Serum lipid levels and bone mineral density in Greek postmenopausal women

Pliatsika, Paraskevi; Antoniou, Aris; Alexandrou, Andreas; Panoulis, Constantinos; Kouskouni, Evangelia; Augoulea, Areti; Dendrinos, S.; Aravantinos, Leon; Creatsa, Maria; Lambrinoudaki, Ιrene

doi:10.3109/09513590.2011.650766

Cited by 21 publications

(20 citation statements)

References 33 publications

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“…Many studies do not support strong association between lipids' concentrations and bone mass measurements [38]. In this study, we report also a weak relationship between lipid levels and BMD in SCI population.…”

Section: Discussioncontrasting

confidence: 70%

Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?

Sabour

Javidan

Latifi

et al. 2014

Journal of Osteoporosis

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Purpose. The association between serum lipids and bone mineral density (BMD) has been investigated previously but, up to now, these relationships have not yet been described in spinal cord injury (SCI). We tried to assess the correlation between serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) and BMD in male subjects with SCI. Methods. Dual-energy X-ray absorptiometry (DXA) was used to assess BMD in femoral neck, trochanter, intertrochanteric zone, and lumbar vertebras. Blood samples were taken to measure serums lipids and bone biomarkers including osteocalcin, cross-linked type I collagen (CTX), and bone alkaline phosphatase (BALP). Partial correlation analysis was used to evaluate the relationships between mentioned measurements after adjustment for weight and age. Results. We found a positive correlation between HDL and femoral neck BMD (P: 0.004, r = 0.33). HDL was negatively correlated with osteocalcin (P: 0.017, r = −0.31) which was not in consistency with its relationship with BMD. TC and LDL were not related to CTX, BALP and BMD. Conclusion. This study does not support a strong association between serum lipids and BMD in subjects with SCI. Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation.

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Section: Discussioncontrasting

confidence: 70%

Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?

Sabour

Javidan

Latifi

et al. 2014

Journal of Osteoporosis

View full text Add to dashboard Cite

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“…[14] Few studies have also shown no relationship between TC and LDL-c with BMD at any site. [5781619] Several of these studies are weakened by either small sample size,[511] selection bias,[19] or inclusion of subjects with comorbidities, as well as and consumption of medication known to affect BMD. [5]…”

Section: Discussionmentioning

confidence: 99%

“…Studies evaluating the relationship between lipid parameters and bone mineral density (BMD) in healthy adults and those with metabolic syndrome have revealed inconsistent results. [34567891011121314151617181920212223242526] While most of the studies have been performed in women, there are a few studies in men[345678] and adolescents. [5] Since Indians have differences in lipid profiles [higher prevalence of high triglycerides (TGs) and low high density lipoprotein cholesterol] compared with other populations,[27] we assessed the relationship between various lipid parameters with BMD at different sites in previously conducted cross-sectional population in healthy Indian volunteers.…”

Section: Introductionmentioning

confidence: 99%

Relationship of lipid parameters with bone mineral density in Indian population

Garg

Marwaha

Tandon

et al. 2014

Indian J Endocr Metab

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Introduction:Cardiovascular disease and osteoporosis share common risk factors including dyslipidemia. There are conflicting reports of differential relation of various lipid parameters on bone mineral density (BMD). Hence, we studied the correlation between lipid parameters and BMD in healthy adult.Materials and Methods:A total of 2347 participants (male 39.4%; female 60.6%) included in this cross-sectional study were divided according to sex and age. Fasting blood samples were drawn for biochemical parameters. BMD at lumbar spine, femur, and forearm were measured by dual energy X-ray absorptiometry (DXA).Results:In males, BMD at femur and lumbar spine decreased significantly with increasing quartiles of total cholesterol (TC) (P < 0.0001, and 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.001, and 0.01). In premenopausal women, BMD at femoral neck (P = 0.001) and lumbar spine (P = 0.029) showed declining trend with LDL-c (P = 0.007). In postmenopausal women, only BMD at total femur decreased significantly with TC (P = 0.024) and LDL-c (P = 0.036). All above findings were confirmed in correlation studies. In multiple regression analysis after adjusting for age, body mass index, ionized calcium, alkaline phosphatase, 25 hydroxy vitamin D, and parathyroid hormone levels correlation of BMD with TC and LDL-c persisted. TC, LDL-c was higher in subjects with low bone density compared those with normal bone density in both sexes.Conclusions:TC and LDL-c had weak but significant negative correlation with BMD at femur and lumbar spine.

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“…The results are debatable because both positive and negative relationships have been found. Besides, few studies indicated no significant association between lipid levels and BMD …”

Section: Introductionmentioning

confidence: 99%

“…Besides, few studies indicated no significant association between lipid levels and BMD. 9,10 The potential explanations for these associations may be the coexistence factors of osteoporosis and age-independent atherosclerotic calcification including oxidized lipids, leptin and osteoprotegerin. 11 Several receptors reside on both osteocytes and endovascular lining cells may play important roles in both systems.…”

Section: Introductionmentioning

confidence: 99%