Serum irisin levels in new-onset type 2 diabetes

Choi, Youn‐Hee; Kim, Mi-Kyung; Bae, Kwi Hyun; Seo, Hyun-Ae; Lee, Jeong Eon; Lee, Won-Kee; Kim, Jung‐Guk; Lee, Inkyu; Park, Keun-Gyu

doi:10.1016/j.diabres.2013.01.007

Cited by 383 publications

(375 citation statements)

References 28 publications

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“…However, it seems that irisin production by adipose tissue could be induced by some unknown obesity-related factor, as shown by the lack of correlation with other proteins secreted by the adipose tissue, e.g., leptin. This statement can be further illustrated by the lack of association between irisin and other adipose tissue-related proteins, such as adiponectin and TNFa, in the current and previous works (Choi et al, 2013;Stengel et al, 2012).…”

Section: Discusionmentioning

confidence: 71%

“…A limitation of the current study and previous is that a wide range of circulating irisin levels have been reported (Choi et al, 2013;Huh et al, 2012;Moreno-Navarrete et al, 2013;Stengel et al, 2012;Zhang et al, 2013), even through a same study (Moreno-Navarrete et al, 2013). This range of detection could be the result of variations on target epitopes among manufacturers, as no consensus exists on which part or parts of this membrane protein are soluble, nor does a consensus on the mechanism of irisin secretion exist (Roca-Rivada et al, 2013).…”

Section: Discusionmentioning

confidence: 74%

“…Surprisingly, a recent report has revealed a significant decrease in circulating irisin and adipose and muscle tissue gene expression levels in obesity, suggesting that irisin is inversely associated with different adiposity markers (Moreno-Navarrete et al, 2013). On the other hand, low circulating irisin levels were associated with chronic kidney disease (Wen et al, 2013), intrahepatic triglycerides content in obese adults with non alcoholic fatty liver disease (Zhang et al, 2013) and with type 2 diabetes (Choi et al, 2013;Liu et al, 2013). All together these reports highlight the need of further research to elucidate the true role of irisin in health and disease (Polyzos et al, 2013).…”

Section: Discusionmentioning

confidence: 97%

“…Whether irisin is regulated by insulin (Bostrom et al, 2012;Choi et al, 2013;Sanchis-Gomar et al, 2012) acting on fat and muscle cells or by another factor is at present unknown, and further work is necessary to completely understand the fine regulation of irisin secretion and its putative metabolic actions. However, the direct association observed between irisin and insulin together with the inverse correlation between irisin and ghrelin, a circulating orexigenic hormone with opposite pattern that of insulin, could suggest that irisin circulating levels in obesity may represent a compensatory response to the hyperglycemia but acquiring a reduced irisin sensitivity, such as insulin (Polonsky, 2000) and leptin (Montez et al, 2005) resistance, which is commonly present in obesity.…”

Section: Discusionmentioning

confidence: 99%

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Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

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Objective: The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.Methods: A group of 94 obese patients (50 men, 44 women; 49.4 6 9.4 years; BMI 35.6 6 4.5 kg/m 2 ) participated in a weight loss program following an 8-week hypocaloric diet (230% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 6 8.8 years; BMI 22.9 6 2.2 kg/m 2 ) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.Results: Irisin levels were higher in obese subjects (353.1 6 18.6 ng/mL) than in those of normal-weight (198.4 6 7.8 ng/mL; P 0.001) and were also higher in men (340.9 6 20 ng/mL) than in women (267.6 6 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.Conclusions: Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198-207, 2014.

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Section: Discusionmentioning

confidence: 71%

Section: Discusionmentioning

confidence: 74%

Section: Discusionmentioning

confidence: 97%

Section: Discusionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

View full text Add to dashboard Cite

show abstract

“…2016), others have shown decreased irisin in type 2 diabetic patients (Choi et al. 2013; Moreno‐Navarrete et al. 2013; Hu et al.…”

Section: Introductionmentioning

confidence: 99%

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

et al. 2017

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FNDC5/irisin, has recently been identified as a novel protein that stimulates the “browning” of white adipose by inducing thermogenesis via increased uncoupling protein 1 (UCP1). We tested the hypothesis that high fat diet‐induced prediabetic mice would exhibit increased FNDC5 and this effect would be attenuated by chronic exercise. C57BL/6 mice were randomized into three groups for the 4 week intervention: Standard diet (Std, n = 12), High fat diet (HF, n = 14), or High fat diet and free access to a running wheel (HFEX, n = 14). Body weight, glucose, insulin, and the homeostatic model assessment of insulin resistance (HOMA‐IR) were greater in HF compared to Std and HFEX after the 4 week intervention. In support of our hypothesis, FNDC5 was higher in HF in both skeletal muscle and adipose compared to Std and was lower in adipose only in HFEX compared to HF mice. Following the same pattern, PGC‐1α was significantly higher in HF compared to Std in skeletal muscle and significantly lower in HFEX compared to HF in adipose. UCP1 was significantly lower in HFEX versus Std (in skeletal muscle) and versus HF (in adipose). HOMA‐IR was significantly correlated with FNDC5 protein levels in adipose. Increased FNDC5 in adipose and skeletal muscle may be a compensatory mechanism to offset high fat diet‐induced weight gain and insulin resistance by increasing energy expenditure.

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Effects of irisin on the dysfunction of blood–brain barrier in rats after focal cerebral ischemia/reperfusion

Guo

Jin

et al. 2019

Brain and Behavior

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Objective To investigate whether irisin could protect against blood–brain barrier (BBB) dysfunction following focal cerebral ischemia/reperfusion in rats. Methods and Materials Seventy‐two adult male Sprague Dawley rats weighing 280–320 g were randomly divided into three groups: sham operation group (S), focal cerebral ischemia/reperfusion group (FC), and irisin group (IR). Focal cerebral ischemia was induced by improved thread occlusion of right middle cerebral artery (MCAO) for 2 hr followed by reperfusion for 24 hr in rats. After 24 hr of reperfusion, the neurological evaluation was performed by the method of Longa's score. The histopathological changes were observed by HE staining. The brain water content was determined by detecting the wet weight and dry weight. The BBB permeability was assessed by fluorescence spectrophotometer and fluorescence microscopy for Evans blue (EB) extravasation. The activity and expression of matrix metalloproteinase‐9 (MMP‐9) in different groups were detected by immunohistochemical staining, Western blot, and gel gelatin zymography. Results After MCAO, the neurological deficit scores, the infarct volume, the brain water content, and the EB content were higher in the FC group than those in the S group (p < .05). While after irisin treatment, these indicators mentioned above were lower than those in the IR group (p < .05). Moreover, the protein expression of MMP‐9 in the cortex increased significantly after MCAO, while irisin treatment could decrease the protein expression of MMP‐9 in the cortex (p < .05). Conclusion Our data suggest that irisin can attenuate brain damage both morphologically and functionally and protect BBB from disruption after focal cerebral ischemia/reperfusion, which is highly associated with the inhibition of the expression and activity of MMP‐9 in the brain tissue.

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Serum irisin levels in new-onset type 2 diabetes

Cited by 383 publications

References 28 publications

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

Effects of irisin on the dysfunction of blood–brain barrier in rats after focal cerebral ischemia/reperfusion

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