical conditions.

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Serum ionized calcium, parathyroid hormone and related variables: effect of age and sex

Cited by 48 publications

References 28 publications

Gender Differences in Serum Markers of Bone Resorption in Healthy Subjects and Patients with Disorders Affecting Bone

Gender Differences in Serum Markers of Bone Resorption in Healthy Subjects and Patients with Disorders Affecting Bone

Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromso study

Clinical Validation of a New Immunoradiometric Assay for Intact Human Osteocalcin

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