Serum Lactic Dehydrogenase in the Differential Diagnosis of Acute Hepatocellular Injury

Cassidy, William M.; Reynolds, Telfer B.

doi:10.1097/00004836-199409000-00008

Cited by 143 publications

(83 citation statements)

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“…LDH, a cytoplasmic marker enzyme catalyses the readily reversible reaction involving oxidation of lactate to pyruvate and serves as a biochemical indicator of organ dysfunction, differentiates normal tissues from their damaged counterparts and spot various stages of tissue development. 66,67 In the present investigation, damage to stomach and lung tissues by DMBA is reflected by a substantial decrease in the activity of LDH showing suppressed lactate metabolism. Furthermore, LDH is believed to vary according to the metabolic necessity of each tissue and alteration in LDH levels have been observed during development under changing biological conditions and in response to pathological processes.…”

Section: Articlesupporting

confidence: 46%

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Kaur

Arora

et al. 2017

J Xenobiotics

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Abstract3β, hydroxy-lup-20(29)-en-28-oic acid (Betulinic acid), a pentacyclic lupane-type triterpene has diverse pharmacological functions both in vitro and in vivo. The present study focuses its protective effect on polycyclic aromatic hydrocarbon (7,12-Dimethylbenz(a)anthracene or DMBA) induced alterations in membrane bound ATPases, detoxification enzymes and antioxidant enzymes in stomach and lungs of female Sprague Dawley rats. Healthy female Sprague Dawley rats were randomly assorted into six groups and the treatments were given orally for 7 weeks on alternate days. It was observed that betulinic acid facilitated the downregulation of elevated membrane bound ATPases (Na + /K + -ATPase, Ca 2+ -ATPase and Mg 2+ -ATPase) in DMBA administered rats. Likewise, the detoxification enzymes as well as antioxidant enzymes were modulated to normalcy in rats. Overall, betulinic acid was seen to be effective modulator of DMBA induced alterations in biochemical parameters.

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Section: Articlesupporting

confidence: 46%

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Kaur

Arora

et al. 2017

J Xenobiotics

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“…GSH was estimated by the method of [5]. Briefly, 0.5 ml of tissue homogenate was precipitated with 2 ml of 5% TCA.…”

Section: Reduced Glutathione (Gsh)mentioning

confidence: 99%

“…Because free radicals and reactive oxygen species play a central role in liver diseases pathology and progression, dietary antioxidants have been proposed as therapeutic agents to counteract liver damage [4]. Additionally, recent studies have suggested that natural antioxidants in complex mixtures ingested with the diet are more efficacious than pure compounds in preventing oxidative stress-related pathologies due to particular interactions and synergism [5,6]. It is evident that there is an increasing demand to evaluate the antioxidant properties of direct plant extract [7].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Mediated Defense Role of Ecliptaalba Herbal Extract Against Ccl4 Inducedtoxic Hepatitis

Priya¹

2018

Int J Curr Pharm Sci

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Objective: The present study focuses on the antioxidant mediated the protective effect of a popular medicinal herb Ecliptaalba against CCl4 induced oxidative stress in the liver of rats.Methods: Rats divided into four groups were administered with CCl4 andCCl4 along with methanol extract of leaves of Eclipta herb (200 and 400 mg/kg b. wt) for three weeks. At the end of treatment, rats were anaesthetized and blood samples were collected for serum separation. Biochemical analysis such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total bilirubin (TB) was done in serum. Liver tissue was used for glutathione (GSH), lipid peroxidation (LPO), glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) analysis. CCl4 administration caused significant elevation of the serum enzymes and total bilirubin content.Results: Antioxidant enzymes were drastically inhibited with a significant reduction of glutathione and increased lipid peroxidation in CCl4 treated rats. Ecliptaalba extracts administrated rats, however, did not show much changes in marker enzyme level. Antioxidant enzyme status was also not affected and found nearer to the control levels. Increased gluatathione level and reduced lipid peroxidation were also evident in Eclipta alba treated rats. Conclusion:The findings show that Eclipta alba extract offers better protection against the free radical toxicity of CCl4.

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“…Transaminases and LDH levels reach their peak 1-3 days after the acute event and return to normal limits within 7-10 days if the patient's hemodynamics recover (19,56,57). In ACLI, an early and rapid increase of LDH levels in parallel with transaminase levels, a ratio of ALT to LDH <1.5, and a decrease in ALT levels by more than 50% within 72 h are characteristic findings that can be useful in the differential diagnosis of acute viral, alcoholic, or drug-induced hepatitis (29,58,59). Other laboratory findings are mild elevations of serum bilirubin and AP levels and prolongation of prothrombin time (11,19,29).…”

Section: Clinical Findings and Implications Of The Laboratory Changesmentioning

confidence: 99%

How to interpret liver function tests in heart failure patients?

Cagli

Başar²,

Tok³

et al. 2020

Turk J Gastroenterol

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Cardiac hepatopathy has generally been used to describe any liver damage caused by cardiac disorders in the absence of other possible causes of liver damage. Although there is no consensus on the terminology used, cardiac hepatopathy can be examined as congestive hepatopathy (CH) and acute cardiogenic liver injury (ACLI). CH is caused by passive venous congestion of the liver that generally occurs in the setting of chronic cardiac conditions such as chronic HF, constrictive pericarditis, tricuspid regurgitation, or right-sided heart failure (HF) of any cause, and ACLI is most commonly associated with acute cardiocirculatory failure resulting from acute myocardial infarction, acute decompensated HF, or myocarditis. Histologically, CH is characterized by sinusoidal dilation, replacement of hepatocytes with red blood cells extravasating from the sinusoids, and necrosis/apoptosis of zone 3 of the Rappaport acinus, and it could progress to cirrhosis in advanced cases. In ACLI, however, massive necrosis of zone 3 is the main histological finding. Primary laboratory findings of CH are elevated serum cholestasis markers including bilirubin, alkaline phosphatase, and γ-glutamyl-transpeptidase levels, whereas those of ACLI are a striking elevation in transaminase and lactate dehydrogenase levels. Both CH and ACLI have a prognostic value for identifying cardiovascular events and mortality and have some special implications in the management of patients undergoing ventricular assist device implantation or cardiac transplantation. There is no specific treatment for CH or ACLI other than treatment of the underlying cardiac disorder.

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Serum Lactic Dehydrogenase in the Differential Diagnosis of Acute Hepatocellular Injury

Cited by 143 publications

References 0 publications

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Effect of 3β, hydroxy-lup-20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats

Antioxidant Mediated Defense Role of Ecliptaalba Herbal Extract Against Ccl4 Inducedtoxic Hepatitis

How to interpret liver function tests in heart failure patients?

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