Serum Lactic Acid Dehydrogenase and Isoenzymes During Pregnancy and Labor

Makkonen, M.; Penttilä, Ilkka; Castrén, Olli

doi:10.3109/00016348009154622

Cited by 14 publications

(14 citation statements)

References 36 publications

(26 reference statements)

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“…Lactate dehydrogenase is an enzyme found in several tissues, which acts on the anaerobic metabolism of carbohydrates and catalyzes from pyruvate to lactate. Serum LDH is elevated at the end of pregnancy and at delivery (Makkonen et al 1980). However, no differences were found between the pregnant group (9.70 ± 2.42 mmol/L) and non-pregnant group (9.31 ± 2.66 mmol/L) when blood lactate concentrations were analyzed at the respective AT.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of anaerobic threshold in non-pregnant and pregnant rats

Netto

Macedo

Gallego

et al. 2017

An. Acad. Bras. Ciênc.

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Several studies present different methodologies and results about intensity exercise, and many of them are performed in male rats. However, the impact of different type, intensity, frequency and duration of exercise on female rats needs more investigation. From the analysis of blood lactate concentration during lactate minimum test (LacMin) in the swimming exercise, the anaerobic threshold (AT) was identified, which parameter is defined as the transition point between aerobic and anaerobic metabolism. LacMin test is considered a good indicator of aerobic conditioning and has been used in prescription of training in different exercise modalities. However, there is no evidence of LacMin test in female rats. The objective was to determine AT in non-pregnant and pregnant Wistar rats. The LacMin test was performed and AT defined for mild exercise intensity was from a load equivalent to 1% of body weight (bw), moderate exercise as carrying 4% bw and severe intensity as carrying 7% bw. In pregnant rats, the AT was reached at a lower loading from 5.0% to 5.5% bw, while in non-pregnant the load was from 5.5% to 6.0% bw. Thus, this study was effective to identify exercise intensities in pregnant and non-pregnant rats using anaerobic threshold by LacMin test.

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Section: Discussionmentioning

confidence: 92%

Evaluation of anaerobic threshold in non-pregnant and pregnant rats

Netto

Macedo

Gallego

et al. 2017

An. Acad. Bras. Ciênc.

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“…During normal uncomplicated pregnancy, reported LDH values all remained below the normal cut-off values [25-28]. …”

Section: Resultsmentioning

confidence: 99%

Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review

Han

Lotgerink

Gzirí

et al. 2012

BMC Med

113

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BackgroundRecent insights provide support for the treatment of cancer during pregnancy, a coincidence that poses both mother and fetus at risk. Our aim was to critically review studies on the physiologic variations during pregnancy, the most common tumor markers used in diagnosis and follow-up of gynecological cancers.MethodsWe conducted a systematic review of six tumor markers during normal pregnancy: carbohydrate antigen (CA) 15-3 (breast cancer); squamous cell carcinoma antigen (cervical cancer); and CA 125, anti-Müllerian hormone, inhibin B and lactate dehydrogenase (ovarian cancer).ResultsFor CA 15-3, 3.3% to 20.0% of all measurements were above the cut-off (maximum 56 U/mL in the third trimester). Squamous cell carcinoma antigen values were above cut-off in 3.1% and 10.5% of the measurements (maximum 4.3 µg/L in the third trimester). Up to 35% of CA 125 levels were above cut-off: levels were highest in the first trimester, with a maximum value up to 550 U/mL. Inhibin B, anti-Müllerian hormone and lactate dehydrogenase levels were not elevated in maternal serum during normal pregnancy.ConclusionDuring normal pregnancy, tumor markers including CA 15.3, squamous cell carcinoma antigen and CA 125 can be elevated; inhibin B, anti-Müllerian hormone and lactate dehydrogenase levels remain below normal cut-off values. Knowledge of physiological variations during pregnancy can be clinically important when managing gynecological cancers in pregnant patients.

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“…; Makkonen et al . ), and it has been suggested from plasma that changes in the profile of LDH isoforms may influence cervical dilatation (Neal et al . ).…”

Section: Introductionmentioning

confidence: 99%

Insights from physiology into myometrial function and dysfunction

Wray

2015

Experimental Physiology

104

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After training in physiology at UCL, I took up a lectureship in Liverpool in 1990 and am now getting my long-service award! I enjoy exploring myometrial physiology and its interaction with metabolism, as well as thinking about how our science may be of relevance to women in labour. I also spend time mentoring female physiologists and serve as Director of Athena SWAN for my university. I am proud to have co-edited The Physiological Society's book celebrating the centenary of women being elected to the Society, and to have been a Joan Mott lecturer. New Findings r What is the topic of this review?I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. r What advances does it highlight?Physiological studies have recently shed light on the myometrium in twin pregnancies, but there have been no 'omic' approaches. In contrast, studies of preterm delivery using newer approaches are generating new research avenues, whereas traditional approaches have not flourished. Finally, I describe significant advances in understanding of 'slow-to-progress' labours, achieved using physiological and clinical approaches. Advances in molecular, genetic and 'omic' technologies are fuelling the thirst for better understanding of the uterus and application of this information to problems in pregnancy and labour. Progress has, however, been limited while we still have an incomplete understanding of some of the basic physiology of uterine smooth muscle (myometrium). In this review and opinion piece, I explore some of the fascinating findings from selected recent studies and see how these may provide new avenues for physiological and clinical research. It is also the case, however, that there is still limited mechanistic understanding about physiological and pathophysiological processes in the myometrium. This lack of understanding limits the usefulness of some findings from genomic and allied studies. By focusing on some key recent findings and relating these to two important clinical problems in childbirth that involve myometrial activity, namely preterm delivery and difficult labours, the interplay between our physiological knowledge and the information provided by newer technologies is explored. My opinion is that physiology has provided much more new mechanistic insight into difficult births and that the newer

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Serum Lactic Acid Dehydrogenase and Isoenzymes During Pregnancy and Labor

Cited by 14 publications

References 36 publications

Evaluation of anaerobic threshold in non-pregnant and pregnant rats

Evaluation of anaerobic threshold in non-pregnant and pregnant rats

Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review

Insights from physiology into myometrial function and dysfunction

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