Serum Levels of Anti-Hepatitis B Surface Antibody Among Vaccinated Population Aged 1 to 18 Years in Ahvaz City Southwest of Iran

Norouzirad, Reza; Shakurnia, Abdolhussein; Assarehzadegan, Mohammad-Ali; Serajian, Amirarsalan; Khabazkhoob, Mehdi

doi:10.5812/hepatmon.13625

Cited by 33 publications

(39 citation statements)

References 24 publications

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“…This is in accordance with previous studies of vaccinees who reported that, the antibody levels decrease with time, but breakthrough infections in vaccinated people are rare [West and Calandra, 1996;Banatvala and Van Damme, 2003]. Norouzirad et al [2014] found a significant negative correlation between anti-HBs levels and age (r ¼ À0.220, P ¼ 0.0001).…”

Section: Discussionsupporting

confidence: 92%

The efficacy of hepatitis B vaccination program in upper Egypt: Flow cytometry and the evaluation of long term immunogenicity

Makhlouf

Farghaly

Zaky

et al. 2016

Journal of Medical Virology

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Anti-HBs levels wanes with time. Many studies discussed the B cell response to HBV vaccine. However, the data about memory T cell response are limited. To evaluate the efficacy of hepatitis B vaccine via evaluating anti-HBs levels and HBsAg specific memory T-lymphocytes through descriptive study. The study was conducted in a tertiary care setting. This study included 440 vaccinated persons during infancy. Group I: 6 to less than 10 years old; Group II: 10 to less than 14 years old; Group III: 14 to less than 17 years old; Group IV: 17 years old. The serum samples were screened for HBV markers. Cytokines secretion by HBsAg-specific memory CD45RO(+) CD4(+) T cells was measured after in vitro culture using flow cytometry. The mean titer of anti-HBs was higher in group I in comparison to others (P-value = 0.000 for each). IFN-γ and IL-4 secreted by memory CD4(+) T cells were positive in all with anti-HBs>100 mIU/ml, while positive in 87% and 75% of participants with anti-HBs <10 mIU/ml and positive in 73% and 32% of participants with absent anti-HBs. The percentage of cells secreting IFN-γ and those secreting IL-4 were higher among participants with serum anti-HBs >100 mIU/ml than those having <10 mIU/ml or absent (P < 0.001 for each). Anti-HBs positivity decreased with time since childhood vaccination. Breakthrough infections are rare in vaccinated persons. Hepatitis-B vaccine is efficient in controlling HBV infection. Flow cytometry is a useful tool to assess the long term persistence of T cell memory after childhood vaccination. J. Med. Virol. 88:1567-1575, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 92%

The efficacy of hepatitis B vaccination program in upper Egypt: Flow cytometry and the evaluation of long term immunogenicity

Makhlouf

Farghaly

Zaky

et al. 2016

Journal of Medical Virology

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“…7 Five (6.8%) vaccinated medical students were anti-HBs negative or had titres < 10 mIU/mL, and thus can be considered non-responders to vaccination. 25 Alternatively these students could have responded initially and their anti-HBs levels could have declined with age, 25 but this wasn't evaluated in our study. In our study, anti-HBs were detected in 42.9% of subjects "vaccinated with single dose" ( Table 3).…”

Section: Discussionmentioning

confidence: 91%

Hepatitis B surface antibodies in medical students from a public university in Puebla, Mexico

Cárdenas-Perea

Gómez-Conde

Santos‐López

et al. 2016

Human Vaccines & Immunotherapeutics

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Although preventable with vaccination, Hepatitis B virus (HBV) infection is a major health concern, with »400 million people at risk of developing the chronic form of the disease worldwide. The anti-HBV vaccine consists of a recombinant HBV surface antigen (HBsAg), which induces specific anti-HBs antibodies and confers 95% protection for >20 y. The aim of the present study was to analyze the response to HBV vaccination by measuring anti-HBs antibodies in serum samples from medical students of a public university in Puebla, Mexico. HBV infection markers HBsAg and anti-HBs, were also determined. A total of 201 students were included and vaccination coverage was found at 54%. Overall seropositivity for HBsAg, anti-HBc and anti-HBs determined by ELISA was 0.5%, 1.0% and 47%, respectively. Protective levels of anti-HBs >10 mIU/mL were found in 93.2% of subjects vaccinated with 2 or 3 doses and in 40% of those vaccinated with a single dose; while only 4.8% of unvaccinated subjects were anti-HBs positive. The response to the HBV vaccine was different in each participant, despite similar vaccination scheme. A history of blood transfusion/organ transplant or more than 2 sexual partners was significantly associated with anti-HBc positivity, OR D 399 (p D 0.010) and OR D 19.9 (p D 0.044), respectively. HBV immunization coverage was low in our sample compared with reports from countries with similar HBV prevalence, but anti-HBs in vaccinated individuals were in the expected range. It is important to promote HBV vaccination and awareness among medical students, due to their exposure risk.

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“…The anti-HBs titer correlated to the frequency of IFN-γ-producing HBs-specific T cells. Reports show that HBs-specific T cell and antibody responses did not differ between vaccines and HBV-recovered patients3738. This finding suggests that greater levels of antibody production would lead to enhanced immunity, and that HCV infection may directly or indirectly influence HBV surface antibody production.…”

Section: Discussionmentioning

confidence: 92%

HBV/HCV dual infection impacts viral load, antibody response, and cytokine expression differently from HBV or HCV single infection

Chen

Zhang

Wen

et al. 2016

Sci Rep

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Hepatitis B virus/hepatitis C virus (HBV/HCV) dual infection is common among high-risk individuals. To characterize the virological and immunological features of patients with HBV/HCV dual infection, we enrolled 1,049 individuals who have been identified as injection drug users. Patients were divided into single and dual infection groups according to the serological markers. We found the average HCV RNA level was significantly lower; however, HBV viral load was significantly higher in HBV/HCV dual-infected patients (n = 42) comparing HCV single infection (n = 340) or HBV single infection (n = 136). The level of anti-HBs in patients who experienced spontaneous HBV clearance was higher than that in HCV single-infected patients with HBV spontaneous clearance. The level of anti-HCV E2 in HBV/HCV dual infection was lower than that detected in HCV single infection. Serum levels of IL-6, IL-8, and TNF-α were significantly lower in HBV/HCV dual-infected patients than in patients infected with HBV or HCV alone. Taken together, two viral replications are imbalanced in dual infected patients. The anti-HBs and anti-HCV E2 antibody production were impaired and proinflammatory IL-6, IL-8, and TNF-α also downregulated due to dual infection. These findings will help further understanding the pathogenesis of HBV/HCV dual infection.

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Serum Levels of Anti-Hepatitis B Surface Antibody Among Vaccinated Population Aged 1 to 18 Years in Ahvaz City Southwest of Iran

Cited by 33 publications

References 24 publications

The efficacy of hepatitis B vaccination program in upper Egypt: Flow cytometry and the evaluation of long term immunogenicity

The efficacy of hepatitis B vaccination program in upper Egypt: Flow cytometry and the evaluation of long term immunogenicity

Hepatitis B surface antibodies in medical students from a public university in Puebla, Mexico

HBV/HCV dual infection impacts viral load, antibody response, and cytokine expression differently from HBV or HCV single infection

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