Serum Lipid Profile in Preterm and Term Appropriate for Gestational Age Indian Newborns: A Hospital Based Comparative Study

Shenoy, Janardhana; Reddy, Venkat D; Baliga, Kiran

doi:10.4172/2167-0897.1000156

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…In our study the mean TC was 73.31mg%, like those reported by other studies from India (5,14) (8), higher TGL levels were reported in Iranian newborns (9,10). The high TGL in these studies has been partly attributed to a high prevalence of vitamin D deficiency (9,10).…”

Section: Discussionsupporting

confidence: 85%

Umbilical cord serum lipid profile of healthy neonates- A single center study from rural Tamil Nadu, India

A.G.¹,

Meenakshi²,

Porchelvan³

et al. 2022

Biomedicine

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Introduction and Aim: Umbilical cord lipid profile of neonates might help facilitate the assessment of risk of developing atherosclerotic disorders later in life. This study prospectively measures the cord blood lipid profile of healthy newborn at birth in medical college hospital in rural Tamil Nadu. Material sand Methods: Consecutive full-term newborns (n=105) were enrolled for this study. Umbilical cord blood sample was collected from placental end of the cord immediately after delivery of placenta of each baby and sent to the lab for lipid profile estimation. Results: In the newborns born to non-diabetic mothers, the mean cord blood total serum cholesterol (TC) was 73.31mg %, triglyceride (TGL) was 51.50mg %, high-density lipoproteins (HDL) 24.62 mg % and low-density lipoproteins (LDL) 51.73 mg %. Amongst newborns born to diabetic mothers, the mean TC was 113 mg % (P = 0.001), TGL 98.08mg% (P = 0.045) HDL 28.75 mg% (P = 0.130) LDL 73.48mg% (P = 0.007). Umbilical cord blood lipid profile did not show any significant sex-dependent difference. There was no statistical difference in lipid values between appropriate for gestational age (AGA)and small for gestational age (SGA). Birth weight had a negative correlation to cord blood serum TC and TGL values and showed no correlation to HDL and LDL values. Other parameters including head circumference, length of newborn at birth also showed no correlation to lipid profile. Total cholesterol, TGL and LDL were significantly elevated in newborns born to diabetic mothers. There was no statistical difference in cord blood lipid profile of babies born to mothers who were hypertensive. Conclusion: Infants born to diabetic mothers tend to have significantly elevated lipid values at birth and must be followed regularly later in life to diagnose and treat dyslipidemia and diabetes, to prevent onset of premature atherosclerotic coronary artery disease in this population.

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Section: Discussionsupporting

confidence: 85%

Umbilical cord serum lipid profile of healthy neonates- A single center study from rural Tamil Nadu, India

A.G.¹,

Meenakshi²,

Porchelvan³

et al. 2022

Biomedicine

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“…"Our study agrees with the finding of Ajay Kumar et al, who reported that Term AGA and Preterm AGA had higher TC levels than Term SGA and Preterm SGA, but the difference was not statistically significant. On the other hand, Term SGA and Preterm SGA had higher TG levels than Term AGA and Preterm AGA, and the difference was statistically significant (p=<0.05)" [23].…”

Section: Resultsmentioning

confidence: 89%

Determining the Correlation between Cord Blood Lipid Profile and Birth Weight among Term Babies

