Serum levels of transforming growth factor β1 and C-reactive protein as possible markers of intra uterine insemination outcome

Şahin, Ayşe; Üstün, Yaprak Engin; Tokmak, Aytekin; Şahin, Hasan; Erkaya, Salım; Özgü-Erdinç, A. Seval

doi:10.1684/ecn.2018.0418

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…11 Data from women with polycystic ovary syndrome (PCOS) suggest that systemic low-grade inflammation, as measured by CRP, may contribute to ovulatory disorders or subfertility, even independently of obesity. 12,13,14 Higher serum CRP levels were reported among fertility treatment patients with unsuccessful intrauterine insemination cycles 15 or euploid pregnancy loss. 16 Circulating CRP levels were higher in women with unexplained infertility compared with fertile women and also higher in women with diminished ovarian reserve compared with women with normal ovarian reserve.…”

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confidence: 99%

Inflammation and Conception in a Prospective Time-to-Pregnancy Cohort

et al. 2022

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Background: Inflammation may contribute to subfertility but this has not been well-explored in large prospective cohort studies. Methods: We conducted a prospective 12-month cohort study of time to pregnancy in North Carolina, the Time to Conceive study (2010)(2011)(2012)(2013)(2014)(2015)(2016). Participants were 30-44 years old, without a history of infertility (N = 727). We analyzed blood samples with a high sensitivity assay for C-reactive protein (CRP). Women reported their weight, height, and other covariates. We natural log-transformed CRP and examined it (1) linearly, after exploration using restricted cubic splines and (2) in categories based on American Heart Association criteria. We estimated fecundability ratios (FRs) with log-binomial discrete-time-to-pregnancy models. Separate models included an interaction term with body mass index (BMI). Results: The adjusted estimated FR per natural log-unit increase in CRP level was 0.97 (confidence interval [CI] = 0.91, 1.0). The FR (CI) for high CRP (>10 mg/L) compared with low CRP (<1 mg/L) was 0.78 (0.52, 1.2). Compared with normal-weight women with low CRP, women with obesity and high CRP had lower estimated fecundability, but the confidence interval was wide (FR = 0.63; CI = 0.35, 1.1). There was no pattern in the estimated fecundability across levels of CRP within categories of BMI. Conclusions: There was no evidence of an association between CRP and fecundability either alone or within levels of BMI. Further studies of CRP and fecundability should include higher levels of CRP and additional markers of inflammation.

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confidence: 99%

Inflammation and Conception in a Prospective Time-to-Pregnancy Cohort

et al. 2022

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“…Both groups were similar in regards to BMI, infertility duration, and infertility diagnosis. However, the group that achieved pregnancy was significantly younger on average (25.5 ± 5.4 vs. 29.2 ± 5.4 years, P =.012), which was not adjusted for in the analysis ( 21 ). Another similar study compared the hs-CRP levels 2 and 8 days after IUI and found no difference between pregnant and non-pregnant patients, but this study was limited by its small sample size (n = 42), and only 8 patients became pregnant ( 22 ).…”

Section: Discussionmentioning

confidence: 98%

High-sensitivity C-reactive protein levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine insemination in a multicenter trial

et al. 2022

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“…Available data support the association between high serum CRP values before embryo implantation and ART failure [53,61]. However, many of the reported studies did not adjust for confounding factors, including age [62], thus erasing concerns about the real effect of inflammaging on reproductive performance [53,[61][62][63][64][65][66][67].…”

Section: In Vitro Fertilizationmentioning

confidence: 99%

Role of Inflammaging on the Reproductive Function and Pregnancy

Zavatta

Parisi

Mandò

et al. 2022

Clinic Rev Allerg Immunol

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During female lifetime and pregnancy, inflammation and cellular senescence are implicated in physiological processes, from ovulation and menstruation, to placental homeostasis and delivery. Several lifestyles, nutritional, and environmental insults, as well as long-lasting pregestational inflammatory diseases may lead to detrimental effects in promoting and sustaining a chronic excessive inflammatory response and inflammaging, which finally contribute to the decay of fertility and pregnancy outcome, with a negative effect on placental function, fetal development, and future health risk profile in the offspring. Maladaptation to pregnancy and obstetric disease may in turn increase maternal inflammaging in a feedback loop, speeding up aging processes and outbreak of chronic diseases. Maternal inflammaging may also impact, through transgenerational effects, on future adult health. Hence, efficacious interventions should be implemented by physicians and healthcare professionals involved in prevention activities to reduce the modifiable factors contributing to the inflammaging process in order to improve public health.

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Serum levels of transforming growth factor β1 and C-reactive protein as possible markers of intra uterine insemination outcome

Cited by 4 publications

References 27 publications

Inflammation and Conception in a Prospective Time-to-Pregnancy Cohort

Inflammation and Conception in a Prospective Time-to-Pregnancy Cohort

High-sensitivity C-reactive protein levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine insemination in a multicenter trial

Role of Inflammaging on the Reproductive Function and Pregnancy

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