Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes

Miura, Junnosuke; Yamagishi, Sho Ichi; Uchigata, Yasuko; Takeuchi, Masayoshi; Yamamoto, Hiroshi; Makita, Zenji; Iwamoto, Yasuhiko

doi:10.1016/s1056-8727(02)00183-6

Cited by 133 publications

(99 citation statements)

References 25 publications

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“…In our study, as in previous reports [13,14,20], patients with microalbuminuria had higher MDA, pentosidine and AGE serum levels than patients without microalbuminuria, even in conditions of normal renal function, and these factors may play a role in endothelial dysfunction. On the other hand, type 2 diabetic patients with macrovascular complications, and peripheral artery VIF, variance inflation factor disease in particular, had high serum levels of MDA, pentosidine and AGE [37].…”

Section: Discussionsupporting

confidence: 90%

“…In this setting, several studies have examined the possible relationship between microalbuminuria and AGE in type 1 diabetic patients [12][13][14]; a few have focused on type 2 diabetic patients [15][16][17]. In type 1 diabetes, serum AGE levels correlate with the stage of nephropathy [14], even suggesting a pathogenic role for them in the progression of early diabetic nephropathy [13].…”

mentioning

confidence: 99%

“…In type 1 diabetes, serum AGE levels correlate with the stage of nephropathy [14], even suggesting a pathogenic role for them in the progression of early diabetic nephropathy [13]. Increases in skin collagen-linked pentosidine levels and AGE have also been correlated with AER [12].…”

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confidence: 99%

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Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

et al. 2009

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Aims/hypothesis This study examined the relationship, if any, between glucose-induced oxidative stress, antioxidant status and microalbuminuria in patients with type 2 diabetes. Methods The study involved 99 consecutive type 2 diabetic patients (57 men, 42 women). Patients with persistent microalbuminuria were identified and the following variables evaluated: fasting plasma glucose, HbA 1c , malonyldialdehyde (MDA), pentosidine, AGE, the total radical-trapping antioxidant parameter (TRAP), vitamin E, creatinine, estimated GFR and lipid profile. Results Patients were divided into two groups, i.e. 37 individuals without microalbuminuria (AER <20 μg/min) and 62 with microalbuminuria (AER ≥20 μg/min). The following variables were significantly higher in patients with microalbuminuria than in those without microalbuminuria (mean ± SD): fasting plasma glucose 9.41±2.88 vs 8.19±1.93 mmol/l, p<0.05; HbA 1c 7.97±1.51 vs 7.39± 1.03%, p<0.05; MDA 1.18±0.35 vs 1.02±0.29 µmol/l, p< 0.05; pentosidine 98.5±24.6 vs 82.9±20.9 pmol/ml, p< 0.005; and AGE 13.2±4.8 vs 10.6±3.8 µg/mg protein, p< 0.01. However, vitamin E and TRAP did not differ between the two groups. Serum creatinine values and estimated GFR were similar in the two groups. Only in patients with microalbuminuria were significant linear correlations seen between AER and both oxidation (HbA 1c r=0.33, p<0.01; MDA r=0.59, p<0.001; pentosidine r=0.48, p<0.001; and AGE r=0.44, p<0.001) and antioxidation variables (vitamin E r=−0.55, p<0.001; TRAP r=−0.49, p<0.001). Considering all variables together, multiple regression revealed a correlation between microalbuminuria and vitamin E, TRAP, HbA 1c and MDA, but not pentosidine or AGE. Conclusions/interpretation Our data suggest that microalbuminuria in type 2 diabetic patients might be promoted by an insufficient counter-regulation of the antioxidant system in the event of increased glyco-oxidation/glycation.

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Section: Discussionsupporting

confidence: 90%

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Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

et al. 2009

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“…Possibly as a consequence of this, increased serum AGE (s-AGE) concentrations are associated with increased plasma triglycerides and LDL concentrations in children and adolescents with type 1 diabetes (13). Increased serum concentrations of AGE may in addition contribute to the development of vascular complications by inducing endothelial dysfunction (14) and retinopathy (15,16). Although irreversible glycation should be increased by prolonged hyperglycaemic exposure, s-AGE concentrations were not increased in children and adolescents with long durations of type 1 diabetes (13,17).…”

Section: Introductionmentioning

confidence: 99%

Plasma adiponectin and serum advanced glycated end-products increase and plasma lipid concentrations decrease with increasing duration of type 2 diabetes

Gottsäter

Szelag²,

Kangro³

et al. 2004

European Journal of Endocrinology

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Objective: To prospectively follow the concentrations of plasma adiponectin (p-adiponectin) and serum advanced glycation end-products (s-AGE) in relation to plasma lipids and retinopathy over 3 years in type 2 diabetic patients. Design and methods: P-adiponectin, s-AGE, plasma lipids and diabetic retinopathy were prospectively evaluated in 61 type 2 diabetic patients at baseline and at follow up 3 years later. Results: Mean p-adiponectin (from 8.84^5.14 to 11.05^6.16 mg/ml; P ¼ 0.006) and s-AGE (from 637^242 to 781^173 ng/ml; P , 0.0001) concentrations had increased at follow up. In addition, HbA1c (7.7^1.7 to 7.4^1.4%; P ¼ 0.0045) and fasting C-peptide (1.00^0.38 to 0.81^0.35 nM; P ¼ 0.019) had decreased and all lipid variables had significantly improved at follow up. P-adiponectin correlated inversely with fasting C-peptide (r s ¼ 20.273; P ¼ 0.045) and low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio (r s ¼ 20.362; P ¼ 0.011), and directly with plasma HDL cholesterol (r s ¼ 0.381; P ¼ 0.005) at follow up. Analysis of variance with adiponectin and s-AGE as dependent variables and fasting C-peptide, plasma HDL and plasma LDL cholesterol as covariates demonstrated that the increase in s-AGE was independent (P ¼ 0.001) and the increase in p-adiponectin dependent on covariate changes (P ¼ 0.862). There was a slight correlation between s-AGE at baseline versus the degree of retinopathy at follow up (r s ¼ 0.281; P ¼ 0.0499).

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“…Essa lisina glicada foi detectada em proteínas teciduais como as do cristalino (DUNN et al, 1989), no colágeno da pele (DUNN et al, 1991) e na urina (WADMAN et al, 1975). Também, foi relatado que seus níveis estão aumentados no sangue e no colágeno da pele de pacientes com diabetes, comparado com indivíduos saudáveis (DYER et al, 1993;MIURA et al, 2003) 3) A interação entre os AGEs e seu receptor ativa sinais de transdução e induz resposta inflamatória. A interação AGE-RAGE (recepetor de AGE) ativa o fator nuclear-B, aumentando a transcrição para citocinas pró-inflamatórias (IL-1, IL-6), TNF-α, e moléculas de adesão como endotelina -1, VCAM-1 e selectina E (figura 6), e consequentemente, promove o stress oxidativo, trombogênese, inflamação vascular e angiogênese, eventos diretamente relacionados a complicações macro e microvasculares do diabetes (HUTTUNEN et al, 1999;HUANG et al, 2001;WAUTIER et al, 2001;HARJA et al, 2008;SEMBA et al, 2010).…”

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Formação de produtos da reação de Maillard em carne bovina (<i>Semimembranosus</i>) submetida a diferentes técnicas de cocção

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Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes

Cited by 133 publications

References 25 publications

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients

Plasma adiponectin and serum advanced glycated end-products increase and plasma lipid concentrations decrease with increasing duration of type 2 diabetes

Formação de produtos da reação de Maillard em carne bovina (<i>Semimembranosus</i>) submetida a diferentes técnicas de cocção

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