Rathod,

Jadhao,

Shah

et al. 2023

AJPR

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Aims: This study aimed to examine the association between cord blood lipid levels and neonatal birth weight. Study Design: Hospital based prospective cross-sectional study. Place and Duration of Study: Study was conducted in Government medical College Nagpur, a tertiary care hospital that provides maternal and child health services between June 2011 to March 2013 Methodology: We enrolled 200 healthy pregnant women who attended antenatal clinics in our hospital. We collected 5 mL of cord blood from the umbilical vein and measured the serum levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol using spectrophotometric methods. We calculated LDL cholesterol using Friedewald’s formula, and we measured anthropometric parameters using standard methods. Results: Neonates with SGA had significantly lower birth weight (2.24 ± 0.3 vs 2.83 ± 0.4; P < 0.01), head circumference (31.5 ± 1.5 vs 33.4 ± 1.8; P < 0.04), recumbent length (51.2 ± 0.3 vs 53.6 ± 0.2; P < 0.04), and Ponderal Index (2.24 ± 0.5 vs 2.35 ± 0.2; P < 0.03) than AGA babies. The cord blood lipid profile levels were also significantly lower (P < 0.001) in AGA than SGA babies. There was a positive correlation between birth weight and total cholesterol (r = 0.31; P < 0.001) and triglycerides (r = 0.46; P < 0.001), and a small positive correlation between birth weight and HDL cholesterol (r = 0.157; P = 0.013). Conclusion: SGA babies had significantly higher cord blood lipid profile levels than AGA babies. The lipid profile of umbilical cord blood is related to the fetal nutritional status and growth and development. This may have implications for the prevention and management of low birth weight and its associated complications

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“…Therefore, those who have experienced intrauterine growth restriction need to use endogenous reserves, activating lipid metabolism to generate energy and promote gluconeogenesis. The longterm consequences of these metabolic adaptations will lead to an increase in the prevalence of cardiovascular diseases, hypertension and DM2 in this group 25 …”

mentioning

confidence: 99%

Growth and biochemical markers of preterm newborns up to six months of corrected age

Barreto

Balbo

Rover

et al. 2018

J. Hum. Growth Dev.

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Growth and biochemical markers of preterm newborns up to six months of corrected age AbstractIntroduction: Due to advances in recent decades in maternalfoetal and neonatal medicine, a greater survival of preterm infants with progressively smaller birth weight and gestational age is observed, increasing the risk of future morbidities on those infants. Among these morbidities, alterations in growth and metabolism are found.Objective: To analyze the evolution of the growth and the metabolic profile of preterm infants' cohort from birth at six months of corrected age (CA). Methods:A descriptive and prospective study with a sample of 107 mothers and 115 preterm infants at birth and 72 preterm infants and 68 mothers at the end of followup. Growth (body weight, height, cephalic perimeter) was evaluated at six time points. Plasma concentrations of cholesterol, triglycerides, glucose and insulin of premature infants were assessed during three periods, from birth to 6 months of CA. Comparative analysis of the initial sample and the sample that finished the follow-up was used in chi-square family tests. To Evaluate the growth over the 6-month period by using repeated measurements.Results: Sociodemographic variables and maternal biochemical profile without statistical differences in the comparison of the mothers of the initial sample with those who completed the follow-up. Linear growth of preterm infants at six months of CA, however without recovery of growth. Plasma concentrations of triglycerides (birth = 48.1, 6 months = 151.1) and cholesterol (birth = 82.7, 6 months = 139.9) increased during the evaluations. Glycaemia remained stable (birth 80.4, 6 months = 83.3) and insulin decreased from 11.0 to 4.2. Conclusion:Growth of preterm infants, although linear, was lower than expected for age. Lipid profiles presented an ascending curve from birth onward. Therefore, this group is prone to delayed growth and to developing cardiovascular changes throughout life.Keywords: premature infant, growth, lipids, blood glicose, insulin. Corresponding author:clausviera@gmail.com Suggested citation: Barreto GMS, Balbo SL, Rover MS, Toso BRGO, Oliveira HR, Vieira CS. Growth and biochemical markers of preterm newborns up to six months of corrected age.

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Serum Lipid Profile in Preterm and Term Appropriate for Gestational Age Indian Newborns: A Hospital Based Comparative Study

Cited by 5 publications

References 16 publications

Umbilical cord serum lipid profile of healthy neonates- A single center study from rural Tamil Nadu, India

Umbilical cord serum lipid profile of healthy neonates- A single center study from rural Tamil Nadu, India

Determining the Correlation between Cord Blood Lipid Profile and Birth Weight among Term Babies

Growth and biochemical markers of preterm newborns up to six months of corrected age

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