Serum luteinizing hormone level and luteinizing hormone/follicle-stimulating hormone ratio but not serum anti-Müllerian hormone level is related to ovarian volume in Korean women with polycystic ovary syndrome

Abstract

ObjectiveThe aim of the present study was to investigate the relationship between ovarian follicle count and volume on ultrasonography and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin in women with the polycystic ovary syndrome (PCOS).MethodsA total of 118 Korean women aged 18-35 years who were newly diagnosed with PCOS at a university hospital were included in this study. Serum LH, FSH, and AMH levels were measured in the early follicular phase, and the total antral follicle count (TFC) and the total ovarian volume (TOV) were assessed by ultrasonography. The correlations between serum hormonal parameters and ultrasonography characteristics in women with PCOS were evaluated using Pearson's correlation coefficients and a linear regression analysis.ResultsSerum AMH levels were significantly correlated with serum LH levels and LH/FSH ratios, and TFC and TOV were significantly correlated with each other on ultrasonography. Serum AMH and LH levels and the LH/FSH ratio were significantly correlated with TFC. Statistically significant correlations between TOV and the LH level (r=0.208, p=0.024) and the LH/FSH ratio (r=0.237, p=0.010) were observed. However, the serum AMH level was not significantly correlated with the ovarian volume, and this result did not change after adjusting for age and body mass index.ConclusionSerum AMH is not related to the ovarian volume in women with PCOS. My results suggest that serum LH level and the LH/FSH ratio may be more useful than the serum AMH level for representing the status of the ovarian volume in women with PCOS.

Association between serum gonadotropin level and insulin resistance-related parameters in Korean women with polycystic ovary syndrome

“…In the current study, we categorized all participants into three groups according to the LH/FSH ratio: group 1 (LH/FSH ratio <1.0), group 2 (1.0≤ LH/FSH ratio <2.0), and group 3 (LH/FSH ratio ≥2.0). In this study, participants with higher LH/FSH ratios showed higher total antral follicle counts and larger total ovarian volume, and these findings are in agreement with those of previous studies [1516222324]. …”

Age related endocrine patterns observed in polycystic ovary syndrome patients vs. ovulatory controls: descriptive data from a university based infertility center

“…Accordingly, several threshold AMH values for PCOS (based on measurements among varied age and ethnic groups) have been proposed. Of note, serum AMH has been considered as a substitute for antral follicle count as articulated by the Rotterdam diagnostic criteria for PCOS (4)(5)(6)(7)(8)(9)(10)(11)(12) although this has not been widely used perhaps due to the lack of a universally standardized AMH serum assay (13).…”

Endocrine and glycolipid metabolism characteristics of diminished ovarian reserve in Chinese women with polycystic ovary syndrome

“…Both the AMH concentration and the LH/ FSH ratio are significantly correlated with the AFC in patients with PCOS. 10 Women with PCOS have high AMH concentrations, whereas those with DOR have low AMH concentrations. Because of the varying sensitivity and specificity, the AMH has yet to be adopted as part of the diagnostic criteria for PCOS.…”